Question · asked by 1 review
Irradiated carious dentin vs Non-irradiated carious dentin: MMP-9 expression/activity
- Population
- Human ex vivo carious dentin (head/neck radiotherapy)
- Intervention
- Irradiated carious dentin
- Comparison
- Non-irradiated carious dentin
- Outcome
- MMP-9 expression/activity
MMP-9 showed no increase in irradiated vs non-irradiated carious dentin (one study; ungraded).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Irradiated carious dentin vs Non-irradiated carious dentin MMP-9 expression/activity · Human ex vivo carious dentin (head/neck radiotherapy) · Ex vivo (extracted teeth / clinical carious or biofilm samples) MMP-9 showed no increase in irradiated vs non-irradiated carious dentin (one study; ungraded). Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex… (2023) All outcomes | MMP-9 predominantly positive in non-irradiated vs irradiated carious dentin (single study; ungraded) | 1 study · 36 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo studies. 2023 All outcomes | March 2022 | 18 | Not applicable |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.