Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,252 questions · 2,353 findings · 210 reviews · Neonatal

No studies found 432 · 18.4%GRADE not reported 99 · 4.2%Very low 609 · 25.9%Low 737 · 31.3%Moderate 385 · 16.4%High 91 · 3.9%

Lower vs higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth

Severe intraventricular haemorrhage · preterm infants

Lower showed no clear difference in severe intraventricular haemorrhage (grade 3 or 4) compared with higher oxygen concentrations titrated to target oxygen saturations… (low certainty).

1 finding from 1 review

Lower vs higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth

Necrotising enterocolitis · preterm infants

Lower showed no clear difference in necrotising enterocolitis compared with higher oxygen concentrations titrated to target oxygen saturations… (low certainty).

1 finding from 1 review

Lower vs higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth

Chronic lung disease · preterm infants

It is very uncertain whether lower changes chronic lung disease (36 weeks' corrected age) compared with higher oxygen concentrations titrated to target oxygen saturations… (very low certainty).

1 finding from 1 review

Systemic administration of beta‐blockers vs placebo or no treatment

Rescue treatment with anti‐VEGF agents · Prevention of retinopathy of prematurity in preterm infants

Systemic administration of beta‐blockers may leads to lower rescue treatment with anti‐VEGF agents compared with placebo or no treatment (low certainty).

1 finding from 1 review

Systemic administration of beta‐blockers vs placebo or no treatment

Treatment with laser photocoagulation or cryotherapy · Prevention of retinopathy of prematurity in preterm infants

Systemic administration of beta‐blockers may leads to lower treatment with laser photocoagulation or cryotherapy compared with placebo or no treatment (low certainty).

1 finding from 1 review

Systemic administration of beta‐blockers vs placebo or no treatment

Progression to stage 2 with plus disease · Prevention of retinopathy of prematurity in preterm infants

Systemic administration of beta‐blockers showed no clear difference in progression to stage 2 with plus disease compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Systemic administration of beta‐blockers vs placebo or no treatment

Progression to stage 3 ROP · Prevention of retinopathy of prematurity in preterm infants

Systemic administration of beta‐blockers probably leads to lower progression to stage 3 ROP compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Systemic administration of beta‐blockers vs placebo or no treatment

Progression to stage 4 or 5 ROP · Prevention of retinopathy of prematurity in preterm infants

Systemic administration of beta‐blockers showed no clear difference in progression to stage 4 or 5 ROP compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Systemic administration of beta‐blockers vs placebo or no treatment

Arterial hypotension and/or bradycardia requiring treatment · Prevention of retinopathy of prematurity in preterm infants

Systemic administration of beta‐blockers may leads to higher arterial hypotension and/or bradycardia requiring treatment compared with placebo or no treatment (low certainty).

1 finding from 1 review

Intervention not reported

Threshold · asymptomatic newborns at the time of pulse oximetry screening

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

95% (less than or less than or equal to) · asymptomatic newborns at the time of pulse oximetry screening
1 finding from 1 review

Oropharyngeal colostrum (OPC) vs No treatment or saline or water

Any late‐onset sepsis ‐ all infants · preterm infants

It is very uncertain whether oropharyngeal colostrum (OPC) changes incidence of late‐onset sepsis compared with control (water, saline, or no intervention) (very low certainty).

1 finding from 1 review

Antibiotics on removal of central venous catheter vs no antibiotics

Late‐onset blood steam infection · newborn infants undergoing removal of central venous catheter

Antibiotics on removal of central venous catheter showed no clear difference in late‐onset blood steam infection compared with no antibiotics (low certainty).

1 finding from 1 review