evidencegaps
Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

3,323 questions · 5,762 findings · 263 reviews · Dental caries

Sort:Best matchNewestHighest certaintyDownload CSV
No studies found 321 · 5.6%GRADE not reported 4,450 · 77.2%Very low 455 · 7.9%Low 297 · 5.2%Moderate 200 · 3.5%High 39 · 0.7%

Ranked among the 5,000 newest matching findings; add words or filters to narrow the search.

Prenatal vitamin D deficiency (low maternal 25(OH)D during pregnancy) vs Adequate prenatal vitamin D (sufficient maternal 25(OH)D)

Dental caries · Children aged 2 to 8 years

The review reported an OR of 1.32 when prenatal vitamin D was measured at 6 to 38 gestational weeks.

2 findings from 1 review

Full pulpotomy vs Partial pulpotomy

Overall success (composite of clinical and radiographic success) · Human permanent teeth with symptomatic irreversible pulpitis due to carious pulp exposure

Full pulpotomy showed a non-significant trend toward higher success than partial pulpotomy in mature teeth with irreversible pulpitis (ungraded).

1 finding from 1 review

Unilateral extraction of the mandibular first permanent molar vs Bilateral extraction of the mandibular first permanent molars

Midline deviation of the mandibular arch · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

One study found midline deviation more likely after unilateral than bilateral extraction (OR 11.6; single study; not GRADE-rated).

1 finding from 1 review

Consumption of xylitol chewing gum by women (mothers) vs Consumption of CHX/xylitol gum by women, or CHX varnish applied to women's dentition

defs index score · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age

It is very uncertain whether consumption of xylitol chewing gum by women (mothers) changes defs index score (categories) compared with consumption of CHX/xylitol gum by women, or CHX varnish applied to… (very low certainty).

2 findings from 1 review

Mineral trioxide aggregate (MTA) vs Calcium hydroxide (CH)

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure

In partial pulpotomy, MTA had significantly higher success than calcium hydroxide (OR 2.81; ungraded).

5 findings from 2 reviews · compare the 2 reviews
Show 2 more findings

Probiotics vs placebo or control

Gingival index (GI) · Children and/or adolescents (<18 years) without background systemic disease

Probiotics probably make little to no difference to the gingival index versus control (MD 0.04, 95%CI -0.18 to 0.27; low certainty).

1 finding from 1 review

Grape seed extract or grape seed flavonoid fractions vs No extract or vehicle control; other antimicrobial agents

Bacterial growth inhibition · Streptococcus mutans (in vitro cultures and biofilms)

No meta-analysis was conducted; five included studies reported inhibition of Streptococcus mutans growth with grape seed extract or fractions.

1 finding from 1 review

Fixed orthodontic treatment with fixed (multibracket) appliances (exposure) vs None (single-group prevalence/incidence estimate)

Association between patient age and number of ICLs · Patients (permanent dentition) during or after fixed orthodontic treatment with fixed (multibracket) appliances

Patient age was not significantly associated with the number of ICLs (ungraded).

1 finding from 1 review

Absence of toothpaste use vs Toothpaste use

Dental caries · Primary school children in Ethiopia

Absence of toothpaste use was not significantly associated with dental caries (OR 1.42, 95% CI -1.278 to 4.109, p=0.3029; ungraded).

1 finding from 1 review

Reduction in previous year's academic score vs No reduction in academic score

Reduction in previous year's academic score · Primary school children in Ethiopia

Dental caries was associated with higher odds of a reduction in the previous year's academic score (OR 5.51, 95% CI 1.952-9.066; ungraded).

1 finding from 1 review

M2 Demirjian stages F-G vs Second molar at Demirjian stage D-E at extraction

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

In the mandible, Demirjian stage F-G vs D-E was not significantly associated with space closure (OR 0.68; not GRADE-rated).

1 finding from 1 review

TT+CC (homozygous) genotypes vs TC (heterozygous) genotype

Dental caries · Children (<18 years) with vs without dental caries

In the Real-time quantitative PCR genotyping subgroup, TaqI(rs731236) over-dominant model: TT+CC vs TC showed a significant association with caries (OR 1.52); ungraded.

8 findings from 1 review
Show 5 more findings

CO2 laser (carbon dioxide) vs No anticaries intervention (untreated enamel)

Enamel surface / cross-sectional microhardness · Human / bovine enamel specimens under cariogenic challenge (in situ / ex vivo)

CO2 laser irradiation changes enamel microhardness versus untreated enamel (MD 49.55, CI 37.74 to 61.37; ungraded, 3 ex-vivo studies, I2=48%); the forest plot shows higher microhardness in laser-treated enamel, although the review text states the opposite.

1 finding from 1 review

Prenatal vitamin D deficiency (low maternal 25(OH)D during pregnancy) vs Adequate prenatal vitamin D (sufficient maternal 25(OH)D)

Dental caries in children · Children aged 6 to 8 years whose mothers' prenatal vitamin D status was assessed

In the single study of children aged 6-8 years, the association was not statistically significant (OR 1.07, 95% CI 0.84-1.30); ungraded.

1 finding from 1 review

Gene sequencing (GS) applied to diagnose/manage oral conditions (predominantly 16S rRNA next-generation sequencing of the oral microbiome; also genome-wide/whole-genome sequencing) vs Negligible ('abysmal') effect of gene sequencing; no separate comparator arm (within-sample event contrast in the forest plots)

Noticeable impact of gene sequencing on diagnosing/managing oral conditions · Human patients (any age) with oral-cavity related disorders (e.g. dental caries, periodontitis, gingivitis, peri-implant mucositis,…

Pooled across 8 clinical trials, gene sequencing had a statistically significant impact on diagnosing/managing oral-cavity disorders (RR 0.50, 95% CI 0.46-0.54); certainty not GRADE-rated.

2 findings from 1 review

Teledentistry (index test): dental caries diagnosis from photographs taken with DSLR or smartphone cameras; store-and-forward vs Visual or clinical examination

Overall diagnostic accuracy (agreement) · Children and adults with primary or permanent dentition undergoing dental caries assessment

Where reported (about 5 studies, Table 2), overall diagnostic accuracy was high (about 93% to 97.6%); no pooled estimate and certainty not graded.

1 finding from 1 review

Oral health education/promotion (oral hygiene advice plus diet and feeding practice advice) combined with clinical treatment for mother's dentition (basic restorative and preventive; 1 trial included CHX varnish application) vs usual care

Child oral health behaviours · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age
1 finding from 1 review

Cranberry extract / juice and proanthocyanidin (flavonoid) fractions vs Untreated or vehicle control (some studies vs positive antimicrobial controls, e.g. chlorhexidine/fluoride)

Biofilm formation (reduction) · Streptococcus mutans (in vitro cultures and biofilms)

Cranberry extract reduces S. mutans biofilm formation in vitro (10 studies; ungraded).

1 finding from 1 review