Tooth discoloration · Patients with carious pulp exposure in permanent teeth undergoing DPC or pulpotomy
More tooth discoloration was observed with MTA than with Biodentine, but odds ratios were implausibly large and not pooled (3 RCTs; ungraded).
1 finding from 1 review
Gingival inflammation-related index · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)
Short-term fluoride mouthwash has uncertain effects on gingival inflammation-related indexes versus blank control (very low certainty).
1 finding from 1 review
MMP-2 presence/activity · Human ex vivo carious dentin
MMP-2 shows no difference between root and coronal carious dentin; the evidence is very uncertain (very low certainty).
1 finding from 1 review
There is no difference in MMP-2 activity in root vs. coronal carious dentin; MMP-2 was present in both coronal and root dentin in all specimens (Toledano et al., 2010). The evidence is very uncertain.
1 study · 10 participants
Very low
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
Resin infiltration was significantly better than CPP-ACP (SMD -0.77, 95% CI -1.31 to -0.23); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Adverse effects on oral health · People who had received fixed appliance orthodontic treatment
The review found no eligible studies for this question.
1 finding from 1 review
Not measured
0 studies
No studies found
Oral health-related quality of life · Adolescents (10-19 years)
Severe periodontal disease is associated with worse OHRQoL in adolescents (narrative synthesis; no pooled estimate or GRADE rating).
1 finding from 1 review
Change in height-for-age z score · Preschool children (<6 years)
The review reported an unadjusted negative association between baseline caries and change in height-for-age z score.
1 finding from 1 review
Harms (orthodontically-induced inflammatory root resorption) · Adolescents and adults with malocclusion undergoing orthodontic treatment with fixed or removable appliances
Light vibrational forces (LVF) showed no clear difference in harms and side effects: orthodontically-induced inflammatory root… compared with conventional orthodontic appliance treatment (placebo or no adjunct) (low certainty).
1 finding from 1 review
Oral health-related quality of life · Indian adults and elderly (general, police, teachers, institutionalised)
Evidence on periodontal disease (CPI) and OHRQoL is inconsistent across studies (very low certainty).
3 findings from 1 review
Periodontal disease (CPI) vs none: studies show inconsistency; two studies showed poor QoL (Nagarajappa 2015, Saxena 2018), one no significant association (Shivakumar 2018); 1345 participants, 3 observational studies;…
3 studies · 1345 participants
Very low
SMD -0.18 [-0.53, 0.18]
4 studies · 3064 participants
Very low
Periodontal disease (CPI) and QoL (continuous, GOHAI): CPI scores negatively correlated with QoL in one study (Rekhi 2016); no significant relation in another (Marya 2020, P>0.05). Not pooled.
2 studies
GRADE not reported
Locoregional recurrence · Adults with oral cavity or oropharyngeal cancer
1 finding from 1 review
Oral health-related quality of life · Indians
Continuous analyses (GOHAI, OHIP-14) of gingivitis and OHRQoL were inconsistent and mostly non-significant; ungraded.
2 findings from 1 review
Gingivitis and QoL (continuous): GOHAI - one study found poorer QoL (Appukuttan 2016, P<0.05), one no significant association (Marya 2020, P=0.08); OHIP-14 - no impact (Sreela 2020, P=0.0762). Not pooled.
3 studies
GRADE not reported
Gingivitis vs no gingivitis: studies show inconsistency; one study showed poor QoL (Shivakumar 2018, OR 1.39, 95% CI 1.09 to 1.67), two studies no significant association (Baiju 2019, Singh 2020); 943 participants, 3…
3 studies · 943 participants
Very low
Plaque · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
Long-term fluoride mouthwash showed mixed plaque-index effects, with very low-certainty evidence.
2 findings from 1 review
PI was similar to blank control [37]; API was slightly reduced compared to blank control and significant at 6 and 9 months [59].
2 studies
Very low
TI was significantly reduced compared to baseline [34]; PI was significantly reduced compared to baseline but similar to blank control [46].
2 studies
Very low
Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in immature permanent teeth
The effect of MTA versus CH in immature teeth is very uncertain (very low certainty).
1 finding from 1 review
Adverse effects on oral health: bleeding on probing (lower arch) · People who had received fixed appliance orthodontic treatment
The review found no eligible studies for this question.
1 finding from 1 review
Survival of retainers (failure/how many failed) · People who had received fixed appliance orthodontic treatment
It is very uncertain whether hawley removable retainer changes survival of retainers (failure, upper and lower arches) compared with clear plastic removable retainer (very low certainty).
1 finding from 1 review
Patient satisfaction: comfort (VAS, upper and lower arches) · People who had received fixed appliance orthodontic treatment
The review found no eligible studies for this question.
1 finding from 1 review
Periapical pathosis · Vital teeth restored with indirect restorations
Periapical pathosis incidence among follow-up >5-10 years was 3.88% (subgroup analysis; not GRADE-rated).
6 findings from 1 review
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Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
Resin infiltration significantly improved remineralization versus control (SMD -0.94, 95% CI -1.46 to -0.43), ranking second of seven therapies by SUCRA (88.7%); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Bacterial collagenolytic protease gene expression · Coronal dentin and enamel caries samples
Genes encoding collagenases and other proteases were overrepresented in dentin caries compared with enamel caries.
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Total mortality · Adults with oropharyngeal cancer
Surgery showed no clear difference in total mortality compared with radiotherapy alone (low certainty).
1 finding from 1 review