Cochrane · systematic review · CD013103
Treatment for hepatorenal syndrome in people with decompensated liver cirrhosis: a network meta‐analysis
Best, LMJ, Freeman, SC, Sutton, AJ, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Hepato-BiliaryAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
16
current version
GRADE rated
14
No studies
2
Included studies
NR
No studies 2 · 12.5%Ungraded 0 · 0%Very low 13 · 81.3%Low 1 · 6.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: people with hepatorenal syndrome with decompensated liver cirrhosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Interventions | no estimate extracted | NR | No studies |
Albumin plus noradrenaline (9 RCTs; 486 participants) | HR 1.33 [0.87, 2] | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Albumin (6 RCTs; 480 participants) | HR 1.06 [0.69, 1.8] | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Albumin plus midodrine plus octreotide (1 RCT; 48 participants) | HR 1.42 [0.52, 3.79] | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Albumin plus midodrine plus octreotide plus pentoxifylline (No RCTs) | HR 0.5 [0.06, 4.07] | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Albumin plus octreotide (1 RCT; 40 participants) | HR 1.46 [0.35, 6.49] | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Albumin plus noradrenaline (1 RCT; 120 participants) | OR 0.82 [0.21, 2.98] | NR | Very low Downgraded: risk of bias, imprecision, indirectness |
Albumin (2 RCTs; 308 participants) | OR 0.8 [0.5, 1.26] | NR | Very low Downgraded: risk of bias, imprecision, indirectness |
Albumin (1 RCT; 46 participants) | Rate ratio 0.91 [0.51, 1.65] | NR | Very low Downgraded: risk of bias, imprecision, indirectness |
Albumin plus noradrenaline (1 RCT; 46 participants) | OR 0.16 [0.01, 1.44] | NR | Very low Downgraded: risk of bias, imprecision, indirectness |
Albumin plus terlipressin | no estimate extracted | NR | No studies |
Albumin plus noradrenaline (4 RCTs; 293 participants) | Rate ratio 0.51 [0.28, 0.87] | NR | Low Downgraded: risk of bias, imprecision |
Albumin (1 RCT; 48 participants) | Rate ratio 0.8 [0.52, 1.22] | NR | Very low Downgraded: risk of bias, imprecision, indirectness |
Albumin plus noradrenaline (1 RCT; 48 participants) | HR 1.09 [0.36, 3.31] | NR | Very low Downgraded: risk of bias, imprecision, indirectness |
Albumin plus noradrenaline (10 RCTs; 518 participants) | HR 0.85 [0.58, 1.28] | NR | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Albumin (4 RCTs; 406 participants) | HR 0.28 [0.14, 0.53] | NR | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |