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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
361 questions in 74 reviews · Pain, Palliative and Supportive Care
current versionsNo studies 361 · 100%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Acupuncture vs other active therapy Participants experiencing any serious adverse event · adults with neuropathic pain Acupuncture for neuropathic pain in adults (2017) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture vs other active therapy Quality of life · adults with neuropathic pain Acupuncture for neuropathic pain in adults (2017) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture combined with other active therapy vs other active therapy Participant‐reported pain relief substantial (at least 50% pain relief over baseline) · adults with neuropathic pain Acupuncture for neuropathic pain in adults (2017) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture combined with other active therapy vs other active therapy Participants experiencing any serious adverse event · adults with neuropathic pain Acupuncture for neuropathic pain in adults (2017) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture vs sham acupuncture Participant‐reported pain relief substantial (at least 50% pain relief over baseline) · adults with neuropathic pain Acupuncture for neuropathic pain in adults (2017) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture vs sham acupuncture Participants experiencing any serious adverse event · adults with neuropathic pain Acupuncture for neuropathic pain in adults (2017) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture vs treatment Participant‐reported pain intensity · adults with neuropathic pain Acupuncture for neuropathic pain in adults (2017) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture vs treatment Participant‐reported pain relief · adults with neuropathic pain Acupuncture for neuropathic pain in adults (2017) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture vs treatment Participants experiencing any serious adverse event · adults with neuropathic pain Acupuncture for neuropathic pain in adults (2017) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture vs treatment Quality of life · adults with neuropathic pain Acupuncture for neuropathic pain in adults (2017) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture vs other active therapy Participant‐reported pain intensity · adults with neuropathic pain Acupuncture for neuropathic pain in adults (2017) · Cochrane | no estimate extracted | NR | No studies |
Methadone vs placebo CI: confidence interval. · adults with chronic neuropathic pain Methadone for neuropathic pain in adults (2017) · Cochrane | no estimate extracted | NR | No studies |
Amitriptyline vs gabapentin Participant‐reported pain relief of 30% or greater · children and adolescents (birth to 17 years) with chronic non‐cancer pain Antidepressants for chronic non‐cancer pain in children and adolescents (2017) · Cochrane | no estimate extracted | NR | No studies |
Citalopram vs placebo Participant‐reported pain relief of 30% or greater · children and adolescents with functional abdominal pain Antidepressants for chronic non‐cancer pain in children and adolescents (2017) · Cochrane | no estimate extracted | NR | No studies |
Citalopram vs placebo Participant‐reported pain relief of 50% or greater · children and adolescents with functional abdominal pain Antidepressants for chronic non‐cancer pain in children and adolescents (2017) · Cochrane | no estimate extracted | NR | No studies |
Citalopram vs placebo Patient Global Impression of Change: much improved or very much improved · children and adolescents with functional abdominal pain Antidepressants for chronic non‐cancer pain in children and adolescents (2017) · Cochrane | no estimate extracted | NR | No studies |
Amitriptyline vs gabapentin Participant‐reported pain relief of 50% or greater · children and adolescents (birth to 17 years) with chronic non‐cancer pain Antidepressants for chronic non‐cancer pain in children and adolescents (2017) · Cochrane | no estimate extracted | NR | No studies |
Amitriptyline vs gabapentin Patient Global Impression of Change: much improved or very much improved · children and adolescents (birth to 17 years) with chronic non‐cancer pain Antidepressants for chronic non‐cancer pain in children and adolescents (2017) · Cochrane | no estimate extracted | NR | No studies |
Amitriptyline vs placebo Participant‐reported pain relief of 30% or greater · children and adolescents (birth to 17 years) with chronic non‐cancer pain Antidepressants for chronic non‐cancer pain in children and adolescents (2017) · Cochrane | no estimate extracted | NR | No studies |
Amitriptyline vs placebo Participant‐reported pain relief of 50% or greater · children and adolescents (birth to 17 years) with chronic non‐cancer pain Antidepressants for chronic non‐cancer pain in children and adolescents (2017) · Cochrane | no estimate extracted | NR | No studies |
Amitriptyline vs placebo Patient Global Impression of Change: much improved or very much improved · children and adolescents (birth to 17 years) with chronic non‐cancer pain Antidepressants for chronic non‐cancer pain in children and adolescents (2017) · Cochrane | no estimate extracted | NR | No studies |
Gabapentin vs amitriptyline Participant‐reported pain relief of 30% or greater · children and adolescents (birth to 17 years of age) with chronic non‐cancer pain Antiepileptic drugs for chronic non‐cancer pain in children and adolescents (2017) · Cochrane | no estimate extracted | NR | No studies |
Gabapentin vs amitriptyline Participant‐reported pain relief of 50% or greater · children and adolescents (birth to 17 years of age) with chronic non‐cancer pain Antiepileptic drugs for chronic non‐cancer pain in children and adolescents (2017) · Cochrane | no estimate extracted | NR | No studies |
Gabapentin vs amitriptyline Patient Global Impression of Change: much improved or very much improved · children and adolescents (birth to 17 years of age) with chronic non‐cancer pain Antiepileptic drugs for chronic non‐cancer pain in children and adolescents (2017) · Cochrane | no estimate extracted | NR | No studies |
Celecoxib vs naproxen Any adverse event · children and adolescents with chronic non‐cancer pain Non‐steroidal anti‐inflammatory drugs (NSAIDs) for chronic non‐cancer pain in children and adolescents (2017) · Cochrane | no estimate extracted | NR | No studies |
Rofecoxib vs naproxen Participant‐reported pain relief of 50% or greater · children and adolescents with chronic non‐cancer pain Non‐steroidal anti‐inflammatory drugs (NSAIDs) for chronic non‐cancer pain in children and adolescents (2017) · Cochrane | no estimate extracted | NR | No studies |
Rofecoxib vs naproxen Patient Global Impression of Change much or very much improved · children and adolescents with chronic non‐cancer pain Non‐steroidal anti‐inflammatory drugs (NSAIDs) for chronic non‐cancer pain in children and adolescents (2017) · Cochrane | no estimate extracted | NR | No studies |
Meloxicam vs naproxen Patient Global Impression of Change much or very much improved · children and adolescents with chronic non‐cancer pain Non‐steroidal anti‐inflammatory drugs (NSAIDs) for chronic non‐cancer pain in children and adolescents (2017) · Cochrane | no estimate extracted | NR | No studies |
Celecoxib vs naproxen Participant‐reported pain relief of 50% or greater · children and adolescents with chronic non‐cancer pain Non‐steroidal anti‐inflammatory drugs (NSAIDs) for chronic non‐cancer pain in children and adolescents (2017) · Cochrane | no estimate extracted | NR | No studies |
Celecoxib vs naproxen Patient Global Impression of Change much or very much improved · children and adolescents with chronic non‐cancer pain Non‐steroidal anti‐inflammatory drugs (NSAIDs) for chronic non‐cancer pain in children and adolescents (2017) · Cochrane | no estimate extracted | NR | No studies |
Perioperative infraorbital nerve block vs Infiltration of the incision (peri-incisional infiltration) Duration of postoperative analgesia · Children up to 13 years of age, undergoing cleft lip repair surgery Infraorbital nerve block for postoperative pain following cleft lip repair in children (2016) · Cochrane | This outcome was not reported. | 0 studies | No studies |
Perioperative infraorbital nerve block vs Placebo (sham block) Time to feeding after surgery · Children up to 13 years of age, undergoing cleft lip repair surgery Infraorbital nerve block for postoperative pain following cleft lip repair in children (2016) · Cochrane | This outcome was not reported. | 0 studies | No studies |
Perioperative infraorbital nerve block vs Infiltration of the incision (peri-incisional infiltration) Duration of hospitalisation · Children up to 13 years of age, undergoing cleft lip repair surgery Infraorbital nerve block for postoperative pain following cleft lip repair in children (2016) · Cochrane | The included studies did not report this outcome. | 0 studies | No studies |
Perioperative infraorbital nerve block vs Intravenous analgesia Duration of hospitalisation · Children up to 13 years of age, undergoing cleft lip repair surgery Infraorbital nerve block for postoperative pain following cleft lip repair in children (2016) · Cochrane | None of the included studies reported this outcome. | 0 studies | No studies |
Perioperative infraorbital nerve block vs Intravenous analgesia Heart rate, respiratory rate, and blood pressure · Children up to 13 years of age, undergoing cleft lip repair surgery Infraorbital nerve block for postoperative pain following cleft lip repair in children (2016) · Cochrane | The included studies did not report these outcomes. | 0 studies | No studies |
Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo Serious AE (all levels of baseline pain) · adults with migraine headache ‐ moderate or severe and mild baseline pain Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults (2016) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Adverse events 1 mg morphine vs 2 mg morphinePercentage of participants with any adverse event · patients undergoing knee arthroscopy Single dose intra‐articular morphine for pain control after knee arthroscopy (2016) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Adverse events 1 mg morphine vs 4 mg/5 mg morphinePercentage of participants with any adverse event · patients undergoing knee arthroscopy Single dose intra‐articular morphine for pain control after knee arthroscopy (2016) · Cochrane | no estimate extracted | NR | No studies |
IA morphine vs IM morphine Analgesia durationtime duration from the end of surgery to the time of first analgesic consumption. Scale from: 0 to 100. · patients undergoing knee arthroscopy Single dose intra‐articular morphine for pain control after knee arthroscopy (2016) · Cochrane | no estimate extracted | NR | No studies |
IA morphine vs IM morphine Adverse eventsPercentage of participants with any adverse event · patients undergoing knee arthroscopy Single dose intra‐articular morphine for pain control after knee arthroscopy (2016) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Participants with at least one adverse event · adults with acute postoperative pain Single dose dipyrone (metamizole) for acute postoperative pain in adults (2016) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Cumulative pain score from the end of operation (0 hours) to 72 hours · adults aged ≥ 18 years undergoing elective surgery at any surgical site Liposomal bupivacaine peripheral nerve block for the management of postoperative pain (2016) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Time to first postoperative opioid dose · adults aged ≥ 18 years undergoing elective surgery at any surgical site Liposomal bupivacaine peripheral nerve block for the management of postoperative pain (2016) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Percentage of participants not requiring postoperative opioids over initial 72 hours · adults aged ≥ 18 years undergoing elective surgery at any surgical site Liposomal bupivacaine peripheral nerve block for the management of postoperative pain (2016) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Health economic assessment · adults aged ≥ 18 years undergoing elective surgery at any surgical site Liposomal bupivacaine peripheral nerve block for the management of postoperative pain (2016) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Incidence of adverse events within 30 days of surgery · adults aged ≥ 18 years undergoing elective surgery at any surgical site Liposomal bupivacaine peripheral nerve block for the management of postoperative pain (2016) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Patient‐reported outcomes · adults aged ≥ 18 years undergoing elective surgery at any surgical site Liposomal bupivacaine peripheral nerve block for the management of postoperative pain (2016) · Cochrane | no estimate extracted | NR | No studies |
Oral hydromorphone vs placebo Substantial benefit: ≥ 50% reduction in pain PGIC much improved · adults with chronic neuropathic pain Hydromorphone for neuropathic pain in adults (2016) · Cochrane | no estimate extracted | NR | No studies |
Oral hydromorphone vs placebo Moderate benefit: ≥ 30% reduction in pain PGIC much or very much improved · adults with chronic neuropathic pain Hydromorphone for neuropathic pain in adults (2016) · Cochrane | no estimate extracted | NR | No studies |
Oral hydromorphone vs placebo Serious adverse events · adults with chronic neuropathic pain Hydromorphone for neuropathic pain in adults (2016) · Cochrane | no estimate extracted | NR | No studies |