Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

27 questions · 27 findings · 10 reviews

No studies found 6 · 22.2%GRADE not reported 4 · 14.8%Very low 10 · 37%Low 4 · 14.8%Moderate 2 · 7.4%High 1 · 3.7%

Antibiotics vs placebo

Serious adverse events WMD of · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…

Antibiotics showed no clear difference in serious adverse events WMD of compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo or usual care

Serious adverse events Duration 3 days to 3 weeks · acute asthma exacerbation

Antibiotics showed no clear difference in serious adverse events Duration 3 days to 3 weeks compared with placebo or usual care (low certainty).

1 finding from 1 review

Antibiotics vs other antibiotics

Non‐serious adverse events · farmworkers

It is very uncertain whether summary of findings table ‐ Antibiotics changes non‐serious adverse events compared with other antibiotics (very low certainty).

1 finding from 1 review

Antibiotics vs other antibiotics

Adverse events considered non‐serious (penicillin versus cefotaxime) · people with leptospirosis

It is very uncertain whether summary of findings table ‐ Antibiotics changes adverse events considered non‐serious (penicillin versus cefotaxime) compared with other antibiotics (very low certainty).

1 finding from 1 review

Antibiotics vs other antibiotics

Adverse events considered non‐serious (penicillin versus doxycycline) · people with leptospirosis

It is very uncertain whether summary of findings table ‐ Antibiotics changes adverse events considered non‐serious (penicillin versus doxycycline) compared with other antibiotics (very low certainty).

1 finding from 1 review

Antibiotics vs other antibiotics

Non‐serious adverse events Maximum · people with leptospirosis

It is very uncertain whether summary of findings table ‐ Antibiotics changes adverse events considered non‐serious (penicillin versus… compared with other antibiotics (very low certainty).

1 finding from 1 review