Cochrane · systematic review · CD012247
Buffered solutions versus 0.9% saline for resuscitation in critically ill adults and children
Antequera Martín, AM, Barea Mendoza, JA, Muriel, A, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Emergency and Critical CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
7
No studies
1
Included studies
NR
No studies 1 · 12.5%Ungraded 0 · 0%Very low 5 · 62.5%Low 1 · 12.5%Moderate 0 · 0%High 1 · 12.5%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Buffered solutions compared to 0.9% saline for resuscitation in critically ill adults and children
Population: critically ill adults and children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall mortality (in‐hospital death) Buffered solutions vs 0.9% saline | no estimate extracted | 14 studies · 19664 participants | High |
Acute renal Injury (defined as RIFLE or AKIN criteria by study authors) Buffered solutions vs 0.9% saline | no estimate extracted | 9 studies · 18701 participants | Low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Organ system dysfunction (during admission) Buffered solutions vs 0.9% saline | no estimate extracted | 5 studies · 266 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Electrolyte disturbances Buffered solutions vs 0.9% saline | no estimate extracted | NR | No studies |
Plasma potassium, mmol/L (during admission) Buffered solutions vs 0.9% saline | no estimate extracted | 4 studies · 158 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Plasma chloride, mmol/L (during admission) Buffered solutions vs 0.9% saline | no estimate extracted | 7 studies · 351 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Plasma pH (during admission) Buffered solutions vs 0.9% saline | no estimate extracted | 3 studies · 200 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Plasma bicarbonate, mmol/L (during admission) Buffered solutions vs 0.9% saline | no estimate extracted | 6 studies · 344 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, publication bias |