Question · asked by 1 review
Caries-associated bacterial biofilm vs Sound/control tissue (sound dentin, sound root, or enamel caries): Bacterial collagenolytic enzymatic activity
- Population
- Human ex vivo carious lesions / caries-associated biofilm
- Intervention
- Caries-associated bacterial biofilm
- Comparison
- Sound/control tissue (sound dentin, sound root, or enamel caries)
- Outcome
- Bacterial collagenolytic enzymatic activity
Bacterial collagenolytic enzymatic activity in caries biofilm is inconclusive across two small studies (ungraded; GRADE not feasible).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Caries-associated bacterial biofilm vs Sound/control tissue (sound dentin, sound root, or enamel caries) Bacterial collagenolytic enzymatic activity · Human ex vivo carious lesions / caries-associated biofilm · Ex vivo (extracted teeth / clinical carious or biofilm samples) Bacterial collagenolytic enzymatic activity in caries biofilm is inconclusive across two small studies (ungraded; GRADE not feasible). Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex… (2023) All outcomes | Results are inconclusive: protein-degrading bacteria isolated from root caries biofilm were capable of degrading collagen (Prevotella, Actinobaculum, Propionibacterium predominant; proportion 7% in root caries)… | 2 studies · 9 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo studies. 2023 All outcomes | March 2022 | 18 | Not applicable |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.