Caries arrestment at the tooth level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
Pooling two trials, SDF and ART/glass ionomer cement showed no clear difference in tooth-level caries arrestment (OR 1.22, wide CI; ungraded subgroup).
1 finding from 1 review
Aesthetics · Children and adults (with or without carious lesions)
1 finding from 1 review
1 study reported that 45% of parents were satisfied with appearance of their child's teeth; data not reported by study group. 1 study reported that 1 of 34 caregivers in SDF group were "annoyed with teeth appearance",…
2 studies · 248 participants
Very low
Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review
1 study (203 children) reported that black or brown staining on treated lesions was commonly found in both groups, with little or no difference according to whether SDF treatment was given in 3 applications at…
3 studies · 1121 participants
Very low
Calcium ions released in acidic solution · Human tooth enamel specimens, sound/intact (in vitro)
Er:YAG laser irradiation did not significantly change calcium ions released into acidic solution versus untreated control (SMD -0.40, 95% CI -0.96 to 0.15; 6 in vitro studies, I2=80%; ungraded).
1 finding from 1 review
Model development with reported performance measures (per CHARMS) · Individuals of any age at risk of caries increment
No original CAMBRA or CAT model-development studies reporting performance measures according to CHARMS were found (evidence gap); these tools appeared only as validated models within other studies.
1 finding from 1 review
no estimate extracted
0 studies
No studies found
Pulp necrosis · Vital teeth restored with indirect restorations
Pulp necrosis incidence among treated by prosthodontists was 1.87% (subgroup analysis; not GRADE-rated).
15 findings from 1 review
Show 12 more findings
Incidence and influential factors in pulp necrosis and periapical pathosis following indirect restorations: a… 2023 All outcomesFollow-up ≤5 to >10 years · University clinics and dental practices, multiple countries · Temporization >2 weeks
Proportion 4.25 [1.28, 8.85]
2280 participants
GRADE not reported
Incidence and influential factors in pulp necrosis and periapical pathosis following indirect restorations: a… 2023 All outcomes>10 years · University clinics and dental practices, multiple countries · Follow-up >10 years
Proportion 6.74 [2.82, 12.18]
3640 participants
GRADE not reported
Incidence and influential factors in pulp necrosis and periapical pathosis following indirect restorations: a… 2023 All outcomesFollow-up ≤5 to >10 years · University clinics and dental practices, multiple countries · Temporization ≤2 weeks
Proportion 1.47 [0.81, 2.31]
1907 participants
GRADE not reported
Incidence and influential factors in pulp necrosis and periapical pathosis following indirect restorations: a… 2023 All outcomesFollow-up ≤5 to >10 years · University clinics and dental practices, multiple countries · Radiographic pulp-status assessment
Proportion 4.95 [2.43, 8.29]
1853 participants
GRADE not reported
Incidence and influential factors in pulp necrosis and periapical pathosis following indirect restorations: a… 2023 All outcomesFollow-up ≤5 to >10 years · University clinics and dental practices, multiple countries · Polyvinyl siloxane impression material
Proportion 3.17 [1.55, 5.34]
636 participants
GRADE not reported
Incidence and influential factors in pulp necrosis and periapical pathosis following indirect restorations: a… 2023 All outcomesFollow-up ≤5 to >10 years · University clinics and dental practices, multiple countries · Resin permanent cement
Proportion 3.37 [1.90, 5.23]
738 participants
GRADE not reported
Incidence and influential factors in pulp necrosis and periapical pathosis following indirect restorations: a… 2023 All outcomesFollow-up ≤5 to >10 years · University clinics and dental practices, multiple countries · Eugenol-based temporary cement
Proportion 3.34 [1.66, 5.58]
7043 participants
GRADE not reported
Proportion 3.53 [2.10, 5.31]
5532 participants
GRADE not reported
Proportion 5.02 [3.70, 6.52]
37 studies · 11615 participants
Low
Incidence and influential factors in pulp necrosis and periapical pathosis following indirect restorations: a… 2023 All outcomesFollow-up ≤5 to >10 years · University clinics and dental practices, multiple countries · Treated by general practitioners
Proportion 4.44 [2.16, 7.49]
2113 participants
GRADE not reported
Incidence and influential factors in pulp necrosis and periapical pathosis following indirect restorations: a… 2023 All outcomesFollow-up ≤5 to >10 years · University clinics and dental practices, multiple countries · Single-unit restorations
Proportion 5.46 [3.63, 7.64]
20 studies · 5491 participants
GRADE not reported
Incidence and influential factors in pulp necrosis and periapical pathosis following indirect restorations: a… 2023 All outcomesFollow-up ≤5 to >10 years · University clinics and dental practices, multiple countries · Zinc phosphate permanent cement
Proportion 4.92 [3.85, 6.20]
1387 participants
GRADE not reported
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
Resin infiltration did not differ significantly from CPP-ACFP (SMD -0.52, 95% CI -1.16 to 0.12; indirect evidence only); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Access to oral healthcare (referral pathways, documentation processes, operating efficiencies, staffing, visits for oral health issues, uptake of fluoride varnish/other preventive treatment, and visits to an oral health professional) · People of all ages and abilities served through primary care and related settings (children, pregnant women, older adults in…
Most strategies to integrate oral health into primary care were associated with improved access to oral healthcare (19 studies, narrative synthesis; ungraded).
1 finding from 1 review
Strategies to integrate oral health into primary care: a systematic review. 2023 All outcomesPrimary care, community, school, and aged-care/residential/nursing-home settings
Access to oral healthcare was the primary outcome most studied (n=19). Most studies reported results favouring the integration strategy, including improvements in referral pathways, documentation processes, operating…
19 studies
GRADE not reported
Development of any (cavitated or non-cavitated) carious lesion · Children younger than 6 years with caries-free primary dentition (no cavitated or non-cavitated lesions at baseline)
Preschool children with mutans streptococci at baseline probably have about four times higher odds of developing early childhood caries (OR 4.13; moderate certainty).
7 findings from 1 review
Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis. 2023 All outcomes6 months to 3.5 years · Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore · Overall
OR 4.13 [3.33, 5.12]
12 studies · 3010 participants
Moderate
Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis. 2023 All outcomes6 months to 3.5 years · Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore · Sample: plaque
OR 5.16 [2.99, 8.91]
5 studies · 736 participants
GRADE not reported
Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis. 2023 All outcomes6 months to 3.5 years · Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore · Sample: saliva
OR 3.92 [3.20, 4.80]
9 studies · 2577 participants
GRADE not reported
Show 4 more findings
Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis. 2023 All outcomes1 year · Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore · Follow-up: 1 year
OR 4.37 [3.50, 5.45]
4 studies · 2016 participants
GRADE not reported
Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis. 2023 All outcomes2.7 years (31 months median) · Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore · Follow-up: 2.7 years (31 months median)
OR 33.00 [3.18, 342.26]
1 study · 28 participants
GRADE not reported
Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis. 2023 All outcomes2 years · Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore · Follow-up: 2 years
OR 2.53 [1.22, 5.23]
4 studies · 297 participants
GRADE not reported
Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis. 2023 All outcomes6 months to 3.5 years · Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore · Microbiological assessment: quantitative (culture/CFU counting)
OR 3.82 [2.01, 7.26]
6 studies · 732 participants
GRADE not reported
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
P11-4 plus fluoride varnish was significantly better than CPP-ACP (SMD -0.78, 95% CI -1.33 to -0.24; indirect evidence only); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Coronal caries increment · Individuals of all ages
The review reported this model performance without meta-analysis.
108 findings from 1 review
Show 105 more findings
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Gao.2010 [17]; model performance 5
LR− 0.22 [0.19, 0.22]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Gao,2013 [29]; model performance 10
LR− 0.26 [0.18, 0.37]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Hänsel Petersson,2015 [30]; model performance 3
LR− 0.82 [0.77, 0.88]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Beck,1992 [24]; model performance 4
LR− 0.34 [0.28, 0.40]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Birpou,2019 [25]; model performance 2
LR− 0.55 [0.38, 0.82]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Fontana,2011 [16]; model performance 5
LR− 0.36 [0.26, 0.50]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Disney,1992 [15]; model performance 4
LR+ 3.88 [3.19, 4.71]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Pang,2021 [19]; model performance 2
LR− 1.00 [0.85, 1.18]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Pang,2021 [19]; model performance 4
LR+ 1.54 [1.22, 1.94]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Angulo,1995 [13]; model performance 1
LR− 0.94 [0.74, 1.20]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Gao,2013 [29]; model performance 4
LR− 0.48 [0.39, 0.58]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Pang,2021 [19]; model performance 2
LR− 0.79 [0.69, 0.89]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Beck,1992 [24]; model performance 2
LR− 0.44 [0.37, 0.51]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Hänsel Petersson,2015 [30]; model performance 2
LR+ 2.11 [1.82, 2.45]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Pang,2021 [19]; model performance 2
LR+ 1.00 [0.73, 1.38]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Gao.2010 [17]; model performance 4
LR− 0.18 [0.16, 0.22]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Birpou,2019 [25]; model performance 13
LR− 0.66 [0.49, 0.90]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Fontana,2011 [16]; model performance 2
LR− 0.33 [0.24, 0.44]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Birpou,2019 [25]; model performance 3
LR− 0.61 [0.42, 0.88]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Beck,1992 [24]; model performance 5
LR+ 1.64 [1.47, 1.84]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Hänsel Petersson,2015 [30]; model performance 1
LR− 0.32 [0.23, 0.45]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Angulo,1995 [13]; model performance 1
LR+ 1.36 [0.43, 4.31]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Beck,1992 [24]; model performance 3
LR− 0.30 [0.24, 0.36]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Pang,2021 [19]; model performance 3
LR+ 1.86 [1.39, 2.48]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Gao,2013 [29]; model performance 9
LR+ 1.52 [1.37, 1.68]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Beck,1992 [24]; model performance 8
LR− 0.48 [0.41, 0.56]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Fontana,2011 [16]; model performance 6
LR− 0.44 [0.35, 0.56]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Fontana,2011 [16]; model performance 5
LR+ 1.88 [1.34, 2.64]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Gao,2013 [29]; model performance 3
LR− 0.45 [0.37, 0.55]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Fontana,2011 [16]; model performance 9
LR− 0.31 [0.22, 0.43]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Hänsel Petersson,2015 [30]; model performance 3
LR+ 2.72 [2.02, 3.68]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Fontana,2011 [16]; model performance 11
LR− 0.41 [0.30, 0.56]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Christian,2020 [27]; model performance 1
LR+ 1.14 [0.92, 1.41]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Fontana,2011 [16]; model performance 6
LR+ 1.87 [1.49, 2.35]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Birpou,2019 [25]; model performance 7
LR+ 1.58 [1.09, 2.30]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Gao.2010 [17]; model performance 1
LR+ 3.06 [2.73, 3.43]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Pang,2021 [19]; model performance 2
LR+ 1.48 [1.20, 1.82]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Fontana,2011 [16]; model performance 3
LR+ 1.88 [1.65, 2.28]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Gao.2010 [17]; model performance 5
LR+ 4.37 [3.80, 5.04]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Pang,2021 [19]; model performance 4
LR+ 2.71 [2.18, 3.38]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Gao,2013 [29]; model performance 11
LR− 0.14 [0.06, 0.33]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Hänsel Petersson,2010 [31]; model performance 5
LR− 0.50 [0.28, 0.90]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Birpou,2019 [25]; model performance 14
LR− 0.58 [0.42, 0.80]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Beck,1992 [24]; model performance 1
LR− 0.33 [0.28, 0.39]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Hänsel Petersson,2010 [31]; model performance 3
LR− 0.41 [0.29, 0.59]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Holgerson,2009 [32]; model performance 1
LR− 0.61 [0.40, 0.94]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Gao,2013 [29]; model performance 8
LR− 0.31 [0.09, 1.04]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Fontana,2011 [16]; model performance 7
LR− 0.44 [0.35, 0.56]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Hänsel Petersson,2015 [30]; model performance 1
LR+ 1.34 [1.26, 1.43]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Fontana,2011 [16]; model performance 3
LR− 0.33 [0.25, 0.45]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Hänsel Petersson,2010 [31]; model performance 4
LR+ 1.51 [1.30, 1.76]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Hänsel Petersson,2010 [31]; model performance 1
LR− 0.45 [0.33, 0.61]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Pang,2021 [19]; model performance 3
LR− 0.60 [0.49, 0.74]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Pang,2021 [19]; model performance 1
LR− 0.80 [0.71, 0.89]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Gao,2013 [29]; model performance 12
LR− 0.14 [0.08, 0.26]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Fontana,2011 [16]; model performance 8
LR− 0.44 [0.35, 0.56]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Birpou,2019 [25]; model performance 4
LR− 0.58 [0.40, 0.84]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Gao,2013 [29]; model performance 1
LR+ 5.31 [4.01, 7.03]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Beck,1992 [24]; model performance 3
LR+ 1.83 [1.62, 2.06]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Gao.2010 [17]; model performance 2
LR+ 9.04 [7.41, 11.03]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Demers,1992 [14]; model performance 2
LR− 0.40 [0.26, 0.64]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Gao.2010 [17]; model performance 3
LR+ 2.15 [1.96, 2.35]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Gao.2010 [17]; model performance 3
LR− 0.30 [0.26, 0.36]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Disney,1992 [15]; model performance 1
LR+ 3.47 [2.89, 4.16]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Demers,1992 [14]; model performance 1
LR− 0.14 [0.07, 0.28]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Birpou,2019 [25]; model performance 16
LR+ 1.84 [1.24, 2.74]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Gao,2013 [29]; model performance 11
LR+ 1.22 [1.15, 1.30]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Gao,2013 [29]; model performance 6
LR+ 1.03 [1.01, 1.06]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Beck,1992 [24]; model performance 1
LR+ 2.05 [1.82, 2.31]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Holgerson,2009 [32]; model performance 1
LR+ 3.83 [1.39, 10.58]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Beck,1992 [24]; model performance 7
LR+ 1.62 [1.44, 1.82]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Birpou,2019 [25]; model performance 4
LR+ 1.60 [1.15, 2.22]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Fontana,2011 [16]; model performance 8
LR+ 1.87 [1.49, 2.35]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Beck,1992 [24]; model performance 4
LR+ 2.62 [2.27, 3.03]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Demers,1992 [14]; model performance 2
LR+ 1.31 [1.15, 1.50]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Gao,2013 [29]; model performance 10
LR+ 2.26 [1.92, 2.65]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Birpou,2019 [25]; model performance 10
LR− 0.55 [0.38, 0.82]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Disney,1992 [15]; model performance 3
LR− 0.47 [0.40, 0.55]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Dolic,2020 [28]; model performance 2
LR− 0.33 [0.17, 0.62]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Pang,2021 [19]; model performance 3
LR− 0.67 [0.58, 0.77]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Birpou,2019 [25]; model performance 1
LR− 0.59 [0.41, 0.85]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Gao,2013 [29]; model performance 4
LR+ 2.85 [2.24, 3.61]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Fontana,2011 [16]; model performance 10
LR+ 2.05 [1.39, 3.02]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Birpou,2019 [25]; model performance 2
LR+ 1.63 [1.17, 2.26]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Dolic,2020 [28]; model performance 1
LR+ 1.74 [0.93, 3.25]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Beck,1992 [24]; model performance 7
LR− 0.38 [0.31, 0.46]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Birpou,2019 [25]; model performance 5
LR− 0.62 [0.45, 0.86]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Gao,2013 [29]; model performance 7
LR− 0.21 [0.05, 0.92]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Gao,2013 [29]; model performance 12
LR+ 1.66 [1.50, 1.86]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Gao,2013 [29]; model performance 5
LR− 0
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Birpou,2019 [25]; model performance 15
LR− 0.68 [0.50, 0.93]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Birpou,2019 [25]; model performance 8
LR− 0.60 [0.43, 0.83]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Disney,1992 [15]; model performance 1
LR− 0.49 [0.42, 0.58]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Disney,1992 [15]; model performance 2
LR+ 3.69 [3.05, 4.45]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Birpou,2019 [25]; model performance 1
LR+ 1.55 [1.13, 2.13]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Hänsel Petersson,2010 [31]; model performance 5
LR+ 1.13 [1.03, 1.22]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Gao.2010 [17]; model performance 2
LR− 0.11 [0.08, 0.13]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Birpou,2019 [25]; model performance 12
LR− 0.58 [0.40, 0.84]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Sánchez-Pérez,2009 [20]; model performance 1
LR− 0.27 [0.16, 0.46]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Hänsel Petersson,2010 [31]; model performance 1
LR+ 1.83 [1.52, 2.19]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Hänsel Petersson,2015 [30]; model performance 2
LR− 0.55 [0.47, 0.63]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Beck,1992 [24]; model performance 6
LR− 0.55 [0.48, 0.63]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Fontana,2011 [16]; model performance 9
LR+ 2.00 [1.35, 2.95]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Fontana,2011 [16]; model performance 4
LR+ 1.88 [1.34, 2.64]
1 study
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up ≥1 year · Oral health care without geographic restriction · Birpou,2019 [25]; model performance 15
LR+ 1.58 [1.09, 2.30]
1 study
GRADE not reported
Secondary caries · Patients requiring dental restoration; permanent teeth
Over 1 year in permanent teeth, the effect of ACTIVA versus GIC on secondary caries is very uncertain (RR 22.80, 95% CI 0.89-584.17; very low certainty).
1 finding from 1 review
Pulp necrosis · Vital teeth
One study reported a 7.1% incidence in mandibular posterior teeth.
5 findings from 1 review
Proportion 7.1
1 study
GRADE not reported
Proportion 0
1 study
GRADE not reported
Proportion 6.1
1 study
GRADE not reported
Show 2 more findings
Proportion 9.4
1 study
GRADE not reported
Proportion 30.2
1 study
GRADE not reported
Oral health-related quality of life · Indian elderly
One study found edentulism did not affect OHRQoL (dichotomous); ungraded.
3 findings from 1 review
Edentulism and QoL (dichotomous): edentulism did not affect OHRQoL (Shivakumar 2018). Single study, not pooled.
1 study
GRADE not reported
Edentulism and QoL (continuous, GOHAI/WHOQoL): one study reported edentulism negatively influenced QoL (Marina 2019), one found no effect (Appukuttan 2016). Not pooled.
2 studies
GRADE not reported
Edentulism and QoL (continuous, OHIP-14): no significant association between individuals with and without edentulism (Ajai 2020). Single study, not pooled.
1 study
GRADE not reported
Patient satisfaction · People who had received fixed appliance orthodontic treatment
The review found no eligible studies for this question.
1 finding from 1 review
Not measured
0 studies
No studies found
Oral health-related quality of life · Adolescents (10-19 years)
Safe housing and favorable household conditions are associated with better OHRQoL in adolescents (narrative synthesis; no pooled estimate or GRADE rating).
1 finding from 1 review
Plaque · Orthodontic patients undergoing comprehensive treatment (late mixed or permanent dentition, no active caries)
In randomized trials, clear aligners probably reduce plaque accumulation versus fixed appliances, though the subgroup estimate is imprecise and its CI crosses no effect (SMD -1.79, 95% CI -3.63 to 0.04; moderate certainty).
3 findings from 1 review
Intervention not reported
Quality of life
1 finding from 1 review
Cathepsin K (CT-K) presence/activity · Human ex vivo carious dentin (mostly coronal), natural caries lesions
Cathepsin K may be increased in carious dentin (one study), but no certainty rating was assigned (ungraded).
1 finding from 1 review
Higher intensity of immunodetection of CT-K was registered in carious dentin than in sound dentin (Vidal et al., 2014); GRADE was not applied to CT-K.
1 study · 10 participants
GRADE not reported
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
Resin infiltration was significantly better than fluoride varnish (SMD -0.70, 95% CI -1.18 to -0.21); certainty of evidence not assessed (no GRADE).
1 finding from 1 review