Cochrane · systematic review · CD002052
Intravenous midazolam infusion for sedation of infants in the neonatal intensive care unit
Ng, E, Taddio, A, Ohlsson, A · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 6 · 100%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: neonates requiring intubation and ventilation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality during hospital stay | RR 0.79 [0.4, 1.56] | 3 studies · 122 participants | Moderate |
Length of NICU stay (days) | 5.4 [0.4, 10.5] | 2 studies · 89 participants | Moderate |
PIPP score during drug infusion Range of scale 0‐21 for infants < 28 weeks' PMA and 0‐18 for infants > 36 weeks' PMA. Lower score = less pain (Stevens 1996) | no estimate extracted | 1 study · 43 participants | Moderate |
Poor neurological outcome by 28 days' postnatal age | RR 1.34 [0.5, 3.56] | 1 study · 43 participants | Moderate |
Comparison
Population: neonates requiring intubation and ventilation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
PIPP score during drug infusion Range of scale 0‐21 for infants < 28 weeks' PMA and 0‐18 for infants > 36 weeks' PMA. Lower score = less pain (Stevens 1996) | MD 1 | 1 study · 46 participants | Moderate |
Poor neurological outcome by 28 days' postnatal age | RR 7.64 [1.02, 57.21] | 1 study · 46 participants | Moderate |