Attachment change · Adults (> 18 years) with recurrent periodontitis, receiving supportive (maintenance) periodontal care
It is very uncertain whether adjunctive antimicrobial photodynamic therapy (aPDT) applied after… changes change in clinical attachment level (CAL) compared with subgingival instrumentation (SI) alone (hand or power-driven, or… (very low certainty).
2 findings from 1 review
Salivary IL-6 level (pg/mL) · Children and young adults (3-25 years)
Salivary IL-6 levels are significantly higher in children and young adults with active dental caries than in caries-free or mild-caries controls (SMD 11.60 pg/mL, 95% CI 6.27 to 16.94; 11 studies); ungraded.
1 finding from 1 review
Demineralised lesion depth · Human tooth enamel specimens, sound/intact (in vitro)
Er:YAG laser irradiation significantly reduced demineralised lesion depth versus untreated control (SMD -0.55, 95% CI -0.97 to -0.12; 3 in vitro studies, I2=62%; ungraded).
1 finding from 1 review
Adverse events for mother or child · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age
1 finding from 1 review
Early childhood caries (ECC) · Preschool children (<6 years)
Breastfeeding for <12 vs ≥12 months was associated with significantly fewer caries (RR 0.65, 95% CI 0.50-0.86), indicating breastfeeding beyond 12 months increases ECC risk (substantial heterogeneity; ungraded).
2 findings from 1 review
Dental caries · Primary school children in Ethiopia
A significant salivary microbial (Lactobacillus) load was associated with higher odds of dental caries (OR 3.82, 95% CI 3.439-4.192; ungraded).
1 finding from 1 review
OR 3.82 [3.439, 4.192]
Studies not reported
GRADE not reported
Primary caries prevention · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Muscle pain when chewing · People with temporomandibular disorders (TMD)
The review found no eligible studies for this question.
1 finding from 1 review
Positive predictive value for dental caries diagnosis · Children and adults with primary or permanent dentition
Positive predictive values were reported in 10 of the 13 studies that reported sensitivity and specificity; no meta-analysis or GRADE rating was reported.
1 finding from 1 review
no estimate extracted
10 studies
GRADE not reported
Dental caries · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age
The review found no eligible studies for this question.
2 findings from 1 review
Time to alignment · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)
The review found no eligible studies for this question.
1 finding from 1 review
Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
In the mandible, extraction at 11-12 vs 8-10 years showed no significant difference in one analysis (OR 0.82; not GRADE-rated).
2 findings from 1 review
Serum 25-hydroxyvitamin D level · Preschool children ≤6 years, Asia
In Asia, children with S-ECC had lower serum 25(OH)D than caries-free children (WMD -19.25 nmol/l; ungraded).
1 finding from 1 review
ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
It is very uncertain whether facemask (RME) or modified facemask changes ANB compared with other non-surgical orthodontic treatments (mini maxillary… (very low certainty).
1 finding from 1 review
Malignant transformation (oral cancer development) · Adults in case-control studies of oral cancer; people assessed for periodontitis
Periodontitis is associated with roughly a threefold higher odds of oral cancer (pooled OR 2.94, 95% CI 2.13-4.07; low certainty of evidence), though heterogeneity is moderate (I2=52.4%).
1 finding from 1 review
Caries arrest · Children and adults (with or without carious lesions)
It is very uncertain whether silver diamine fluoride (SDF) changes caries arrest compared with placebo or no treatment (very low certainty).
3 findings from 1 review
MD 0.20 [0.00, 0.40]
1 study · 373 participants
Very low
MD 0.24 [0.12, 0.36]
1 study · 158 participants
Very low
MD 0.86 [0.39, 1.33]
2 studies · 841 participants
Low
Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
1 finding from 1 review
Rajendran 2006 (pentoxifylline 14 vs multivitamins 15): reported increased interincisal distance in the pentoxifylline group but no baseline data, so change could not be determined; excluded from meta-analysis.
1 study · 29 participants
GRADE not reported
Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
One study found mandibular Nolla stage 6-7 associated with better space closure (OR 55.1; single study; not GRADE-rated).
1 finding from 1 review
Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
Oxitard (antioxidant) may leads to higher maximal mouth opening (interincisal distance) compared with aloe vera gel (low certainty).
1 finding from 1 review
Streptococcus mutans count · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
TiO2-modified composite showed no S. mutans difference, with certainty not graded.
1 finding from 1 review