Cochrane · systematic review · CD001347
Bisphosphonates for steroid‐induced osteoporosis
Allen, CS, Yeung, JHS, Vandermeer, B, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
MusculoskeletalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 14.3%Very low 0 · 0%Low 3 · 42.9%Moderate 2 · 28.6%High 1 · 14.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Bisphosphonates versus control for adults with GIOP
Population: adults with GIOP
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incident vertebral fractures Radiographic Bisphosphonates vs control | RR 0.57 [0.35, 0.91] | 12 studies · 1343 participants | High |
Incident nonvertebral fractures Radiographic Bisphosphonates vs control | RR 0.79 [0.47, 1.33] | 9 studies · 1245 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Lumbar spine BMD DEXA Bisphosphonates vs control | no estimate extracted | 23 studies · 2042 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Femoral neck BMD DEXA Bisphosphonates vs control | no estimate extracted | 18 studies · 1665 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Serious adverse events Bisphosphonates vs control | RR 0.91 [0.74, 1.12] | 15 studies · 1703 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Withdrawals due to adverse events Bisphosphonates vs control | RR 1.06 [0.77, 1.47] | 15 studies · 1790 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Quality of life Bisphosphonates vs control | no estimate extracted | 0 studies · 0 participants | Ungraded |