Primary caries prevention · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Dental pain or sensitivity · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Enamel surface microhardness · Demineralised / white-spot-lesion enamel (in vitro specimens)
In demineralised enamel, Er:YAG laser irradiation did not significantly change surface microhardness versus untreated control (SMD 0.66, 95% CI -1.12 to 2.44; 2 in vitro studies; ungraded).
1 finding from 1 review
Mother caries (DMFT increment) · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age
Prophylaxis (teeth cleaning) and CHX or iodine-NaF solution… showed no clear difference in mother caries (DMFT increment) compared with placebo; GRADE not reported.
1 finding from 1 review
Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years
Fluoride toothpaste 550 ppm (lower concentration) probably leads to lower fluorosis (percentage prevalence in permanent teeth) compared with fluoride toothpaste 1000 ppm (higher concentration) (moderate certainty).
1 finding from 1 review
Biofilm morphology or biomass · Streptococcus mutans (in vitro cultures and biofilms)
No meta-analysis was conducted; four included studies reported disrupted biofilm structure or reduced biomass with cranberry extract or fractions.
1 finding from 1 review
no estimate extracted
4 studies
GRADE not reported
Intervention not reported
Prenatal vitamin D deficiency prevalence
1 finding from 1 review
Dental caries · Primary school children in Ethiopia
A history of toothache was associated with higher odds of dental caries (OR 2.99, 95% CI 2.679-3.314; ungraded).
1 finding from 1 review
OR 2.99 [2.679, 3.314]
Studies not reported
GRADE not reported
Aesthetics · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Dental caries · Children (<18 years) with vs without dental caries
ApaI(rs7975232) allelic model: C vs A was not significantly associated with dental caries (OR 0.89); ungraded.
1 finding from 1 review
Intervention not reported
Decayed, missing, filled surfaces (DMFS)
The intervention led to higher decayed, missing, filled surfaces (DMFS); GRADE not reported.
1 finding from 1 review
Streptococcus viridans count (CFU/mL) · Children and/or adolescents (<18 years) without background systemic disease
Only one trial (Mishra 2014) reported S. viridans count, showing a higher count with probiotics (MD 0.40 CFU/mL, 95%CI 0.33 to 0.47); not pooled or GRADE-rated.
1 finding from 1 review
Periodontal disease - novel loci (meta-analysis) · Adults from Japanese and European cohorts (present study + GLIDE + UK Biobank + BioBank Japan); periodontal disease cases vs controls
The meta-analysis found no novel loci for periodontal disease; the European SIGLEC5/chr19 locus did not replicate in Japanese populations; ungraded.
1 finding from 1 review
Genome-wide association meta-analysis identifies two novel loci associated with dental caries. 2024 All outcomesLifelong (germline genotype) · Population-based genetic association study (Japanese + European cohorts) · Meta-analysis: present study + GLIDE + UKB + BBJ
Meta-analysis of periodontal disease identified only previously known loci; no novel loci. The chromosome-19 SIGLEC5 locus associated with periodontitis in Europeans was not replicated in Japanese populations (present…
4 studies · 764572 participants
GRADE not reported
Use of alternative/indigenous mouth-cleaning implements · Adult residents of slums and non-slum urban settings of LMICs
Indigenous/alternative cleaning tools and home remedies are widely used, more so in rural/slum groups; ungraded.
1 finding from 1 review
Alternative implements included toothpowder, chewing-stick, neem, charcoal, sand, snuff, salt, miswak, cotton wool and the fingers; native/indigenous tools were used more by rural and slum/disadvantaged residents than…
Studies not reported
GRADE not reported
Enamel demineralization (QLF ΔF) · Human tooth enamel specimens, sound/intact (in vitro)
Er:YAG laser irradiation significantly reduced enamel mineral loss versus untreated control (SMD -2.09, 95% CI -3.29 to -0.88; 4 in vitro studies; ungraded).
1 finding from 1 review
SMD -2.09 [-3.29, -0.88]
4 studies
GRADE not reported
Streptococcus mutans count · Children and adolescents aged 0-18 years with non-syndromic cleft lip and palate (CLP)
No difference in mean Streptococcus mutans presence was reported; GRADE was not reported.
1 finding from 1 review
Intervention not reported
Overall success (composite of clinical and radiographic success)
1 finding from 1 review
Adverse effects · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Caries in primary teeth: dmft (3 years) · Institutionalized orphan children (roughly 3 to 18 years)
Primary-teeth caries experience (dmf) was higher in institutionalized children than parented children but not significantly so (pooled MD 0.64; very low certainty).
1 finding from 1 review
Dental caries prevalence · Brazilian children in primary dentition (BMI classified by CDC 2000 growth charts)
Overweight may make little or no difference to the odds of dental caries in the primary dentition (very low certainty).
1 finding from 1 review