Cochrane · systematic review · CD005117
Diacerein for osteoarthritis
Fidelix, TS, Macedo, CR, Maxwell, LJ, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
MusculoskeletalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
5
No studies
2
Included studies
NR
No studies 2 · 28.6%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 57.1%Moderate 1 · 14.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Diacerein compared with placebo for osteoarthritis
Population: participants with osteoarthritis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain overall visual analogue scale for pain Scale from: 0 to 100 Diacerein vs placebo | no estimate extracted | 1283 participants | Low Downgraded: inconsistency |
Physical function—Lequesne Impairment Index Scale from: 0 to 24 Diacerein vs placebo | no estimate extracted | 1006 participants | Moderate Downgraded: inconsistency |
Radiographic progression—minimum joint space width (decreased over 0.50 mm during the study period) Diacerein vs placebo | RR 0.85 [0.72, 0.99] | 616 participants | Low Downgraded: inconsistency |
Quality of Life not measured Diacerein vs placebo | no estimate extracted | NR | No studies |
Adverse event: diarrhoea Diacerein vs placebo | RR 3.52 [2.42, 5.11] | 1 participants | Low Downgraded: inconsistency |
Withdrawal due to adverse events Diacerein vs placebo | RR 1.29 [0.83, 2.01] | 1476 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Total number of serious adverse events not measured Diacerein vs placebo | no estimate extracted | NR | No studies |