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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

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Intervention or exposure

Comparison

Outcome

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Review versions

141 questions in 31 reviews · Emergency and Critical Care

current versions

No studies 141 · 100%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Question	Effect	Evidence	Status / GRADE
Sumatriptan vs placebo Risk of high altitude pulmonary oedema ‐ not reported · participants at risk of high altitude illness Interventions for preventing high altitude illness: Part 2. Less commonly‐used drugs (2018) · Cochrane	no estimate extracted	NR	No studies
Sumatriptan vs placebo Risk of high altitude cerebral oedema ‐ not reported · participants at risk of high altitude illness Interventions for preventing high altitude illness: Part 2. Less commonly‐used drugs (2018) · Cochrane	no estimate extracted	NR	No studies
Sumatriptan vs placebo Risk of adverse events ‐ not reported · participants at risk of high altitude illness Interventions for preventing high altitude illness: Part 2. Less commonly‐used drugs (2018) · Cochrane	no estimate extracted	NR	No studies
Magnesium citrate vs placebo Risk of high altitude pulmonary oedema‐ not reported · participants at risk of high altitude illness Interventions for preventing high altitude illness: Part 2. Less commonly‐used drugs (2018) · Cochrane	no estimate extracted	NR	No studies
Magnesium citrate vs placebo Risk of high altitude cerebral oedema‐ not reported · participants at risk of high altitude illness Interventions for preventing high altitude illness: Part 2. Less commonly‐used drugs (2018) · Cochrane	no estimate extracted	NR	No studies
Simple aspiration vs intercostal tube drainage Cost‐effectiveness Not reported · adults with primary spontaneous pneumothorax Simple aspiration versus intercostal tube drainage for primary spontaneous pneumothorax in adults (2017) · Cochrane	no estimate extracted	NR	No studies
Aerosolized prostacyclin vs placebo Improvement in mean pulmonary arterial pressure · people with ARDS Aerosolized prostacyclins for acute respiratory distress syndrome (ARDS) (2017) · Cochrane	no estimate extracted	NR	No studies
Dexamethasone vs placebo Incidence of high altitude pulmonary oedema (HAPE)‐ not reported · people at risk of high altitude illness Interventions for preventing high altitude illness: Part 1. Commonly‐used classes of drugs (2017) · Cochrane	no estimate extracted	NR	No studies
Dexamethasone vs placebo Incidence of high altitude cerebral oedema (HACE) ‐ not reported · people at risk of high altitude illness Interventions for preventing high altitude illness: Part 1. Commonly‐used classes of drugs (2017) · Cochrane	no estimate extracted	NR	No studies
Budesonide vs placebo Incidence of high altitude pulmonary oedema (HAPE)‐ not reported · people at risk of high altitude illness Interventions for preventing high altitude illness: Part 1. Commonly‐used classes of drugs (2017) · Cochrane	no estimate extracted	NR	No studies
Budesonide vs placebo Incidence of high altitude cerebral oedema (HACE)‐ not reported · people at risk of high altitude illness Interventions for preventing high altitude illness: Part 1. Commonly‐used classes of drugs (2017) · Cochrane	no estimate extracted	NR	No studies
Capnography and standard monitoring vs standard monitoring Recovery time · patients undergoing PSA Capnography versus standard monitoring for emergency department procedural sedation and analgesia (2017) · Cochrane	no estimate extracted	NR	No studies
PCT vs non‐PCT (standard care or CRP: primary outcomes) Participants with antimicrobial regimen changed from a broad to a narrower spectrum · adult patients with sepsis, severe sepsis and septic shock Effectiveness and safety of procalcitonin evaluation for reducing mortality in adults with sepsis, severe… (2017) · Cochrane	no estimate extracted	NR	No studies
High‐frequency oscillation vs conventional ventilation Outcomes** · people with Acute Respiratory Distress Syndrome High‐frequency oscillatory ventilation versus conventional ventilation for acute respiratory distress syndrome (2016) · Cochrane	no estimate extracted	NR	No studies
Lateral positioning vs supine immobilization Mortality ‐ not measured · critically ill adult patients Lateral positioning for critically ill adult patients (2016) · Cochrane	no estimate extracted	NR	No studies
Right lateral position vs left lateral position Hypotensione ‐ not reported · critically ill adult patients Lateral positioning for critically ill adult patients (2016) · Cochrane	no estimate extracted	NR	No studies
Right lateral position vs left lateral position Profound hypertensiong ‐ not reported · critically ill adult patients Lateral positioning for critically ill adult patients (2016) · Cochrane	no estimate extracted	NR	No studies
Right lateral position vs left lateral position Low oxygen delivery (DO2)h ‐ not reported · critically ill adult patients Lateral positioning for critically ill adult patients (2016) · Cochrane	no estimate extracted	NR	No studies
Intravenous midazolam vs placebo Incomplete procedures · adults requiring sedation before gastrointestinal endoscopy and bronchoscopy Midazolam for sedation before procedures (2016) · Cochrane	no estimate extracted	NR	No studies
Intravenous midazolam vs placebo Anterograde amnesia (defined by number of participants who recalled the procedure) · adults requiring sedation before gastrointestinal endoscopy and bronchoscopy Midazolam for sedation before procedures (2016) · Cochrane	no estimate extracted	NR	No studies
Intravenous midazolam vs placebo Disinhibition or excitation · adults requiring sedation before gastrointestinal endoscopy and bronchoscopy Midazolam for sedation before procedures (2016) · Cochrane	no estimate extracted	NR	No studies
Intravenous midazolam vs placebo Allergic or anaphylactoid reaction · adults requiring sedation before gastrointestinal endoscopy and bronchoscopy Midazolam for sedation before procedures (2016) · Cochrane	no estimate extracted	NR	No studies
Oral midazolam vs chloral hydrate Anterograde amnesia (defined by number of participants who recalled the procedure) · children requiring sedation before procedures that require motion control, including echocardiography, lumbar… Midazolam for sedation before procedures (2016) · Cochrane	no estimate extracted	NR	No studies
Oral midazolam vs chloral hydrate Disinhibition or excitation · children requiring sedation before procedures that require motion control, including echocardiography, lumbar… Midazolam for sedation before procedures (2016) · Cochrane	no estimate extracted	NR	No studies
Oral midazolam vs chloral hydrate Discomfort · children requiring sedation before procedures that require motion control, including echocardiography, lumbar… Midazolam for sedation before procedures (2016) · Cochrane	no estimate extracted	NR	No studies
Oral midazolam vs chloral hydrate Allergic or anaphylactoid reaction · children requiring sedation before procedures that require motion control, including echocardiography, lumbar… Midazolam for sedation before procedures (2016) · Cochrane	no estimate extracted	NR	No studies
Oral midazolam vs placebo Anterograde amnesia (defined by number of participants who recalled the procedure) · children requiring sedation before micturating cystourethrograms and Kirschner wire removal and adults undergoing… Midazolam for sedation before procedures (2016) · Cochrane	no estimate extracted	NR	No studies
Oral midazolam vs placebo Disinhibition or excitation · children requiring sedation before micturating cystourethrograms and Kirschner wire removal and adults undergoing… Midazolam for sedation before procedures (2016) · Cochrane	no estimate extracted	NR	No studies
Oral midazolam vs placebo Allergic or anaphylactoid reaction · children requiring sedation before micturating cystourethrograms and Kirschner wire removal and adults undergoing… Midazolam for sedation before procedures (2016) · Cochrane	no estimate extracted	NR	No studies
Intranasal midazolam vs placebo Anterograde amnesia (defined by number of participants who recalled the procedure) · Children requiring sedation before voiding cystourethrograms and adults undergoing MRI Midazolam for sedation before procedures (2016) · Cochrane	no estimate extracted	NR	No studies
Intranasal midazolam vs placebo Disinhibition or excitation · Children requiring sedation before voiding cystourethrograms and adults undergoing MRI Midazolam for sedation before procedures (2016) · Cochrane	no estimate extracted	NR	No studies
Intranasal midazolam vs placebo Discomfort/pain · Children requiring sedation before voiding cystourethrograms and adults undergoing MRI Midazolam for sedation before procedures (2016) · Cochrane	no estimate extracted	NR	No studies
Intranasal midazolam vs placebo Allergic or anaphylactoid reaction · Children requiring sedation before voiding cystourethrograms and adults undergoing MRI Midazolam for sedation before procedures (2016) · Cochrane	no estimate extracted	NR	No studies
Intravenous midazolam vs diazepam Disinhibition or excitation · adults and children requiring sedation before gastrointestinal endoscopy and bronchoscopy Midazolam for sedation before procedures (2016) · Cochrane	no estimate extracted	NR	No studies
Intravenous midazolam vs diazepam Allergic or anaphylactoid reaction · adults and children requiring sedation before gastrointestinal endoscopy and bronchoscopy Midazolam for sedation before procedures (2016) · Cochrane	no estimate extracted	NR	No studies
Intervention NR Mortality · critically ill patients Non‐pharmacological interventions for sleep promotion in the intensive care unit (2015) · Cochrane	no estimate extracted	NR	No studies
Intervention NR Economic outcomes · critically ill patients Non‐pharmacological interventions for sleep promotion in the intensive care unit (2015) · Cochrane	no estimate extracted	NR	No studies
Music vs standard care CI: Confidence interval · mechanically ventilated patients Music interventions for mechanically ventilated patients (2014) · Cochrane	no estimate extracted	NR	No studies
Intervention NR Adverse events · mechanically ventilated participants with acute lung injury and acute respiratory distress syndrome Partial liquid ventilation for preventing death and morbidity in adults with acute lung injury and acute… (2013) · Cochrane	no estimate extracted	NR	No studies
Intervention NR Mortality during critical care unit admission Measured using mortality rate in intervention and comparison groups During critical care admission · mechanically ventilated adults with need for aerosol bronchodilator therapy Metered dose inhalers versus nebulizers for aerosol bronchodilator delivery for adult patients receiving… (2013) · Cochrane	no estimate extracted	NR	No studies
Intervention NR Duration of mechanical ventilation Measured as number of days · mechanically ventilated adults with need for aerosol bronchodilator therapy Metered dose inhalers versus nebulizers for aerosol bronchodilator delivery for adult patients receiving… (2013) · Cochrane	no estimate extracted	NR	No studies