Change in height-for-age z score · Preschool children (<6 years)
The review reported an unadjusted negative association between baseline caries and change in height-for-age z score.
1 finding from 1 review
Harms (orthodontically-induced inflammatory root resorption) · Adolescents and adults with malocclusion undergoing orthodontic treatment with fixed or removable appliances
Light vibrational forces (LVF) showed no clear difference in harms and side effects: orthodontically-induced inflammatory root… compared with conventional orthodontic appliance treatment (placebo or no adjunct) (low certainty).
1 finding from 1 review
Oral health-related quality of life · Indian adults and elderly (general, police, teachers, institutionalised)
Evidence on periodontal disease (CPI) and OHRQoL is inconsistent across studies (very low certainty).
2 findings from 1 review
Periodontal disease (CPI) vs none: studies show inconsistency; two studies showed poor QoL (Nagarajappa 2015, Saxena 2018), one no significant association (Shivakumar 2018); 1345 participants, 3 observational studies;…
3 studies · 1345 participants
Very low
SMD -0.18 [-0.53, 0.18]
4 studies · 3064 participants
Very low
Locoregional recurrence · Adults with oral cavity or oropharyngeal cancer
1 finding from 1 review
Oral health-related quality of life · Indians
Continuous analyses (GOHAI, OHIP-14) of gingivitis and OHRQoL were inconsistent and mostly non-significant; ungraded.
1 finding from 1 review
Gingivitis and QoL (continuous): GOHAI - one study found poorer QoL (Appukuttan 2016, P<0.05), one no significant association (Marya 2020, P=0.08); OHIP-14 - no impact (Sreela 2020, P=0.0762). Not pooled.
3 studies
GRADE not reported
Plaque · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
Long-term fluoride mouthwash showed mixed plaque-index effects, with very low-certainty evidence.
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in immature permanent teeth
The effect of MTA versus CH in immature teeth is very uncertain (very low certainty).
1 finding from 1 review
Adverse effects on oral health: bleeding on probing (lower arch) · People who had received fixed appliance orthodontic treatment
The review found no eligible studies for this question.
1 finding from 1 review
Survival of retainers (failure/how many failed) · People who had received fixed appliance orthodontic treatment
It is very uncertain whether hawley removable retainer changes survival of retainers (failure, upper and lower arches) compared with clear plastic removable retainer (very low certainty).
1 finding from 1 review
Patient satisfaction: comfort (VAS, upper and lower arches) · People who had received fixed appliance orthodontic treatment
The review found no eligible studies for this question.
1 finding from 1 review
Periapical pathosis · Vital teeth restored with indirect restorations
Periapical pathosis incidence among follow-up >5-10 years was 3.88% (subgroup analysis; not GRADE-rated).
2 findings from 1 review
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
Resin infiltration significantly improved remineralization versus control (SMD -0.94, 95% CI -1.46 to -0.43), ranking second of seven therapies by SUCRA (88.7%); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Bacterial collagenolytic protease gene expression · Coronal dentin and enamel caries samples
Genes encoding collagenases and other proteases were overrepresented in dentin caries compared with enamel caries.
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Total mortality · Adults with oropharyngeal cancer
Surgery showed no clear difference in total mortality compared with radiotherapy alone (low certainty).
1 finding from 1 review
Patient-reported need for analgesics · Adolescents and adults with malocclusion undergoing fixed orthodontic appliance treatment
The review found no eligible studies for this question.
1 finding from 1 review
Oral health-related quality of life · Adolescents (10-19 years)
Dental caries is associated with worse OHRQoL in adolescents, with greater severity linked to greater impact (narrative synthesis; no pooled estimate or GRADE rating).
1 finding from 1 review
Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomesCommunity/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
The impact of dental caries on OHRQoL was addressed in five systematic reviews [9, 26, 34, 36, 37]. Three articles report that the greater the severity of the carious lesion, the worse the impact on OHRQoL in…
5 studies
GRADE not reported
Recurrence · Adults with oral cavity cancer (tongue or floor of mouth) and clinically negative neck nodes
Elective neck dissection (at time of primary tumour resection) probably leads to lower recurrence compared with therapeutic (delayed) neck dissection (moderate certainty).
1 finding from 1 review
Oral health-related quality of life · Adolescents (10-19 years)
The abstract reports female sex is associated with worse OHRQoL, but the conclusion states the impact of gender was not clarified (narrative synthesis; no pooled estimate or GRADE rating).
1 finding from 1 review
Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomesCommunity/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
Worse oral health status, older age, female sex and worse socioeconomic status were significantly associated with worse OHRQoL. [Conclusion: gender and skin color did not have their level of impact clarified.]
Studies not reported
GRADE not reported
Total number of orthodontic appliance adjustment appointments during treatment · Adolescents and adults with malocclusion undergoing fixed orthodontic appliance treatment
The review found no eligible studies for this question.
1 finding from 1 review
MMP-13 presence/activity · Human ex vivo carious dentin (mostly coronal), natural caries lesions
MMP-13 may be increased in carious dentin compared with sound dentin, but the evidence is very uncertain (very low certainty).
1 finding from 1 review
MMP-13 may be increased in carious dentin when compared to sound dentin, but the evidence is very uncertain (Loreto et al., 2014: more in coronal caries, p<0.05).
1 study · 13 participants
Very low