Cochrane · systematic review · CD012454
Propofol for the promotion of sleep in adults in the intensive care unit
Lewis, SR, Schofield‐Robinson, OJ, Alderson, P, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Emergency and Critical CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
5
No studies
7
Included studies
NR
No studies 7 · 58.3%Ungraded 0 · 0%Very low 5 · 41.7%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Propofol for the promotion of sleep in the intensive care unit versus no agent
Population: critically ill adults in the intensive care unit
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Quantity and quality of sleep as measured through reports of participants or family members or by personnel assessments Data collected at end of study Propofol for the promotion of sleep in the intensive care unit vs no agent | no estimate extracted | NR | No studies |
Quantity and quality of sleep as measured by PSG, actigraphy, BIS or EEG Data collected at end of study Propofol for the promotion of sleep in the intensive care unit vs no agent | no estimate extracted | 1 study · 13 participants | Very low Downgraded: risk of bias, imprecision |
Anxiety or depression, or both, as measured using validated tools Data collected at end of study Propofol for the promotion of sleep in the intensive care unit vs no agent | no estimate extracted | NR | No studies |
Adverse events (such as cardiovascular events, respiratory events or illness resulting from immune deficiency) Propofol for the promotion of sleep in the intensive care unit vs no agent | no estimate extracted | NR | No studies |
Propofol for the promotion of sleep in the intensive care unit versus propofol at a different rate or dose
Population: critically ill adults in the intensive care unit
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Quantity and quality of sleep as measured through reports of participants or family members or by personnel assessments Data collected at end of study Propofol for the promotion of sleep in the intensive care unit vs propofol at a different rate or dose | no estimate extracted | 1 study · 30 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Quantity and quality of sleep as measured by PSG, actigraphy, BIS or EEG Data collected at end of study Propofol for the promotion of sleep in the intensive care unit vs propofol at a different rate or dose | no estimate extracted | NR | No studies |
Anxiety or depression, or both, as measured using validated tools Data collected at end of study Propofol for the promotion of sleep in the intensive care unit vs propofol at a different rate or dose | no estimate extracted | NR | No studies |
Adverse events (such as cardiovascular events, respiratory events or illness resulting from immune deficiency) Propofol for the promotion of sleep in the intensive care unit vs propofol at a different rate or dose | no estimate extracted | NR | No studies |
Propofol for the promotion of sleep in the intensive care unit versus another agent specifically administered to promote sleep in the intensive care unit
Population: critically ill adults in the intensive care unit
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Quantity and quality of sleep as measured through reports of participants or family members or by personnel assessments Data collected at end of study Propofol for the promotion of sleep in the intensive care unit vs another agent specifically administered to promote sleep | no estimate extracted | 2 studies · 106 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Quantity and quality of sleep as measured by PSG, actigraphy, BIS or EEG Data collected at end of study Propofol for the promotion of sleep in the intensive care unit vs another agent specifically administered to promote sleep | no estimate extracted | 1 study · 66 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Anxiety or depression, or both, as measured using validated tools Data collected at end of study Propofol for the promotion of sleep in the intensive care unit vs another agent specifically administered to promote sleep | no estimate extracted | 1 study · 40 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Adverse events (such as cardiovascular events, respiratory events or illness resulting from immune deficiency) Propofol for the promotion of sleep in the intensive care unit vs another agent specifically administered to promote sleep | no estimate extracted | NR | No studies |