Death or requirement for ECMO · respiratory failure in infants born at or near term
Inhaled NO at moderate showed no clear difference in death or requirement for ECMO compared with severe criteria (low certainty).
1 finding from 1 review
Mortality before hospital discharge · respiratory failure in infants born at or near term
Inhaled NO at moderate showed no clear difference in death before hospital discharge compared with severe criteria (moderate certainty).
1 finding from 1 review
Mortality before hospital discharge · respiratory failure in preterm infants
Inhaled NO showed no clear difference in death before discharge ‐ Studies with entry before 3 days based on… compared with control (high certainty).
3 findings from 1 review
RR 1.02 [0.89, 1.18]
10 studies · 1066 participants
High
RR 1.18 [0.81, 1.71]
3 studies · 1075 participants
High
RR 0.9 [0.74, 1.1]
4 studies · 1924 participants
Moderate
Neurodevelopmental disability · respiratory failure in preterm infants
Inhaled NO showed no clear difference in neurodevelopmental disability ‐ Studies with entry after 3 days… compared with control (moderate certainty).
3 findings from 1 review
RR 0.9 [0.74, 1.09]
2 studies · 498 participants
Moderate
RR 0.91 [0.74, 1.13]
3 studies · 1223 participants
High
RR 1.05 [0.78, 1.4]
2 studies · 208 participants
Moderate
Death or bronchopulmonary dysplasia · respiratory failure in preterm infants
Inhaled NO showed no clear difference in death or bronchopulmonary dysplasia at 36 weeks ‐ Studies with entry… compared with control (high certainty).
2 findings from 1 review
Death or bronchopulmonary dysplasia at 36 weeks PMA · respiratory failure in preterm infants
Inhaled NO showed no clear difference in death or bronchopulmonary dysplasia at 36 weeks ‐ Studies with entry… compared with control (high certainty).
1 finding from 1 review
Intraventricular haemorrhage, Papile grade 3/4 · respiratory failure in preterm infants
Inhaled NO showed no clear difference in intraventricular haemorrhage (grade 3 or 4) ‐ Studies with entry… compared with control (high certainty).
2 findings from 1 review
Oxygen requirement at 36 weeks' postmenstrual age · very low birth weight preterm neonates
Early inhaled steroids (< 2 weeks) showed no clear difference in CLD at 36 weeks' PMA oxygen dependency at 36 weeks' PMA compared with placebo (among all randomised) (moderate certainty).
1 finding from 1 review
Death by, or CLD at, 36 weeks' PMA Death or oxygen dependency at 36 weeks' PMA · very low birth weight preterm neonates
Early inhaled steroids (< 2 weeks) probably leads to lower death by, or CLD at, 36 weeks' PMA Death or oxygen dependency at 36… compared with placebo (among all randomised) (moderate certainty).
1 finding from 1 review
CLD at 36 weeks' PMA · very low birth weight preterm neonates
Early inhaled steroid (< 2 weeks) probably leads to lower CLD at 36 weeks' PMA compared with placebo (among survivors) (moderate certainty).
1 finding from 1 review
Intervention not reported
Mortality during hospital stay · neonates requiring intubation and ventilation
The intervention showed no clear difference in mortality during hospital stay (moderate certainty).
1 finding from 1 review
Intervention not reported
Length of NICU stay (days) · neonates requiring intubation and ventilation
1 finding from 1 review
Intervention not reported
PIPP score during drug infusion Range of scale 0‐21 for infants < 28 weeks' PMA and 0‐18 for infants > 36 weeks' PMA. Lower score = less pain (Stevens 1996) · neonates requiring intubation and ventilation
The intervention showed no clear difference in PIPP score during drug infusion Range of scale 0‐21 for infants < 28… (moderate certainty).
1 finding from 1 review
Intervention not reported
Poor neurological outcome by 28 days' postnatal age · neonates requiring intubation and ventilation
The intervention showed no clear difference in poor neurological outcome by 28 days' postnatal age (moderate certainty).
1 finding from 1 review
Intervention not reported
PIPP score during drug infusion Range of scale 0‐21 for infants < 28 weeks' PMA and 0‐18 for infants > 36 weeks' PMA. Lower score = less pain (Stevens 1996) · neonates requiring intubation and ventilation
The intervention showed no clear difference in PIPP score during drug infusion Range of scale 0‐21 for infants < 28… (moderate certainty).
1 finding from 1 review
Intervention not reported
Poor neurological outcome by 28 days' postnatal age · neonates requiring intubation and ventilation
The intervention probably leads to higher poor neurological outcome by 28 days' postnatal age (moderate certainty).
1 finding from 1 review
Death or bronchopulmonary dysplasia at 36 weeks PMA · Neonates with developing BPD
Inhaled steroids showed no clear difference in death or BPD at 36 weeks' postmenstrual age compared with systemic steroids (moderate certainty).
2 findings from 1 review
Diastolic blood pressure > 95th percentile at 7 years · Neonates with developing BPD
Inhaled steroids probably leads to lower diastolic blood pressure > 95th percentile at 7 years compared with systemic steroids (moderate certainty).
1 finding from 1 review
Ever diagnosed as asthmatic by 7 years · Neonates with developing BPD
Inhaled steroids showed no clear difference in ever diagnosed as asthmatic by 7 years compared with systemic steroids (moderate certainty).
1 finding from 1 review
Bronchopulmonary dysplasia/chronic lung disease · Neonates with developing BPD
Inhaled steroids showed no clear difference in BPD at 36 weeks' postmenstrual age compared with systemic steroids (low certainty).
1 finding from 1 review