Calcium and phosphate ion release · Human enamel specimens around orthodontic brackets (in vitro)
In vitro, an n-ACP-containing adhesive significantly increased calcium and phosphate ion release up to 42 days in a single study (ungraded).
1 finding from 1 review
Malignant transformation (oral cancer development) · Adults in case-control studies (oral cancer patients vs healthy controls)
The number of missing teeth (per tooth) was not significantly associated with oral cancer (OR 0.96, 95% CI 0.92-1.01); ungraded.
1 finding from 1 review
Intervention not reported
Dental caries prevalence in children
1 finding from 1 review
Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years
It is very uncertain whether started toothbrushing with fluoride toothpaste before 24 months… changes fluorosis (percentage prevalence in permanent teeth) compared with started after 24 months (later start) (very low certainty).
1 finding from 1 review
Salivary S. mutans level · Humans with salivary bacteria measured
Salivary F. nucleatum and Actinobacillus levels were not associated with a clear difference.
1 finding from 1 review
OR 2.39 [1.00, 5.71]
1 study
GRADE not reported
Intervention not reported
Change in prevalence of salivary Streptococcus sobrinus
1 finding from 1 review
Antioxidant capacity · Streptococcus mutans (in vitro cultures and biofilms)
One study reported high antioxidant capacity of grape seed extract (ungraded).
1 finding from 1 review
Early childhood caries (ECC) · Preschool children (<6 years)
Breastfeeding for <18 vs ≥18 months was associated with significantly fewer caries (RR 0.41, 95% CI 0.18-0.92; substantial heterogeneity; ungraded).
2 findings from 1 review
Dental caries prevalence and severity · Persons with disabilities (children and adults with autism, Down syndrome, cerebral palsy, hearing impairment, or multiple disabilities)…
Dental caries prevalence and severity are high among persons with disabilities in Saudi Arabia (60% to over 80%), and the one comparative autism study reported significantly higher caries than controls; synthesized narratively (ungraded).
1 finding from 1 review
Narrative synthesis (no pooled estimate). High dental caries burden among PWDs: caries prevalence 60% to over 80% (abstract). Alkahtani 2019 (hearing-impaired adults, single-arm): caries prevalence 82.2%, treatment…
Studies not reported
GRADE not reported
Bracket (bond) failure · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
Opal Seal showed no difference in bracket failure, with certainty not graded.
1 finding from 1 review
No significant differences were observed in bracket failure rates among different primers, dental arches, bracket types, or sexes.
1 study · 56 participants
GRADE not reported
Primary caries prevention · Children and adults (with or without carious lesions)
It is very uncertain whether silver diamine fluoride (SDF) changes primary caries prevention compared with fluoride varnish (very low certainty).
3 findings from 1 review
MD -0.20 [-0.91, 0.51]
1 study · 100 participants
Very low
OR 0.95 [0.44, 2.05]
1 study · 237 participants
Very low
MD 0.00 [-0.26, 0.26]
1 study · 434 participants
Low
Dental caries in children · Infants and children (aged about 2 to 8 years) whose mothers' vitamin D status was assessed during pregnancy
For prenatal vitamin D measured across gestational weeks 24-38, the OR of dental caries was 1.30 (no CI reported); ungraded.
1 finding from 1 review
Association between prenatal vitamin D deficiency with dental caries in infants and children: a systematic review and… 2024 All outcomesMaternal 25(OH)D measured at gestational weeks 24 to 38 · Observational pregnancy/birth-cohort studies (one cross-sectional), mostly in developed countries (USA, Canada, Japan, Australia, Spain, Netherlands, Poland, New Zealand, Turkey) · Gestational-age subgroup: weeks 24 to 38
OR 1.30 [1.15, 1.45]
4 studies
GRADE not reported
Mixed-type caries (crown and root) · adults
One study reported markedly higher mixed-type caries odds with periodontitis (OR 3.40).
1 finding from 1 review
Caries arrestment at the individual (patient) level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
Pooling two trials, nano-silver fluoride achieved higher individual-level caries arrestment than SDF (OR 0.39 favoring the comparator; ungraded subgroup).
1 finding from 1 review
Intervention not reported
Serum vitamin D (25(OH)D): ECC vs caries-free
The intervention led to lower serum vitamin D (25(OH)D): ECC vs caries-free; GRADE not reported.
1 finding from 1 review
Dental caries · Children (<18 years) with vs without dental caries
FokI(rs2228570) dominant model: AA+AG vs GG was not significantly associated with dental caries (OR 1.07); ungraded.
1 finding from 1 review
Rotation of the mandibular second premolar · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
After mandibular first molar extraction, the second premolar was rotated in about 60% of cases (2 studies; very imprecise; not GRADE-rated).
1 finding from 1 review
Primary caries prevention · Children and adults (with or without carious lesions)
It is very uncertain whether silver diamine fluoride (SDF) changes primary caries prevention compared with placebo or no treatment (very low certainty).
3 findings from 1 review
MD -1.14 [-1.58, -0.70]
1 study · 373 participants
Very low
MD -0.79 [-1.40, -0.17]
3 studies · 439 participants
Moderate
MD -0.69 [-0.97, -0.41]
1 study · 373 participants
Very low
Intervention not reported
Overall success (composite of clinical and radiographic success)
1 finding from 1 review
Secondary prevention of caries · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
3 findings from 1 review
No studies reported data in this dentition type
0 studies
No studies found
MD 0.04 [-0.30, 0.38]
1 study · 309 participants
Very low
No studies reported data in this dentition type
0 studies
No studies found