Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

449 questions · 486 findings · 74 reviews

No studies found 34 · 7%GRADE not reported 73 · 15%Very low 127 · 26.1%Low 158 · 32.5%Moderate 69 · 14.2%High 25 · 5.1%

Early warning systems (EWS) and rapid response systems (RRS) vs usual care

Hospital mortality – non‐randomised studies ( · adult on acute hospital wards at risk of clinical deterioration
2 findings from 1 review

Early warning systems (EWS) and rapid response systems (RRS) vs usual care

Length of hospital stay · adult on acute hospital wards at risk of clinical deterioration

The review found no eligible studies for this question.

2 findings from 1 review

Early warning systems (EWS) and rapid response systems (RRS) vs usual care

Adverse events (unexpected cardiac or respiratory arrest) – non‐randomised studies ( · adult on acute hospital wards at risk of clinical deterioration
2 findings from 1 review

Early warning systems (EWS) and rapid response systems (RRS) vs usual care

Composite outcome – randomised trials Composite outcome of incidence (events divided by number of eligible participants admitted to the hospital during the study period) of cardiac arrests without a pre‐existing NFR order, unplanned ICU admissions... · adult on acute hospital wards at risk of clinical deterioration
1 finding from 1 review

Early warning systems (EWS) and rapid response systems (RRS) vs usual care

Composite outcome – non‐randomised studies Composite endpoint of cardiopulmonary arrest, unplanned ICU admission or death per 1000 admitted patients ( · adult on acute hospital wards at risk of clinical deterioration
1 finding from 1 review

Early warning systems (EWS) and rapid response systems (RRS) vs usual care

Unplanned ICU admission – non‐randomised trial ( · adult on acute hospital wards at risk of clinical deterioration
2 findings from 1 review

Early warning systems (EWS) and rapid response systems (RRS) vs usual care

ICU readmission – non‐randomised studies · adult on acute hospital wards at risk of clinical deterioration

The review found no eligible studies for this question.

2 findings from 1 review

Early extraction of a compromised mandibular first permanent molar vs Contralateral non-extraction side (same patient)

Development and eruption of the third molar · Children aged 5 to 15 years with a compromised first permanent molar

Development and eruption of the third molar appeared accelerated after early first permanent molar extraction in two studies (e.g., eruption OR 2.86, 95% CI 1.37 to 5.96); ungraded.

1 finding from 1 review

Early enteral nutrition with supplemental parenteral nutrition (SPN) vs delayed enteral nutrition with SPN

Mortality (timing of outcome measurement unclear) · critically ill adult patients

It is very uncertain whether early enteral nutrition with supplemental parenteral nutrition (SPN) changes mortality (timing of outcome measurement unclear) compared with delayed enteral nutrition with SPN (very low certainty).

1 finding from 1 review

Early enteral nutrition with supplemental parenteral nutrition (SPN) vs delayed enteral nutrition with SPN

Feed intolerance or gastrointestinal complications (as defined by the authors) · critically ill adult patients

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Early developmental intervention programmes vs standard follow‐up

Cognitive outcome · preterm infants
3 findings from 1 review

Summary of findings table ‐ Early developmental intervention programmes vs standard follow‐up

Motor outcome at school age (Griffiths Locomotor, MABC) · preterm infants
2 findings from 1 review