Gap finder

Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

303 questions in 64 reviews · Hepato-Biliary

current versions
No studies 303 · 100%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Radioembolisation plus sorafenib vs sorafenib monotherapy
Tumour response assessments · people with hepatocellular carcinoma
Yttrium-90 microsphere radioembolisation for unresectable hepatocellular carcinoma (2020) · Cochrane
no estimate extractedNRNo studies
Sclerotherapy vs no intervention
Health‐related quality of life · primary prophylaxis of oesophageal variceal bleeding in children with chronic liver disease or portal vein thrombosis
Sclerotherapy versus sham or no intervention for primary prophylaxis of oesophageal variceal bleeding in… (2020) · Cochrane
no estimate extractedNRNo studies
N‐acetylcysteine vs placebo
Resolution of encephalopathy and coagulopathy ‐ not reported · children with non‐paracetamol (acetaminophen)‐related acute liver failure
N‐acetylcysteine for non‐paracetamol (acetaminophen)‐related acute liver failure (2020) · Cochrane
no estimate extractedNRNo studies
N‐acetylcysteine vs placebo
Quality of life ‐ not reported · children with non‐paracetamol (acetaminophen)‐related acute liver failure
N‐acetylcysteine for non‐paracetamol (acetaminophen)‐related acute liver failure (2020) · Cochrane
no estimate extractedNRNo studies
N‐acetylcysteine vs placebo
Serious adverse events · adult patients with non‐paracetamol (acetaminophen)‐related acute liver failure
N‐acetylcysteine for non‐paracetamol (acetaminophen)‐related acute liver failure (2020) · Cochrane
no estimate extractedNRNo studies
N‐acetylcysteine vs placebo
Resolution of encephalopathy and coagulopathy · adult patients with non‐paracetamol (acetaminophen)‐related acute liver failure
N‐acetylcysteine for non‐paracetamol (acetaminophen)‐related acute liver failure (2020) · Cochrane
no estimate extractedNRNo studies
N‐acetylcysteine vs placebo
Quality of life · adult patients with non‐paracetamol (acetaminophen)‐related acute liver failure
N‐acetylcysteine for non‐paracetamol (acetaminophen)‐related acute liver failure (2020) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Interventions · people with liver cirrhosis and ascites
Treatment for ascites in adults with decompensated liver cirrhosis: a network meta‐analysis (2020) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Serious adverse events (number of people) · people with liver cirrhosis and ascites
Treatment for ascites in adults with decompensated liver cirrhosis: a network meta‐analysis (2020) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Paracentesis plus fluid replacement · people with liver cirrhosis and ascites
Treatment for ascites in adults with decompensated liver cirrhosis: a network meta‐analysis (2020) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Health‐related quality of life · people with liver cirrhosis and ascites
Treatment for ascites in adults with decompensated liver cirrhosis: a network meta‐analysis (2020) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Symptomatic resolution of ascites at maximal · people with liver cirrhosis and ascites
Treatment for ascites in adults with decompensated liver cirrhosis: a network meta‐analysis (2020) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Interventions · people with liver cirrhosis
Antibiotic prophylaxis to prevent spontaneous bacterial peritonitis in people with liver cirrhosis: a… (2020) · Cochrane
no estimate extractedNRNo studies
Intervention NR
No active intervention · people with liver cirrhosis
Antibiotic prophylaxis to prevent spontaneous bacterial peritonitis in people with liver cirrhosis: a… (2020) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Interventions · adults undergoing liver transplantation
Induction immunosuppression in adults undergoing liver transplantation: a network meta‐analysis (2020) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Health‐related quality of life · adults undergoing liver transplantation
Induction immunosuppression in adults undergoing liver transplantation: a network meta‐analysis (2020) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Glucocorticosteroids · adults undergoing liver transplantation
Induction immunosuppression in adults undergoing liver transplantation: a network meta‐analysis (2020) · Cochrane
no estimate extractedNRNo studies
Other plasma expanders vs albumin
Refractory ascites · cirrhotic participants with large ascites treated by paracentesis
Plasma expanders for people with cirrhosis and large ascites treated with abdominal paracentesis (2019) · Cochrane
no estimate extractedNRNo studies
Plasma expanders vs no plasma expanders
Health‐related quality of life · cirrhotic participants with large ascites treated by paracentesis
Plasma expanders for people with cirrhosis and large ascites treated with abdominal paracentesis (2019) · Cochrane
no estimate extractedNRNo studies
Plasma expanders vs no plasma expanders
Refractory ascites · cirrhotic participants with large ascites treated by paracentesis
Plasma expanders for people with cirrhosis and large ascites treated with abdominal paracentesis (2019) · Cochrane
no estimate extractedNRNo studies
Other plasma expanders vs albumin
Health‐related quality of life · cirrhotic participants with large ascites treated by paracentesis
Plasma expanders for people with cirrhosis and large ascites treated with abdominal paracentesis (2019) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Cancer mortality · people with liver metastases
Cryotherapy for liver metastases (2019) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Health‐related quality of life · people with liver metastases
Cryotherapy for liver metastases (2019) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Time to progression of liver metastases · people with liver metastases
Cryotherapy for liver metastases (2019) · Cochrane
no estimate extractedNRNo studies
Phamacotherapies that specifically target ammonia vs placebo or non‐absorbable disaccharides
Hepatic encephalopathy · adults with cirrhosis and hepatic encephalopathy
Pharmacotherapies that specifically target ammonia for the prevention and treatment of hepatic… (2019) · Cochrane
no estimate extractedNRNo studies
Phamacotherapies that specifically target ammonia vs placebo or non‐absorbable disaccharides
Health‐related quality of life · adults with cirrhosis and hepatic encephalopathy
Pharmacotherapies that specifically target ammonia for the prevention and treatment of hepatic… (2019) · Cochrane
no estimate extractedNRNo studies
Band ligation vs no intervention
Outcomes* · adults with oesophageal varices
Band ligation versus no intervention for primary prevention of upper gastrointestinal bleeding in adults… (2019) · Cochrane
no estimate extractedNRNo studies
Band ligation vs no intervention
Non‐serious adverse events · adults with oesophageal varices
Band ligation versus no intervention for primary prevention of upper gastrointestinal bleeding in adults… (2019) · Cochrane
no estimate extractedNRNo studies
Band ligation vs no intervention
Health‐related quality of life · adults with oesophageal varices
Band ligation versus no intervention for primary prevention of upper gastrointestinal bleeding in adults… (2019) · Cochrane
no estimate extractedNRNo studies
Radix Sophorae flavescentis vs no intervention or placebo
Health‐related quality of life · chronic hepatitis B
Radix Sophorae flavescentis versus no intervention or placebo for chronic hepatitis B (2019) · Cochrane
no estimate extractedNRNo studies
Radix Sophorae flavescentis vs no intervention or placebo
Hepatitis B‐related mortality · chronic hepatitis B
Radix Sophorae flavescentis versus no intervention or placebo for chronic hepatitis B (2019) · Cochrane
no estimate extractedNRNo studies
Radix Sophorae flavescentis vs no intervention or placebo
Hepatitis B‐related morbidity · chronic hepatitis B
Radix Sophorae flavescentis versus no intervention or placebo for chronic hepatitis B (2019) · Cochrane
no estimate extractedNRNo studies
Xiao Chai Hu Tang formula vs no intervention
All‐cause mortality · chronic hepatitis B
Xiao Chai Hu Tang, a herbal medicine, for chronic hepatitis B (2019) · Cochrane
no estimate extractedNRNo studies
Xiao Chai Hu Tang formula vs no intervention
Proportion of participants with ≥ 1 serious adverse events · chronic hepatitis B
Xiao Chai Hu Tang, a herbal medicine, for chronic hepatitis B (2019) · Cochrane
no estimate extractedNRNo studies
Xiao Chai Hu Tang formula vs no intervention
Health‐related quality of life · chronic hepatitis B
Xiao Chai Hu Tang, a herbal medicine, for chronic hepatitis B (2019) · Cochrane
no estimate extractedNRNo studies
Xiao Chai Hu Tang formula vs no intervention
Hepatitis B‐related mortality · chronic hepatitis B
Xiao Chai Hu Tang, a herbal medicine, for chronic hepatitis B (2019) · Cochrane
no estimate extractedNRNo studies
Xiao Chai Hu Tang formula vs no intervention
Hepatitis B‐related morbidity · chronic hepatitis B
Xiao Chai Hu Tang, a herbal medicine, for chronic hepatitis B (2019) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Interventions · people with hepatorenal syndrome with decompensated liver cirrhosis
Treatment for hepatorenal syndrome in people with decompensated liver cirrhosis: a network meta‐analysis (2019) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Albumin plus terlipressin · people with hepatorenal syndrome with decompensated liver cirrhosis
Treatment for hepatorenal syndrome in people with decompensated liver cirrhosis: a network meta‐analysis (2019) · Cochrane
no estimate extractedNRNo studies
Radix Sophorae flavescentis vs other drugs or herbs
All‐cause mortality · chronic hepatitis B
Radix Sophorae flavescentis versus other drugs or herbs for chronic hepatitis B (2019) · Cochrane
no estimate extractedNRNo studies
Radix Sophorae flavescentis vs other drugs or herbs
Proportion of participants with ≥ 1 serious adverse events · chronic hepatitis B
Radix Sophorae flavescentis versus other drugs or herbs for chronic hepatitis B (2019) · Cochrane
no estimate extractedNRNo studies
Radix Sophorae flavescentis vs other drugs or herbs
Health‐related quality of life · chronic hepatitis B
Radix Sophorae flavescentis versus other drugs or herbs for chronic hepatitis B (2019) · Cochrane
no estimate extractedNRNo studies
Radix Sophorae flavescentis vs other drugs or herbs
Hepatitis B‐related mortality · chronic hepatitis B
Radix Sophorae flavescentis versus other drugs or herbs for chronic hepatitis B (2019) · Cochrane
no estimate extractedNRNo studies
Radix Sophorae flavescentis vs other drugs or herbs
Hepatitis B‐related morbidity · chronic hepatitis B
Radix Sophorae flavescentis versus other drugs or herbs for chronic hepatitis B (2019) · Cochrane
no estimate extractedNRNo studies
Acupuncture vs no intervention
All‐cause mortality · chronic hepatitis B
Acupuncture for chronic hepatitis B (2019) · Cochrane
no estimate extractedNRNo studies
Acupuncture vs no intervention
Proportion of participants with 1 or more serious adverse events · chronic hepatitis B
Acupuncture for chronic hepatitis B (2019) · Cochrane
no estimate extractedNRNo studies
Acupuncture vs no intervention
Health‐related quality of life · chronic hepatitis B
Acupuncture for chronic hepatitis B (2019) · Cochrane
no estimate extractedNRNo studies
Acupuncture vs no intervention
Hepatitis B‐related mortality · chronic hepatitis B
Acupuncture for chronic hepatitis B (2019) · Cochrane
no estimate extractedNRNo studies
Acupuncture vs no intervention
Hepatitis B‐related morbidity · chronic hepatitis B
Acupuncture for chronic hepatitis B (2019) · Cochrane
no estimate extractedNRNo studies
Acupuncture vs no intervention
Exploratory outcomes: Proportion of participants with detectable HBV DNA (at maximum · chronic hepatitis B
Acupuncture for chronic hepatitis B (2019) · Cochrane
no estimate extractedNRNo studies