Findings

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Evidence found and GRADE certainty

3,323 questions · 5,762 findings · 263 reviews · Dental caries

No studies found 321 · 5.6%GRADE not reported 4,450 · 77.2%Very low 455 · 7.9%Low 297 · 5.2%Moderate 200 · 3.5%High 39 · 0.7%

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Baby-led weaning (BLW) vs Traditional complementary feeding (TCF)

Infant weight-length gain (achievement of adequate weight) · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries

Baby-led weaning/BLISS did not significantly influence infant weight-length (adequate weight) gain versus other complementary feeding models (pooled OR 1.36, 95% CI 0.18 to 10.51; ungraded).

1 finding from 1 review

Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive)

Oral hygiene · Children and adolescents (<18 years) living with HIV (CLWH)

Oral hygiene status did not differ significantly between CLWH with and without ART (very low certainty).

1 finding from 1 review

Common genetic variants genome-wide (GWAS; ~3.9 million SNPs with MAF > 5%) vs ECC-unaffected children (per-allele case-control association)

Early childhood caries (ECC) - association at lead SNP rs76823412 (8:134690570; nearest gene(s) ST3GAL1) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)

The common variant rs8091366 near CHST9, KCTD1 showed suggestive (not genome-wide significant) association with ECC (Z = 4.476, p = 7.60e-6); genetic association, ungraded.

2 findings from 1 review

Silver diamine fluoride (SDF) vs placebo

Oral health-related quality of life · Children with dental caries

SDF did not significantly differ from placebo for oral health-related quality of life in children (MD 0.03, 95% CI -0.16 to 0.22; ungraded).

1 finding from 1 review

Food and nonalcoholic beverage marketing (exposure) vs No, less, or less powerful food marketing

Dental caries · Children and adolescents (general population, aged under 20 years)

Evidence on food marketing and dental caries is very uncertain (very low certainty); 1 of 2 studies found an association.

1 finding from 1 review

HVGIC Fuji IX Gold Label vs HVGIC Vitro Molar and Maxxion R

Restoration failure · Children with carious primary teeth

No comparative effect estimate was reported; failure rates were tabulated.

1 finding from 1 review

Oral health education only (verbal, written, or audio-visual education) delivered by non-dental health workers vs control (no intervention/usual care/isotonic exercise)

Caries experience at the surface level (dmfs/defs) · Children (mean age newborn to ~5.2 years) and their parents/carers

Oral-health-education-only interventions did not show a statistically significant effect on surface-level caries (dmfs SMD -0.20, 95% CI -0.43 to 0.03; 2 studies; not GRADE-rated).

1 finding from 1 review

Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy

Angular cheilitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

No eligible studies compared angular cheilitis between different ART regimens.

1 finding from 1 review

Atraumatic restorative treatment with GIC vs Conventional restoration

Restoration failure · Children (3-13 years) with dentine caries in primary teeth, no pulpal involvement

ART with GIC was reported to increase the odds of restoration failure versus conventional restoration (OR 1.60; ungraded).

1 finding from 1 review

Machine-learning algorithms for dental caries detection vs Different machine-learning algorithms for caries prediction

detection of proximal caries · Dental images of human beings

The review reported 85.6% accuracy for proximal caries in Casalegno et al. (Ungraded).

2 findings from 1 review

Caries in first and second primary molars vs Reference (other primary tooth locations / caries-free)

Caries development in permanent teeth · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of age)

Caries in the first and second primary molars is the strongest tooth-specific predictor of caries in permanent teeth (RR 3.4; single study; not GRADE-rated).

1 finding from 1 review

Selective carious tissue removal (selective excavation, SE) vs Non-selective or complete carious tissue removal

Pulp exposure during caries removal · Children with dentine caries in primary and permanent teeth

Partial caries removal was reported to reduce pulp-exposure risk by 77% versus complete caries removal (RR 0.23; ungraded).

1 finding from 1 review

Prior SDF application with a rinsing step vs No prior SDF application (untreated dentin control)

Immediate bond strength (MPa) · Glass-ionomer cement bonded to sound dentin (in vitro)

SDF pretreatment with a rinsing step does not affect glass-ionomer cement bond strength to sound dentin (MD -1.11 MPa, 95% CI -3.47 to 1.25; ungraded).

1 finding from 1 review

Atraumatic restorative treatment plus fluoride varnish vs Silver diamine fluoride plus fluoride varnish

Oral health-related quality of life · Children with dental caries

The direct estimate found no statistically significant difference in oral health-related quality of life between atraumatic restorative treatment plus fluoride varnish and silver diamine fluoride plus fluoride varnish.

2 findings from 1 review

Machine-learning algorithms for dental caries detection vs Different machine-learning algorithms for caries prediction

Occlusal caries detection accuracy · Dental images of human beings

The review reported 66.7% accuracy for the worst class in Moutselos et al. (Ungraded).

4 findings from 1 review
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SDF applied biannually (every 6 months) vs Other non/minimally-invasive treatment (ART or 5% NaF varnish)

Caries arrest · Children (age 1-10 years) with active cavitated dentin caries lesions in primary molars

Biannual SDF application significantly arrested caries (pooled ES 0.39, 95% CI 0.19-0.60; ungraded).

1 finding from 1 review