Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

13 questions · 13 findings · 8 reviews · Musculoskeletal

No studies found 3 · 23.1%GRADE not reported 0 · 0%Very low 4 · 30.8%Low 4 · 30.8%Moderate 1 · 7.7%High 1 · 7.7%

Sulfasalazine vs placebo

Withdrawals due to adverse events · Patients with ankylosing spondylitis

Sulfasalazine probably leads to higher total number of withdrawals due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Paracetamol vs placebo

Total adverse events: number experiencing 24 weeks · Patients with osteoarthritis of the knee or hip

Paracetamol showed no clear difference in total adverse events: number experiencing 24 weeks compared with placebo (high certainty).

1 finding from 1 review

Diacerein vs placebo

Total number of serious adverse events not measured · patients with osteoarthritis

The review found no eligible studies for this question.

1 finding from 1 review

Muscle relaxant vs control

Total Number of Adverse Events ‐ single dose studies · patients with pain management in rheumatoid arthritis

It is very uncertain whether muscle relaxant changes total Number of Adverse Events ‐ single dose studies compared with control (very low certainty).

1 finding from 1 review

Low‐dose colchicine vs NSAIDs

Number of participants reporting an adverse event · acute gout

Low‐dose colchicine showed no clear difference in total number of participants reporting adverse events compared with NSAIDs (low certainty).

1 finding from 1 review

Muscle relaxant vs control

Total Number of Adverse Events ‐ only studies >24hrs duration · patients with pain management in rheumatoid arthritis

It is very uncertain whether muscle relaxant changes total Number of Adverse Events ‐ only studies >24hrs duration compared with control (very low certainty).

1 finding from 1 review

Intervention not reported

Total number of adverse events (withdrawals due to lack of effect)c · patients with varus medial osteoarthritis of the knee

The intervention showed no clear difference in total number of adverse events (withdrawals due to lack of effect)c (low certainty).

1 finding from 1 review

Preoperative education vs usual care

Total number of serious adverse events (infection, thrombosis, other serious adverse events · patients with knee replacement surgery

Preoperative education showed no clear difference in total number of serious adverse events (infection, thrombosis, other… compared with usual care (low certainty).

1 finding from 1 review

Preoperative education vs usual care

Total number of serious adverse events (infection, thrombosis, other serious adverse events · hip replacement

It is very uncertain whether preoperative education changes total number of serious adverse events (infection, thrombosis, other… compared with usual care (very low certainty).

1 finding from 1 review