MMP-9 expression/activity · Human ex vivo carious dentin (head/neck radiotherapy)
MMP-9 showed no increase in irradiated vs non-irradiated carious dentin (one study; ungraded).
1 finding from 1 review
MMP-2 location/depth · Human ex vivo carious dentin
No clear direction of MMP-2 presence by lesion depth/location was found; the evidence is very uncertain (very low certainty).
1 finding from 1 review
Root carious lesions prevention · Older adults with root caries (community-dwelling or residential elders)
In elders, sodium fluoride varnish gave a 64% prevented fraction for root caries vs water, lower than SDF (71%) (p<0.01; ungraded).
1 finding from 1 review
MMP-20 location/depth (outer vs inner) · Human ex vivo carious dentin
MMP-20 probably decreases in outer compared with inner carious dentin (moderate certainty).
1 finding from 1 review
Oral health-related quality of life · Adolescents (10-19 years)
Temporomandibular disorder is associated with worse OHRQoL in adolescents (narrative synthesis; no pooled estimate or GRADE rating).
2 findings from 1 review
Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomesCommunity/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
dental caries, malocclusion [9, 26-30], TMD [9], dental trauma (TDI) [32, 34, 35], poor brushing [36], toothache [26], periodontal disease [34] and edentulism [9] negatively affect the quality of life of adolescents.
Studies not reported
GRADE not reported
no estimate extracted
Studies not reported
GRADE not reported
Gingival index (GI) · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)
Herbal mouthwash probably reduces the Gingival Index versus blank control in the short term (WMD -0.20, 95% CI -0.32 to -0.09; moderate certainty).
1 finding from 1 review
Adverse events associated with treatment · Adults with oral cavity cancer (tongue or floor of mouth) and clinically negative neck nodes
1 finding from 1 review
Plaque index (PI) / oral hygiene · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
Chlorhexidine mouthwash reduced Plaque Index versus placebo, but certainty is very low.
1 finding from 1 review
MMP-9 expression/activity · Human ex vivo carious dentin under sealed cavities
MMP-9 shows no difference before vs after cavity sealing; the evidence is very uncertain (very low certainty).
1 finding from 1 review
Inactive (arrested) carious lesions on permanent first molars · Children with dental caries in permanent (first) molars
Six-monthly SDF produced significantly more inactive (arrested) lesions than no treatment in children's permanent molars (0.3 vs 0.1; p<0.05; ungraded).
1 finding from 1 review
Collagen-degrading bacteria · Root caries lesion biofilm
Protein-degrading bacteria capable of degrading collagen were detected in root caries biofilm.
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Oral health-related quality of life · Adolescents (10-19 years)
Higher parental education is associated with better OHRQoL in adolescents (narrative synthesis; no pooled estimate or GRADE rating).
1 finding from 1 review
Total mortality · Adults with oral cavity cancer (tongue or floor of mouth) and clinically negative neck nodes
The review found no eligible studies for this question.
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in permanent teeth undergoing DPC or pulpotomy
MTA achieved higher clinical and radiographic success than calcium hydroxide overall (OR 2.94, 95% CI 1.96-4.49; low certainty), but this unadjusted estimate pools clinically heterogeneous DPC and pulpotomy studies.
1 finding from 1 review
Oral health-related quality of life · Adolescents (10-19 years)
The umbrella review reported that irregular brushing negatively affects oral health-related quality of life.
1 finding from 1 review
no estimate extracted
Studies not reported
GRADE not reported
Salivary caries-associated bacteria (S. mutans and Lactobacilli, subjects with >10^5 CFU/mL) · Orthodontic patients undergoing comprehensive treatment (late mixed or permanent dentition, no active caries)
Both included studies reported higher salivary caries-associated bacteria (S. mutans and Lactobacilli) with fixed appliances than clear aligners; not meta-analyzed (ungraded).
1 finding from 1 review
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
P11-4 plus fluoride varnish did not differ significantly from CPP-ACFP (SMD -0.54, 95% CI -1.15 to 0.08; indirect evidence only); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Disease-free survival · Adults with oral cavity or oropharyngeal cancer
The review found no eligible studies for this question.
1 finding from 1 review
Poor oral health-related quality of life (OHRQoL) · Indians
Results were inconsistent and certainty was very low.
1 finding from 1 review
Total mortality · Adults with oral cavity or oropharyngeal cancer
Sentinel node biopsy (neck dissection only if biopsy positive) showed no clear difference in total mortality compared with elective neck dissection (low certainty).
1 finding from 1 review