Enamel remineralization / carious lesion development · Human enamel specimens around orthodontic brackets (in vitro)
In vitro, an ammonium-based methacrylate-containing adhesive showed significant remineralization/anti-demineralization versus control in a single study (ungraded).
1 finding from 1 review
Pain day 1 · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)
Superelastic NiTi arch wire probably leads to higher pain day 1 compared with thermoelastic NiTi arch wire (moderate certainty).
1 finding from 1 review
Secondary prevention of caries · Children and adults (with or without carious lesions)
It is very uncertain whether SDF (given at a particular frequency, concentration, or duration) changes secondary prevention of caries compared with SDF (given at a different frequency, concentration, or duration) (very low certainty).
1 finding from 1 review
Dental caries prevalence · Brazilian children in primary dentition (BMI classified by CDC 2000 growth charts)
The evidence is very uncertain about the effect of overweight/obesity on caries odds in the primary dentition (very low certainty).
1 finding from 1 review
Aesthetics · Children and adults (with or without carious lesions)
1 finding from 1 review
1 study reported that "only 19 (7%) [older adult participants] raised a complaint about the interventions at the 30-mo [month] examination, and half of them complained of black stain on the treated root surfaces." No…
1 study · 43 participants
Very low
Cell death / cytotoxicity induction · Streptococcus mutans (in vitro cultures and biofilms)
One study reported time-dependent cell-death induction (50% at 10 h) with cranberry extract (ungraded).
1 finding from 1 review
Somatisation · People with temporomandibular disorders (TMD)
Occlusal splint showed no clear difference in somatisation compared with physical therapy (ultrasound, exercise, sensorimotor training,…; GRADE not reported.
1 finding from 1 review
Serum 25-hydroxyvitamin D level · Children aged 6 years or younger (preschool children)
Preschool children with ECC had significantly lower serum 25(OH)D than caries-free children (WMD -13.96 nmol/l; ungraded).
1 finding from 1 review
Reduction in occurrence of oral conditions · Human patients (any age) with oral-cavity related disorders (e.g. dental caries, periodontitis, gingivitis, peri-implant mucositis,…
Pooled across 8 clinical trials, gene sequencing was associated with a statistically significant risk difference for impact on oral-cavity disorders (RD -0.29, 95% CI -0.32 to -0.26); certainty not GRADE-rated.
1 finding from 1 review
Primary caries prevention · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Dental pain or sensitivity · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Enamel surface microhardness · Demineralised / white-spot-lesion enamel (in vitro specimens)
In demineralised enamel, Er:YAG laser irradiation did not significantly change surface microhardness versus untreated control (SMD 0.66, 95% CI -1.12 to 2.44; 2 in vitro studies; ungraded).
1 finding from 1 review
Wits appraisal · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
Hybrid Hyrax (RME) with miniscrews and Class III elastics showed no clear difference in wits appraisal compared with conventional Hyrax (RME) with miniscrews and Class III elastics; GRADE not reported.
1 finding from 1 review
Mother caries (DMFT increment) · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age
Prophylaxis (teeth cleaning) and CHX or iodine-NaF solution… showed no clear difference in mother caries (DMFT increment) compared with placebo; GRADE not reported.
1 finding from 1 review
Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years
Fluoride toothpaste 550 ppm (lower concentration) probably leads to lower fluorosis (percentage prevalence in permanent teeth) compared with fluoride toothpaste 1000 ppm (higher concentration) (moderate certainty).
1 finding from 1 review
Biofilm morphology or biomass · Streptococcus mutans (in vitro cultures and biofilms)
No meta-analysis was conducted; four included studies reported disrupted biofilm structure or reduced biomass with cranberry extract or fractions.
1 finding from 1 review
no estimate extracted
4 studies
GRADE not reported
Intervention not reported
Prenatal vitamin D deficiency prevalence
1 finding from 1 review
Dental caries · Primary school children in Ethiopia
A history of toothache was associated with higher odds of dental caries (OR 2.99, 95% CI 2.679-3.314; ungraded).
1 finding from 1 review
OR 2.99 [2.679, 3.314]
Studies not reported
GRADE not reported
Root resorption · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)
The review found no eligible studies for this question.
1 finding from 1 review
Aesthetics · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review