Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,323 questions · 5,762 findings · 263 reviews · Dental caries

No studies found 321 · 5.6%GRADE not reported 4,450 · 77.2%Very low 455 · 7.9%Low 297 · 5.2%Moderate 200 · 3.5%High 39 · 0.7%

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Intervention not reported

Initiation of white spot lesions (WSL), visual-tactile assessment

The intervention showed no clear difference in initiation of white spot lesions (WSL), visual-tactile assessment; GRADE not reported.

1 finding from 1 review

Intervention not reported

Initiation of white spot lesions (WSL), visual-tactile assessment

The intervention showed no clear difference in initiation of white spot lesions (WSL), visual-tactile assessment; GRADE not reported.

1 finding from 1 review

Visual classification: ERK (Ekstrand-Ricketts-Kidd system) vs Reference standard (histology, excavation, radiographs/microCT, or tooth separation)

Specificity for detection of enamel caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review

Fluoride-releasing resin-based sealant vs Non-fluoride resin-based sealant

Initiation of white spot lesions (WSL), visual-tactile assessment · Patients of any age (11-40 years) receiving comprehensive/fixed orthodontic treatment with fixed appliances

For resin-based sealants, fluoride release did not significantly change WSL initiation (RR 0.71, wide CI); subgroup not separately GRADE-rated.

1 finding from 1 review

Utilization of dental services assessment (care/restorative index; dental visits) vs None (descriptive prevalence review; subgroup analyses by urban/rural status, country and year)

Dental service utilisation within the past year · Healthy Emirati preschool children in the United Arab Emirates

Utilization of dental services among healthy Emirati preschoolers was very low, with most children never having visited a dentist and very low care indices (narrative synthesis; not GRADE-rated).

1 finding from 1 review

Down syndrome (oral health status) vs Healthy controls

Oral health status (caries, DMFT, calculus, erosion, malocclusion, treatment indices) · Children with Down syndrome in Dubai

One study found children with Down syndrome had similar caries prevalence but higher DMFT, calculus, erosion and malocclusion than controls, with better restorative-care access (narrative synthesis; not GRADE-rated).

1 finding from 1 review

Systemic sclerosis (SSc / scleroderma) vs SSc-free individuals (controls)

DMFT/DMFS index (dental caries experience) · Adults (general and hospital populations assessed in case-control studies)

No statistically significant difference in DMFT index between SSc patients and controls (SMD -0.03, CI includes 0); certainty ungraded.

1 finding from 1 review

COE with light-based detection (e.g. ViziLite Plus, Microlux/DL, VELscope, Identafi 3000) vs Conventional oral examination (COE) alone

Outcome not reported · Apparently healthy adults not reporting symptoms of OPMD or OSCC, attending an organised screening or surveillance programme, or screened…

The review found no eligible studies for this question.

1 finding from 1 review

Concomitant (concurrent) chemoradiotherapy vs Radiotherapy alone

Disease-free survival · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

Concomitant (concurrent) chemoradiotherapy led to lower disease-free survival, concurrent chemoradiotherapy vs radiotherapy… compared with radiotherapy alone (non-resectable tumours); GRADE not reported.

1 finding from 1 review

Early childhood caries (ECC) vs Caries-free controls

Iron deficiency (as defined by trialists) · Preschool children (<6 years)

In a sensitivity analysis excluding one outlier study, ECC remained associated with higher odds of iron deficiency (OR 2.76, 95% CI 2.42 to 3.13); ungraded.

2 findings from 1 review

Optical coherence tomography (OCT) vs Reference standard (histology, excavation, radiographs/microCT, or tooth separation)

Sensitivity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review

Direct composite resin restoration vs Amalgam restoration

Fracture of restorations · People with permanent or adult posterior teeth requiring restoration (parallel-group trials involved children aged 6 to 12 years)

Direct composite resin restoration showed no clear difference in fracture of restorations compared with amalgam restoration (low certainty).

1 finding from 1 review

Clear aligners (Invisalign / thermoformed aligners) vs Fixed appliances

Full-mouth bleeding score (FMBS) · Adolescents/teenagers undergoing orthodontic treatment

A single study reported a lower full-mouth bleeding score with aligners versus fixed appliances in adolescents at 12 months (MD -20.44, 95% CI -22.98 to -17.90; ungraded).

1 finding from 1 review