Experimental adhesive containing ammonium-based methacrylate monomer (MADQUAT) vs Conventional/control orthodontic adhesive (e.g., Transbond XT) or negative control: Enamel remineralization / carious lesion development
- Population
- Human enamel specimens around orthodontic brackets (in vitro)
- Intervention
- Experimental adhesive containing ammonium-based methacrylate monomer (MADQUAT)
- Comparison
- Conventional/control orthodontic adhesive (e.g., Transbond XT) or negative control
- Outcome
- Enamel remineralization / carious lesion development
In vitro, an ammonium-based methacrylate-containing adhesive showed significant remineralization/anti-demineralization versus control in a single study (ungraded).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Experimental adhesive containing ammonium-based methacrylate monomer (MADQUAT) vs Conventional/control orthodontic adhesive (e.g., Transbond XT) or negative control Enamel remineralization / carious lesion development · Human enamel specimens around orthodontic brackets (in vitro) · biofilm cariogenic challenge 5 days, In vitro (laboratory), Overall In vitro, an ammonium-based methacrylate-containing adhesive showed significant remineralization/anti-demineralization versus control in a single study (ungraded). Remineralization and anti-demineralization effect of orthodontic adhesives on enamel surrounding orthodontic… (2024) All outcomes | A study using an orthodontic adhesive containing ammonium-based methacrylate showed significant remineralization power compared with control adhesives [37]. | 1 study | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Remineralization and anti-demineralization effect of orthodontic adhesives on enamel surrounding orthodontic brackets: a systematic review… 2024 All outcomes | 2005 to 2024 (search coverage; exact search date not reported) | 25 | Low / Low |
Studies behind the findings
The primary studies the full-text reviews tie to this outcome. Reviews with headline outcomes only do not list them here.
- Addition of ammonium-based methacrylates to an experimental dental adhesive for bonding metal brackets: Carious lesion development and… · 2017 · included by 1 of these review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.