Harms: serious adverse effects · Adolescents and adults with malocclusion undergoing orthodontic treatment with fixed or removable appliances
1 finding from 1 review
Rate of orthodontic tooth movement (OTM) during space closure stage (en masse, mm/month) · Adolescents and adults with malocclusion undergoing orthodontic treatment with fixed or removable appliances
Light vibrational forces (LVF) showed no clear difference in rate of orthodontic tooth movement (OTM) during space closure stage… compared with conventional orthodontic appliance treatment (placebo or no adjunct) (low certainty).
1 finding from 1 review
Disease-free survival · Adults with oral cavity cancer (tongue or floor of mouth) and clinically negative neck nodes
1 finding from 1 review
Disease-free survival: Pandey 2018 reported 83% (superselective) vs 91% (selective) at median 36 months, not significant (P=0.69); unable to analyse (variable follow-up); 32 participants (1 RCT).
1 study · 32 participants
Very low
Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in permanent teeth undergoing pulpotomy
For pulpotomy, whether MTA improves success over calcium hydroxide is uncertain (OR 2.36, 95% CI 0.47-11.75; low certainty; CI includes no effect).
1 finding from 1 review
Patient-reported need for analgesics · Adolescents and adults with malocclusion undergoing fixed orthodontic appliance treatment
The review found no eligible studies for this question.
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in permanent teeth undergoing DPC or pulpotomy
Biodentine appeared to perform better than calcium hydroxide for success, but the evidence was not pooled (2 RCTs; ungraded).
1 finding from 1 review
Improvement in occlusion (Peer Assessment Rating (PAR) or other validated scale) · Adolescents and adults with malocclusion undergoing orthodontic treatment with fixed or removable appliances
1 finding from 1 review
Woodhouse 2015 (81 participants, 22 dropouts): PAR reduction intervention median 28.0 (IQR 21.0-38.0), control median 29.0 (IQR 24.0-31.0), placebo median 27.0 (IQR 20.0-35.0); percentage improvement medians 88.9 /…
1 study · 59 participants
GRADE not reported
Patient-reported need for analgesics · Adolescents and adults with malocclusion undergoing orthodontic treatment with fixed or removable appliances
Light vibrational forces (LVF) showed no clear difference in patient-reported need for analgesics during first week of initial… compared with conventional orthodontic appliance treatment (placebo or no adjunct) (low certainty).
1 finding from 1 review
Adverse effects on oral health: Gingival Index (lower arch) · People who had received fixed appliance orthodontic treatment
CAD/CAM nitinol fixed (bonded) retainer showed no clear difference in adverse effects on oral health: Gingival Index (lower arch) compared with conventional/analogue multistrand fixed (bonded) retainer (low certainty).
1 finding from 1 review
Remineralization/arrest of early enamel carious lesions · Patients with early enamel carious lesions on permanent molars
For early enamel lesions, annual SDF+KI was significantly less effective than twice-daily CPP-ACP (54.8% vs 100% arrested; p<0.001; ungraded).
1 finding from 1 review
Orthodontic tooth movement (OTM) during alignment stage · Adolescents and adults with malocclusion undergoing fixed orthodontic appliance treatment
It is very uncertain whether low level laser therapy (LLLT) changes rate of orthodontic tooth movement during alignment stage… compared with conventional orthodontic appliance treatment (very low certainty).
1 finding from 1 review
Intervention not reported
Oral health-related quality of life (impact)
1 finding from 1 review
MMP-2 expression/activity · Human carious dentin from irradiated and non-irradiated subjects
No difference in MMP-2 activity or expression was reported between irradiated and non-irradiated carious dentin.
1 finding from 1 review
Bacterial collagenolytic enzymatic activity · Human ex vivo carious lesions / caries-associated biofilm
Bacterial collagenolytic enzymatic activity in caries biofilm is inconclusive across two small studies (ungraded; GRADE not feasible).
1 finding from 1 review
Results are inconclusive: protein-degrading bacteria isolated from root caries biofilm were capable of degrading collagen (Prevotella, Actinobaculum, Propionibacterium predominant; proportion 7% in root caries)…
2 studies · 9 participants
GRADE not reported
Pulp necrosis · Vital teeth
The pooled incidence with polyether impression material was 4.02%.
1 finding from 1 review
new root-surface carious lesions or restorations · Older adults with root caries in permanent (mature) teeth (mean age 75 years)
SDF had a 71% preventative fraction at 36 months; no pooled estimate or GRADE rating was reported.
1 finding from 1 review
Adverse events associated with treatment · Adults with oral cavity or oropharyngeal cancer
1 finding from 1 review
Total mortality · Adults with oral cavity or oropharyngeal cancer with nodal disease (stage N2 or N3)
PET-CT following chemoradiotherapy (neck dissection only if… showed no clear difference in total mortality compared with planned neck dissection before or after chemoradiotherapy (moderate certainty).
1 finding from 1 review
Gingival inflammation-related index · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
Herbal mouthwash reduced gingival inflammation-related indices versus placebo, but certainty is very low.
1 finding from 1 review
Adverse events associated with treatment · Adults with oral cavity cancer
1 finding from 1 review
Adverse events (BHNCSG 1998): flap necrosis, wound infection, fistula, vascular rupture, haematoma, seroma, chyle fistula; no complications in 45/76 modified radical ND and 54/72 supraomohyoid ND; 2 vs 1 postoperative…
1 study · 148 participants
Low