evidence/gaps
Cochrane · systematic review · CD008922

Muscle relaxants for pain management in rheumatoid arthritis

Richards, BL, Whittle, SL, Buchbinder, R · Cochrane Database of Systematic Reviews · 2012 · Cochrane Library

MusculoskeletalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 5 · 83.3%Low 1 · 16.7%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Muscle relaxant versus control for pain management in rheumatoid arthritis

Population: patients with pain management in rheumatoid arthritis
6 questions
OutcomeEffectEvidenceStatus / GRADE
Pain ‐ 24hrs (Single dose)
Muscle relaxant vs control
no estimate extracted3 studies · 104 participantsLow
Downgraded: imprecision
Pain ‐ 1‐2 weeks
Muscle relaxant vs control
no estimate extracted3 studies · 104 participantsVery low
Downgraded: risk of bias, imprecision, inconsistency
Withdrawal due to Adverse Events
Muscle relaxant vs control
RR 2.84 [0.31, 26.08]5 studies · 180 participantsVery low
Downgraded: risk of bias, imprecision, inconsistency
Total Number of Adverse Events ‐ only studies >24hrs duration
Muscle relaxant vs control
RR 4.03 [1.08, 15.1]2 studies · 74 participantsVery low
Downgraded: risk of bias, imprecision, inconsistency
Total Number of Adverse Events ‐ single dose studies
Muscle relaxant vs control
RR 1.4 [0.58, 3.41]3 studies · 106 participantsVery low
Downgraded: risk of bias, imprecision
CNS adverse events
Muscle relaxant vs control
RR 5.96 [1.77, 20.08]2 studies · 74 participantsVery low
Downgraded: risk of bias, imprecision, inconsistency