What do systematic reviews say?

Participant‐reported pain relief of 50% or greater · adults with sickle cell disease in a vaso‐occlusive crisis

Participant‐reported pain relief of 30% or greater · adults with sickle cell disease in a vaso‐occlusive crisis

Participant‐reported pain relief of 30% or greater · adults with sickle cell disease in a vaso‐occlusive crisis

Participant‐reported pain relief of 50% or greater · adults with sickle cell disease in a vaso‐occlusive crisis

Participant‐reported pain relief of 30% or greater · adults with sickle cell disease in a vaso‐occlusive crisis

Participant‐reported pain relief of 30% or greater · children and adolescents with chronic non‐cancer pain

Participant‐reported pain relief of 30% or greater · children (4 to 18 years) with functional abdominal pain disorders

Participant‐reported pain relief of 50% or greater · children (4 to 18 years) with functional abdominal pain disorders

Participant‐reported pain relief of 50% or greater · children and adolescents with chronic non‐cancer pain

Participant‐reported pain relief of 30% or greater · children and adolescents with chronic non‐cancer pain

Participant‐reported pain relief of 50% or greater · children and adolescents with chronic non‐cancer pain

Participant‐reported pain relief of 30% or greater · children and adolescents with chronic non‐cancer pain

Participant‐reported pain relief of 50% or greater · children and adolescents with chronic non‐cancer pain

Participant‐reported pain relief of 50% or greater · children and adolescents with chronic non‐cancer pain

Participant‐reported pain relief of 50% or greater · children and adolescents with chronic non‐cancer pain

Primary outcome ‐ pain on defecation ‐ not reported · women with treating constipation in pregnancy

Primary outcome ‐ pain on defecation ‐ not reported · women with treating constipation in pregnancy

Pain at short term (4 weeks) VAS 10‐cm scale, which was translated to a 0 to 100 scale in which lower scores mean less pain. · Morton's neuroma

Ear pain (otalgia) or discomfort or local irritation · people with CSOM; one study included patients of unknown age; one study included children with CSOM who had not responded to initial…

Ear pain (otalgia) or discomfort or local irritation · schoolchildren with CSOM