What do systematic reviews say?

Short‐term impact (< 12 months) unintended adverse events ‐ not reported · children aged 5 years and under

Adverse events (AEs) (1 or more events) · People with vascular dementia

Adverse events (AEs) (1 or more events) · People with vascular dementia

Adverse events: Vomiting · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes participants with acute…

Number of participant withdrawals due to adverse events ‐ not measured · patients with acute gout

Discontinuation of medication due to adverse events · adults with acute respiratory distress syndrome

Discontinuation of medication due to adverse events · adults with acute respiratory distress syndrome

Proportion of participants with adverse events and severe adverse events · guttate psoriasis

Proportion of participants with adverse events and severe adverse events · guttate psoriasis

Adverse events: aspiration (as reported by study authors at end of study · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes participants with acute…

Proportion of participants with ≥ 1 serious adverse events ‐ not reported · adults with biliary sphincter of Oddi dysfunction

Non‐serious adverse events Timing of outcome assessment: end of treatment · patients with borderline personality disorder

Adverse events (e.g. skin complaints) other than musculoskeletal injuries · healthy adults participating in recreational running

Adverse events (e.g. skin complaints) other than musculoskeletal injuries · healthy adults participating in recreational running

Adverse events (e.g. skin complaints) other than musculoskeletal injuries · military personnel

Adverse events (e.g. skin complaints) other than musculoskeletal injuries · healthy adults participating in recreational running

Adverse events potentially related to Wolbachia‐carrying Aedes deployments · children and adults at risk of dengue infection

Number of women with adverse events (vaginal bleeding, voiding difficulty) · pelvic organ prolapse in women

Number of participants with adverse events leading to study discontinuation · Lennox‐Gastaut syndrome, any age

Severe adverse events or withdrawals (due to adverse events) ‐ not reported · People with hip or knee osteoarthritis