Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

316 questions · 321 findings · 136 reviews

No studies found 52 · 16.2%GRADE not reported 21 · 6.5%Very low 115 · 35.8%Low 92 · 28.7%Moderate 33 · 10.3%High 8 · 2.5%

Fingolimod 0.5 mg vs placebo

Withdrawals due to adverse events · patients with relapsing‐remitting multiple sclerosis

It is very uncertain whether fingolimod 0.5 mg changes withdrawals due to adverse events compared with placebo (very low certainty).

1 finding from 1 review

Oxycodone MR vs placebo

Withdrawals due to adverse events · adults with neuropathic pain (2 studies in peripheral diabetic neuropathy and 1 study in postherpetic neuralgia)
1 finding from 1 review

Intervention not reported

Withdrawals due to adverse events · adults with fibromyalgia
1 finding from 1 review

Azathioprine or 6‐mercaptopurine vs mesalazine or sulfasalazine

Withdrawals due to adverse events · maintenance of remission in Crohn's disease

It is very uncertain whether azathioprine or 6‐mercaptopurine changes withdrawals due to adverse events compared with mesalazine or sulfasalazine (very low certainty).

1 finding from 1 review

Intervention not reported

Withdrawals due to adverse events

The review found no eligible studies for this question.

1 finding from 1 review

Chondroitin vs placebo

Withdrawals due to adverse events · patients with osteoarthritis

Chondroitin showed no clear difference in withdrawals due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Withdrawals due to adverse events · patients with essential tremor
1 finding from 1 review