Withdrawals due to adverse events · older adults with primary hypertension
Higher BP target (< 150‐160/95‐105 mmHg) showed no clear difference in withdrawals due to adverse effects compared with lower BP target (< 140/90 mmHg) (low certainty).
1 finding from 1 review
Linear growth (length/height) Unit: cm Time frame: 3 months · children under 5 years of age
1 finding from 1 review
Mean height‐for‐age z‐score · children under 5 years of age
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Stuntingb · children under 5 years of age
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse effect: hypercalciuria As defined by trialists Time frame: 3 months · children under 5 years of age
Vitamin D (higher dose) + micronutrient(s) showed no clear difference in adverse effect: hypercalciuria As defined by trialists Time frame: 3… compared with vitamin D (lower dose) + micronutrient(s) (low certainty).
1 finding from 1 review
Hypercalcaemia · children under 5 years of age
Vitamin D (higher dose) + micronutrient(s) showed no clear difference in adverse effect: hypercalcaemia As defined by trialists Time frame:… compared with vitamin D (lower dose) + micronutrient(s) (moderate certainty).
1 finding from 1 review
Adverse effect: hyperphosphataemiab · children under 5 years of age
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse effect: kidney stonesb · children under 5 years of age
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Mean GI symptom scores (during RT) · Men undergoing RT for prostate cancer
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Acute and late GI toxicity (grade 2+) · Men undergoing RT for prostate cancer
Summary of findings: Higher bladder volume showed no clear difference in acute and late GI toxicity (grade 2+) compared with lower bladder volume (low certainty).
1 finding from 1 review
Diarrhoea (grade 2+) · Men undergoing RT for prostate cancer
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
QoL · Men undergoing RT for prostate cancer
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Oral health-related quality of life · Adolescents (10-19 years)
Higher family income / better socioeconomic status is associated with better OHRQoL in adolescents (narrative synthesis; no pooled estimate or GRADE rating).
1 finding from 1 review
Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomesCommunity/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
Adolescents from families with higher incomes and higher levels of maternal education have better OHRQoL scores [34]. Worse oral health status, older age, female sex and worse socioeconomic status were significantly…
Studies not reported
GRADE not reported
Prostate cancer · Participants in observational studies
The meta-analysis of observational studies reported a OR of 0.99 (95% CI 0.87 to 1.12) for higher versus lower circulating vitamin D concentration.
1 finding from 1 review
Breast cancer · Participants in observational studies
The meta-analysis of observational studies reported a OR of 0.99 (95% CI 0.68 to 1.47) for higher versus lower circulating vitamin D concentration.
1 finding from 1 review
Spine bone mineral density · Females (all ages)
Among females in low-to-moderate-risk-of-bias studies, the reported spine-BMD estimate above 2.35 mg/L water fluoride was MD 0.07 g/cm2 (95% CI 0.11 to 0.24; ungraded).
2 findings from 1 review
Dental caries in children · Children (approx. 4-18 years)
Pooling studies that used BMI as a continuous variable showed no significant association between per-unit BMI and childhood dental caries (OR 1.01, 95% CI 0.99 to 1.03; I2=3.5%); ungraded.
3 findings from 1 review
Dental caries · Healthy children and adolescents in the United Arab Emirates
Higher snacking and soft-drink/sugar consumption were associated with more caries in most studies, though one study found no association with sweet-consumption frequency (narrative synthesis; not GRADE-rated).
1 finding from 1 review
Soft drink consumption (Khadri et al.: 0.31, 95% CI 0.14-0.47) and a high extent of snacking (Hashim et al.: high vs low snack level aRR 1.46, 95% CI 1.26-1.70; snacking >=3x vs once daily aRR 1.25, 1.00-1.57) were…
Studies not reported
GRADE not reported
Mortality (at the end of · adults receiving EN via nasogastric or gastrostomy tube
It is very uncertain whether higher threshold (500 mL per six hours or greater) changes mortality (at the end of compared with lower threshold (less than 500 mL per six hours) at time of aspiration (very low certainty).
1 finding from 1 review
Pneumonia · adults receiving EN via nasogastric or gastrostomy tube
It is very uncertain whether higher threshold (500 mL per six hours or greater) changes pneumonia (until discontinued or up to 28 days) compared with lower threshold (less than 500 mL per six hours) at time of aspiration (very low certainty).
1 finding from 1 review