Cochrane · systematic review · CD010284
Traditional Chinese herbal medicine for vascular dementia
Chan, ESY, Bautista, DT, Zhu, Y, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Dementia and Cognitive ImprovementAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
70
current version
GRADE rated
29
No studies
41
Included studies
NR
No studies 41 · 58.6%Ungraded 0 · 0%Very low 6 · 8.6%Low 13 · 18.6%Moderate 10 · 14.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
FuFangDanShen compared to 'no treatment'
Population: people with vascular dementia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cognition‐MMSE FuFangDanShen vs 'no treatment' | no estimate extracted | 2 studies · 95 participants | Low |
Cognition‐HDS ‐ not measured FuFangDanShen vs 'no treatment' | no estimate extracted | NR | No studies |
Cognition‐ADAS‐Cog FuFangDanShen vs 'no treatment' | no estimate extracted | 3 studies · 321 participants | Moderate |
Global performance (improved) ‐ not measured FuFangDanShen vs 'no treatment' | no estimate extracted | NR | No studies |
Adverse events (AEs) (1 or more) FuFangDanShen vs 'no treatment' | RD 0.02 | 3 studies · 322 participants | Low Downgraded: inconsistency |
Activities of Daily Living (ADL) FuFangDanShen vs 'no treatment' | no estimate extracted | 2 studies · 95 participants | Moderate |
Behaviour ‐ not measured FuFangDanShen vs 'no treatment' | no estimate extracted | NR | No studies |
FuFangHaiShe compared to 'no treatment'
Population: People with vascular dementia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cognition‐MMSE FuFangHaiShe vs 'no treatment' | no estimate extracted | 2 studies · 110 participants | Low Downgraded: risk of bias |
Cognition‐HDS ‐ not measured FuFangHaiShe vs 'no treatment' | no estimate extracted | NR | No studies |
Cognition‐ADAS‐Cog ‐ not measured FuFangHaiShe vs 'no treatment' | no estimate extracted | NR | No studies |
Global performance (improved) ‐ not measured FuFangHaiShe vs 'no treatment' | no estimate extracted | NR | No studies |
Adverse events (AEs) (1 or more) FuFangHaiShe vs 'no treatment' | RD 0 | 2 studies · 110 participants | Low Downgraded: risk of bias |
Activities of Daily Living (ADL) FuFangHaiShe vs 'no treatment' | no estimate extracted | 2 studies · 110 participants | Low Downgraded: risk of bias |
Behaviour ‐ not measured FuFangHaiShe vs 'no treatment' | no estimate extracted | NR | No studies |
NaoXinTong compared to 'no treatment'
Population: People with vascular dementia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cognition‐MMSE NaoXinTong vs 'no treatment' | no estimate extracted | 3 studies · 225 participants | Low Downgraded: risk of bias |
Cognition‐HDS ‐ only measured in one study NaoXinTong vs 'no treatment' | no estimate extracted | NR | No studies |
Cognition‐ADAS‐Cog ‐ not measured NaoXinTong vs 'no treatment' | no estimate extracted | NR | No studies |
Global performance (improved) ‐ only measured in one study NaoXinTong vs 'no treatment' | no estimate extracted | NR | No studies |
Adverse events (AEs) (one or more events) ‐ only measured in one study NaoXinTong vs 'no treatment' | no estimate extracted | NR | No studies |
Activities of Daily Living (ADL) NaoXinTong vs 'no treatment' | no estimate extracted | 2 studies · 166 participants | Moderate Downgraded: risk of bias |
Behaviour ‐ not measured NaoXinTong vs 'no treatment' | no estimate extracted | NR | No studies |
YinDanXingNaoTong compared to 'no treatment'
Population: People with vascular dementia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cognition‐MMSE YinDanXingNaoTong vs 'no treatment' | no estimate extracted | 2 studies · 139 participants | Low |
Cognition‐HDS ‐ only measured in one study YinDanXingNaoTong vs 'no treatment' | no estimate extracted | NR | No studies |
Cognition‐ADAS‐Cog ‐ not measured YinDanXingNaoTong vs 'no treatment' | no estimate extracted | NR | No studies |
Global performance (improved) ‐ not‐ measured YinDanXingNaoTong vs 'no treatment' | no estimate extracted | NR | No studies |
Adverse events (AEs) (1 or more events) YinDanXingNaoTong vs 'no treatment' | RD 0 | 2 studies · 138 participants | Low |
Activities of Daily Living (ADL) YinDanXingNaoTong vs 'no treatment' | no estimate extracted | 2 studies · 139 participants | Moderate |
Behaviour ‐ not measured YinDanXingNaoTong vs 'no treatment' | no estimate extracted | NR | No studies |
FuFangHaiShe compared to Western medicine
Population: People with vascular dementia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cognition‐MMSE FuFangHaiShe vs Western medicine | no estimate extracted | 2 studies · 143 participants | Very low Downgraded: risk of bias |
Cognition‐HDS ‐ not measured FuFangHaiShe vs Western medicine | no estimate extracted | NR | No studies |
Cognition‐ADAS‐Cog ‐ only measured in one study FuFangHaiShe vs Western medicine | no estimate extracted | NR | No studies |
Global performance (improved) ‐ not measured FuFangHaiShe vs Western medicine | no estimate extracted | NR | No studies |
AE (1 or more events) FuFangHaiShe vs Western medicine | no estimate extracted | 2 studies · 143 participants | Very low Downgraded: risk of bias |
Activities of Daily Living (ADL) FuFangHaiShe vs Western medicine | no estimate extracted | 2 studies · 143 participants | Very low Downgraded: risk of bias |
Behaviour ‐ not measured FuFangHaiShe vs Western medicine | no estimate extracted | NR | No studies |
NaoMaiTai compared to Western medicine
Population: People with vascular dementia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cognition‐MMSE NaoMaiTai vs Western medicine | no estimate extracted | 4 studies · 289 participants | Moderate Downgraded: risk of bias |
Cognition‐HDS ‐ only measured in one study NaoMaiTai vs Western medicine | no estimate extracted | NR | No studies |
Cognition‐ADAS‐Cog ‐ only measured in one study NaoMaiTai vs Western medicine | no estimate extracted | NR | No studies |
Global performance (improved) ‐ not measured NaoMaiTai vs Western medicine | no estimate extracted | NR | No studies |
Adverse events (AEs) (1 or more events) NaoMaiTai vs Western medicine | RD 0.02 | 4 studies · 277 participants | Very low |
Activities of Daily Living (ADL) ‐ not measured NaoMaiTai vs Western medicine | no estimate extracted | NR | No studies |
Behaviour ‐ not measured NaoMaiTai vs Western medicine | no estimate extracted | NR | No studies |
NaoXinTong compared to Western medicine
Population: People with vascular dementia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cognition‐MMSE NaoXinTong vs Western medicine | no estimate extracted | 6 studies · 461 participants | Moderate Downgraded: risk of bias |
Cognition‐HDS NaoXinTong vs Western medicine | no estimate extracted | 3 studies · 258 participants | Low Downgraded: risk of bias |
Cognition‐ADAS‐Cog ‐ not measured NaoXinTong vs Western medicine | no estimate extracted | NR | No studies |
Global performance (improved) NaoXinTong vs Western medicine | RR 1.43 [1.15, 1.78] | 2 studies · 168 participants | Moderate |
Adverse events (AEs) (1 or more events) NaoXinTong vs Western medicine | no estimate extracted | 7 studies · 515 participants | Moderate Downgraded: risk of bias |
Activities of Daily Living (ADL) NaoXinTong vs Western medicine | no estimate extracted | 3 studies · 227 participants | Moderate Downgraded: risk of bias |
Behaviour ‐ not measured NaoXinTong vs Western medicine | no estimate extracted | NR | No studies |
QingKaiLing compared to Western medicine
Population: People with vascular dementia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cognition‐MMSE ‐ only measured in one study QingKaiLing vs Western medicine | no estimate extracted | NR | No studies |
Cognition‐HDS QingKaiLing vs Western medicine | no estimate extracted | 2 studies · 150 participants | Low Downgraded: risk of bias |
Cognition‐ADAS‐Cog ‐ not measured QingKaiLing vs Western medicine | no estimate extracted | NR | No studies |
Global performance (improved) ‐ not measured QingKaiLing vs Western medicine | no estimate extracted | NR | No studies |
Adverse events (AEs) (one or more events) ‐ only measured in one study QingKaiLing vs Western medicine | no estimate extracted | NR | No studies |
Activities of Daily Living (ADL) ‐ only measured in one study QingKaiLing vs Western medicine | no estimate extracted | NR | No studies |
Behaviour ‐ not measured QingKaiLing vs Western medicine | no estimate extracted | NR | No studies |
ShenFuTang compared to Western medicine
Population: People with vascular dementia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cognition‐MMSE ShenFuTang vs Western medicine | no estimate extracted | 4 studies · 323 participants | Very low Downgraded: risk of bias |
Cognition‐HDS ‐ only measured in one study ShenFuTang vs Western medicine | no estimate extracted | NR | No studies |
Cognition‐ADAS‐Cog ‐ not measured ShenFuTang vs Western medicine | no estimate extracted | NR | No studies |
Global performance (improved) ‐ not measured ShenFuTang vs Western medicine | no estimate extracted | NR | No studies |
Adverse events (AEs) (1 or more events) ShenFuTang vs Western medicine | no estimate extracted | 2 studies · 166 participants | Low Downgraded: risk of bias |
Activities of Daily Living (ADL) ShenFuTang vs Western medicine | no estimate extracted | 2 studies · 189 participants | Very low Downgraded: risk of bias |
Behaviour ‐ not measured ShenFuTang vs Western medicine | no estimate extracted | NR | No studies |
TongXingLuo compared to Western medicine
Population: People with vascular dementia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cognition‐MMSE TongXingLuo vs Western medicine | no estimate extracted | 2 studies · 180 participants | Moderate Downgraded: risk of bias |
Cognition‐HDS ‐ only measured in one study TongXingLuo vs Western medicine | no estimate extracted | NR | No studies |
Cognition‐ADAS‐Cog ‐ not measured TongXingLuo vs Western medicine | no estimate extracted | NR | No studies |
Global performance (improved) TongXingLuo vs Western medicine | RR 1.26 [1, 1.6] | 2 studies · 180 participants | Low Downgraded: risk of bias |
Adverse events (AEs) (1 or more) TongXingLuo vs Western medicine | no estimate extracted | 2 studies · 180 participants | Low Downgraded: risk of bias |
Activities of Daily Living (ADL) ‐ only measured in one study TongXingLuo vs Western medicine | no estimate extracted | NR | No studies |
Behaviour ‐ only measured in one study TongXingLuo vs Western medicine | no estimate extracted | NR | No studies |