Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,337 questions · 1,354 findings · 566 reviews

No studies found 307 · 22.7%GRADE not reported 81 · 6%Very low 424 · 31.3%Low 310 · 22.9%Moderate 189 · 14%High 43 · 3.2%

Summary of findings: pioglitazone monotherapy vs no intervention

Serious adverse events (N) · people at increased risk for developing type 2 diabetes

Summary of findings: pioglitazone monotherapy showed no clear difference in serious adverse events (N) compared with no intervention (low certainty).

1 finding from 1 review

Intervention not reported

Non‐serious adverse events · vascular dementia
1 finding from 1 review

Intervention not reported

Non‐serious adverse events · participants with β‐thalassaemia

The review found no eligible studies for this question.

1 finding from 1 review

Carvedilol vs beta‐blocker

Non‐serious adverse events · adults with cirrhosis and gastroesophageal varices

It is very uncertain whether carvedilol changes non‐serious adverse events compared with traditional, non‐selective beta‐blockers (very low certainty).

1 finding from 1 review

Intervention not reported

Non‐serious adverse events · people with pressure ulcers

The intervention may leads to higher non‐serious adverse events (low certainty).

1 finding from 1 review