Pain at 7 days · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement)
It is very uncertain whether postoperative systemic antibiotics… changes pain at 7 days compared with matched placebo, partial or total chemo-mechanical debridement and… (very low certainty).
1 finding from 1 review
Dental caries · Children (<18 years) with vs without dental caries
ApaI(rs7975232) over-dominant model: CC+AA vs CA was not significantly associated with dental caries (OR 0.91); ungraded.
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure
MTA and TotalFill BC had comparable pulpotomy success (ungraded).
1 finding from 1 review
Serum 25-hydroxyvitamin D level · Preschool children ≤6 years, North America
In North America, children with S-ECC had lower serum 25(OH)D than caries-free children (WMD -13.28 nmol/l; ungraded).
1 finding from 1 review
Adverse effects (temporomandibular joint signs and symptoms) · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
1 finding from 1 review
Adverse effects · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
1 finding from 1 review
Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
In the mandible, extraction at age 8-10 (vs after 10) increases odds of space closure (OR 3.32; low certainty).
1 finding from 1 review
Joint pain at rest · People with temporomandibular disorders (TMD)
It is very uncertain whether occlusal splint changes joint pain at rest compared with pharmacological therapy (very low certainty).
1 finding from 1 review
Oral disease prevalence · Adult residents of slums and non-slum urban settings of LMICs
Oral disease prevalence was generally high and worse in slum settings where compared, but no meta-analysis was conducted.
1 finding from 1 review
no estimate extracted
18 studies
GRADE not reported
Quality of life · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
The review found no eligible studies for this question.
1 finding from 1 review
Bacterial growth inhibition · Streptococcus mutans (in vitro cultures and biofilms)
No meta-analysis was conducted; seven included studies reported inhibition of Streptococcus mutans growth with cranberry extract or fractions.
1 finding from 1 review
no estimate extracted
7 studies
GRADE not reported
Dental caries in children · Children (approx. 4-18 years)
Waist circumference was not significantly associated with childhood dental caries (pooled OR 1.08, 95% CI 0.90 to 1.30; I2=47.7%); ungraded.
1 finding from 1 review
Quality of life · Adults (> 18 years) with recurrent periodontitis, receiving supportive (maintenance) periodontal care
The review found no eligible studies for this question.
1 finding from 1 review
Pain day 1 · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)
Superelastic NiTi arch wire showed no clear difference in pain day 1 compared with multistrand stainless steel arch wire (low certainty).
1 finding from 1 review
White spot lesions assessed by laser fluorescence (DIAGNOdent) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)
Two studies found adhesive flash-free brackets did not clinically reduce enamel demineralization or white spot lesions versus conventional brackets, though they reduced pathogenic bacteria (ungraded).
1 finding from 1 review
Dental pain or sensitivity · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Recurrence · People with temporomandibular disorders (TMD)
The review found no eligible studies for this question.
1 finding from 1 review
Adverse effects (tooth staining and other side effects) · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
SDF commonly causes black staining of arrested lesions; only mild, transient adverse events were reported, with no major adverse events (ungraded).
1 finding from 1 review
Negative predictive value · Children and adults with primary or permanent dentition undergoing dental caries assessment
Negative predictive value was reported in 10 studies and ranged widely across studies (about 31% to 99.5%); no pooled estimate and certainty not graded.
1 finding from 1 review
Intervention not reported
Decayed surfaces (DS)
The intervention led to higher decayed surfaces (DS); GRADE not reported.
1 finding from 1 review