Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
CPP-ACFP versus control gave SMD -0.42 (95% CI -0.84 to 0.00); the review classed CPP-ACFP as statistically significant versus control although the reported CI upper limit is at the null (0.00); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Adverse events associated with treatment · Adults with oral cavity or oropharyngeal cancer
1 finding from 1 review
Adverse events: severe acute effects in both groups (subcutaneous fibrosis, telangiectasia, moderate-to-severe oedema, xerostomia, trismus, dysphagia); subcutaneous fibrosis more prevalent with surgery + radiotherapy…
1 study · 35 participants
Very low
Oral disease outcomes, including dental caries estimates · People of all ages and abilities served through primary care and related settings (children, pregnant women, older adults in…
Most studies reported improved oral disease outcomes with integration strategies (8 of 9 studies improved, 1 no change; 9 studies, narrative synthesis; ungraded).
1 finding from 1 review
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
Self-assembling peptide P11-4 did not differ significantly from CPP-ACFP (SMD -0.13, 95% CI -0.68 to 0.42); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Locoregional recurrence · Adults with oral cavity or oropharyngeal cancer
1 finding from 1 review
Locoregional recurrence: reported difference between groups not statistically significant (P=0.355), but no useable data; 32 participants (1 RCT, Iyer 2015).
1 study · 32 participants
Very low
Gingival inflammation-related index · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
Herbal mouthwash reduced some gingival inflammation-related indices, but certainty is very low.
1 finding from 1 review
Intervention not reported
Confidence
1 finding from 1 review
Adverse events associated with treatment · Adults with oral cavity or oropharyngeal cancer with nodal disease (stage N2 or N3)
1 finding from 1 review
Disease-free survival · Adults with oral cavity or oropharyngeal cancer with nodal disease (stage N2 or N3)
1 finding from 1 review
Cariogenic bacteria (Mutans streptococci) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
Herbal mouthwash showed mixed effects on Mutans streptococci, with very low-certainty evidence.
1 finding from 1 review
Development of any (cavitated or non-cavitated) carious lesion · Children younger than 6 years with caries-free primary dentition (no cavitated or non-cavitated lesions at baseline)
Across the sample-based sensitivity analysis, mutans streptococci at baseline were associated with higher odds of developing caries.
1 finding from 1 review
Disease-free survival · Adults with oral cavity cancer
It is very uncertain whether elective radical (comprehensive) neck dissection changes disease-free survival (new disease, progression, and mortality) compared with elective selective neck dissection (very low certainty).
1 finding from 1 review
MMP-20 expression · Human carious dentin
MMP-20 probably reduces in outer compared with inner carious dentin (moderate certainty).
1 finding from 1 review
no estimate extracted
1 study · 5 participants
Moderate
Oral health-related quality of life · Adolescents (10-19 years)
The umbrella review reported a greater negative oral health-related quality-of-life impact for traumatic injuries involving pulp exposure or tooth darkening.
1 finding from 1 review
no estimate extracted
Studies not reported
GRADE not reported
Oral health-related quality of life · Adolescents (10-19 years)
There is no concrete evidence on the impact of skin color/ethnicity on OHRQoL in adolescents (evidence gap; narrative synthesis; no pooled estimate or GRADE rating).
1 finding from 1 review
Pulp necrosis · Vital teeth
The pooled incidence with ≤ 5 years of follow-up was 3.53%.
1 finding from 1 review
Fluoride toothpaste use prevalence (among children with caries) · Children with dental caries (deciduous and/or permanent dentition) in low- and middle-income countries
About 39% of children with caries in LMICs used fluoride toothpaste (pooled prevalence 0.391, 95% CI 0.166 to 0.644; 2 studies; not GRADE-rated).
1 finding from 1 review
Lightness change · Patients with post-orthodontic white spot lesions and permanent dentition
Knosel (2019) reported a statistically significant lightness-change effect.
3 findings from 1 review
Cohen's d 0.71 [0.32, 1.09]
1 study
GRADE not reported
Cohen's d -1.76 [-2.22, -1.30]
1 study
GRADE not reported
Cohen's d 0.40 [0.11, 0.65]
1 study
GRADE not reported
Salivary immunoglobulin A (SIgA) concentration · Children and adolescents (<18 years) living with HIV (CLWH)
Evidence on salivary IgA in CLWH on versus off ART was divergent and inconclusive (very low certainty).
1 finding from 1 review
Restoration failure · Children with carious primary teeth after vital or non-vital pulp therapy
In one RCT, selective caries removal had a 3.44 higher probability of failure than complete caries removal.
1 finding from 1 review