Search review questions

Confirmed SARS‐CoV‐2 infection

Severe or critical COVID‐19

Nasal mucosa or skin trauma · adults in the ICU, requiring respiratory support

Fitness to return to work at 12 months · adults with acute respiratory distress syndrome

Late all‐cause mortality ( > 3 months · adults with acute respiratory distress syndrome

Duration of mechanical ventilation · adults with acute respiratory distress syndrome

Ventilator‐free days up to day 28 · adults with acute respiratory distress syndrome

Adverse events Defined as leading to discontinuation of study medication · adults with acute respiratory distress syndrome

Fitness to return to work at 12 months · adults with acute respiratory distress syndrome

Late all‐cause mortality ( > 3 months · adults with acute respiratory distress syndrome

Adverse events Defined as leading to discontinuation of study medication · adults with acute respiratory distress syndrome

Fitness to return to work at 12 months · adults with acute respiratory distress syndrome

Late all‐cause mortality (> 3 months · adults with acute respiratory distress syndrome

Duration of mechanical ventilation · adults with acute respiratory distress syndrome

Fitness to return to work at 12 months · adults with acute respiratory distress syndrome

Adverse events Defined as leading to discontinuation of study medication; or for studies with standard care control, defined by study authors as "serious adverse events" · adults with acute respiratory distress syndrome

Fitness to return to work at 12 months · adults with acute respiratory distress syndrome

Electrolyte disturbances · critically ill adults and children

Hospital length of stay (measured in days) · critically ill adults

Pneumonia (as defined by the authors) ( · critically ill adults

Feed intolerance or gastrointestinal complications (as defined by the authors) · critically ill adults

Neurological function at hospital discharge, measured by cerebral performance category (CPC) · adults and children more than 4 weeks old suffering from OHCA

Neurological function at 30 days, measured by cerebral performance category (CPC) · adults and children more than 4 weeks old suffering from OHCA

Comparison: outcome · participants at risk of high altitude illness

Comparison: outcome · participants at risk of high altitude illness

Comparisons: outcome · participants at risk of high altitude illness

Outcomes and intervention · people suffering from high altitude illness

All‐cause mortality · people suffering from high altitude illness

Complete relief of AMS symptoms · people suffering from high altitude illness

All‐cause mortality · people suffering from high altitude illness

Cognitive impairment · critically ill patients 18 years or older demanding mechanical ventilation within the first 72 hours (Page 2013) or…

The event rate of ICU delirium measured by the CAM‐ICU · critically ill patients 18 years or older treated for respiratory failure or septic or both, cardiogenic or…

Other important secondary outcomes like Any‐cause mortality, ventilator‐associated pneumonia, hospital LOS, amount of sedative agents used, long term functional outcomes and quality of life were not reported in any studies · Mechanically ventilated adults in the intensive care unit

Number of ventilator‐free days up to day 28 · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes…

Adverse events: aspiration (as reported by study authors at end of study · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes…

Adverse events: sepsis (as reported by study authors at end of study · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes…

Adverse events: vomiting (as reported by study authors at end of study · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes…

Number of ICU‐free days up to day 28 · critically ill adults admitted to the ICU for trauma, emergency, or surgical care; population excluded people with…

Number of ICU‐free days up to day 28 · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes…

Time to initiation of fluid resuscitation (Time to initiation starts at the time of admission) · participants of any age admitted to the intensive care or critical care unit for any reason (including, but not…

Quality of life measured at the latest available time point post‐discharge from ICU (preferred measure SF‐36 then EQ‐5D) · participants of any age admitted to the intensive care or critical care unit for any reason (including, but not…

Quantity and quality of sleep as measured through reports of participants or family members or by personnel assessments Data collected at end of study · critically ill adults in the intensive care unit

Adverse events (such as cardiovascular events, respiratory events or illness resulting from immune deficiency) · critically ill adults in the intensive care unit

Anxiety or depression, or both, as measured using validated tools Data collected at end of study · critically ill adults in the intensive care unit

Adverse events (such as cardiovascular events, respiratory events or illness resulting from immune deficiency) · critically ill adults in the intensive care unit

Quantity and quality of sleep as measured by PSG, actigraphy, BIS or EEG Data collected at end of study · critically ill adults in the intensive care unit

Anxiety or depression, or both, as measured using validated tools Data collected at end of study · critically ill adults in the intensive care unit

Adverse events (such as cardiovascular events, respiratory events or illness resulting from immune deficiency) · critically ill adults in the intensive care unit

Risk of adverse events ‐ not reported · participants at risk of high altitude illness

Risk of adverse events ‐ not reported · participants at risk of high altitude illness