Cochrane · systematic review · CD004039
Plasma expanders for people with cirrhosis and large ascites treated with abdominal paracentesis
Simonetti, RG, Perricone, G, Nikolova, D, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Hepato-BiliaryAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
13
current version
GRADE rated
9
No studies
4
Included studies
NR
No studies 4 · 30.8%Ungraded 0 · 0%Very low 9 · 69.2%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Plasma expanders versus no plasma expanders for people with cirrhosis and large ascites treated with abdominal paracentesis
Population: cirrhotic participants with large ascites treated by paracentesis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality Plasma expanders vs no plasma expanders | RR 0.52 [0.06, 4.83] | 4 studies · 248 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Serious adverse events Plasma expanders vs no plasma expanders | no estimate extracted | 2 studies · 108 participants | Very low Downgraded: risk of bias, imprecision |
Health‐related quality of life Plasma expanders vs no plasma expanders | no estimate extracted | NR | No studies |
Refractory ascites Plasma expanders vs no plasma expanders | no estimate extracted | NR | No studies |
Other liver‐related complications Plasma expanders vs no plasma expanders | RR 1.61 [0.79, 3.27] | 4 studies · 248 participants | Very low Downgraded: risk of bias, imprecision |
Non‐serious adverse events Plasma expanders vs no plasma expanders | RR 1.04 [0.32, 3.4] | 3 studies · 158 participants | Very low Downgraded: risk of bias, imprecision |
Other plasma expanders versus albumin for people with cirrhosis and large ascites treated with abdominal paracentesis
Population: cirrhotic participants with large ascites treated by paracentesis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality Other plasma expanders vs albumin | RR 1.03 [0.82, 1.3] | 14 studies · 1014 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Serious adverse events Other plasma expanders vs albumin | RR 0.89 [0.1, 8.3] | 2 studies · 118 participants | Very low Downgraded: risk of bias, imprecision |
Health‐related quality of life Other plasma expanders vs albumin | no estimate extracted | NR | No studies |
Refractory ascites Other plasma expanders vs albumin | no estimate extracted | NR | No studies |
Renal impairment Other plasma expanders vs albumin | RR 1.17 [0.71, 1.91] | 17 studies · 1107 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Other liver‐related complications Other plasma expanders vs albumin | RR 1.1 [0.82, 1.48] | 16 studies · 1083 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Non‐serious adverse events Other plasma expanders vs albumin | RR 1.37 [0.66, 2.85] | 14 studies · 977 participants | Very low Downgraded: risk of bias, imprecision |