Cochrane · systematic review · CD013315
Interventions for preventing high altitude illness: Part 3. Miscellaneous and non‐pharmacological interventions
Molano Franco, D, Nieto Estrada, VH, Gonzalez Garay, AG, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Emergency and Critical CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
18
current version
GRADE rated
15
No studies
3
Included studies
NR
No studies 3 · 16.7%Ungraded 0 · 0%Very low 1 · 5.6%Low 14 · 77.8%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings group 1: pre‐acclimatization and other measures based on pressure
Population: participants at risk of high altitude illness
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Comparison: outcome | no estimate extracted | NR | No studies |
Normal versus simulated altitude conditions: risk of AMS | RR 1.18 [0.82, 1.71] | 3 studies · 140 participants | Low Downgraded: risk of bias, imprecision |
Positive end‐expiratory pressure (PEEP) versus nothing: risk of AMS | OR 3.67 [1.38, 9.76] | 1 study · 8 participants | Low Downgraded: risk of bias, imprecision |
Remote ischaemic preconditioning (RIPC) versus placebo: risk of AMS | RR 3 [0.69, 13.12] | 1 study · 40 participants | Low Downgraded: imprecision |
Summary of findings group 2: supplements and vitamins
Population: participants at risk of high altitude illness
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Comparisons: outcome | no estimate extracted | NR | No studies |
Antioxidants versus placebo: risk of AMS | RR 0.58 [0.32, 1.03] | 1 study · 18 participants | Low Downgraded: risk of bias |
Ginkgo biloba versus placebo: risk of AMS | no estimate extracted | 6 studies · 504 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Erythropoietin versus placebo: risk of AMS | RR 0.41 [0.2, 0.84] | 1 study · 39 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Medroxyprogesterone versus placebo: risk of AMS | RR 0.71 [0.48, 1.05] | 2 studies · 32 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Iron supplementation versus placebo: risk of AMS | RR 0.65 [0.38, 1.11] | 2 studies · 65 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Rhodiola crenulata versus placebo: risk of AMS | OR 1 [0.78, 1.29] | 1 study · 125 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Summary of findings group 3: other comparisons
Population: participants at risk of high altitude illness
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Comparison: outcome | no estimate extracted | NR | No studies |
Ginkgo biloba versus acetazolamide: risk of AMS | no estimate extracted | 3 studies · 378 participants | Low Downgraded: risk of bias, inconsistency |
Acetazolamide + ginkgo biloba versus ginkgo biloba: risk of AMS | RR 0.43 [0.26, 0.71] | 1 study · 311 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Acetazolamide + ginkgo biloba versus acetazolamide: risk of AMS | RR 1.27 [0.65, 2.46] | 1 study · 306 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Acetazolamide versus medroxyprogesterone: risk of AMS | RR 1 [0.32, 3.1] | 1 study · 12 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Acetazolamide + medroxyprogesterone versus medroxyprogesterone: risk of AMS | RR 1.33 [0.5, 3.55] | 1 study · 12 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Acetazolamide + medroxyprogesterone versus acetazolamide: risk of AMS | RR 1.33 [0.5, 3.55] | 1 study · 12 participants | Low Downgraded: risk of bias, imprecision, inconsistency |