Cochrane · systematic review · CD011510
Carvedilol versus traditional, non‐selective beta‐blockers for adults with cirrhosis and gastroesophageal varices
Zacharias, AP, Jeyaraj, R, Hobolth, L, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Hepato-BiliaryAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 3 · 42.9%Low 4 · 57.1%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Carvedilol compared to traditional, non‐selective beta‐blockers for adults with cirrhosis, portal hypertension and gastroesophageal varices
Population: adults with cirrhosis and gastroesophageal varices
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Carvedilol vs traditional, non‐selective beta‐blockers | RR 0.86 [0.48, 1.53] | 7 studies · 507 participants | Low |
Upper gastrointestinal bleeding Carvedilol vs traditional, non‐selective beta‐blockers | RR 0.77 [0.43, 1.37] | 10 studies · 810 participants | Very low Downgraded: inconsistency |
Serious adverse events Carvedilol vs traditional, non‐selective beta‐blockers | RR 0.97 [0.67, 1.42] | 10 studies · 810 participants | Low |
Non‐serious adverse events Carvedilol vs traditional, non‐selective beta‐blockers | RR 0.55 [0.23, 1.29] | 6 studies · 596 participants | Very low Downgraded: inconsistency |
Hepatic venous pressure gradient at end of treatment (mmHg) Carvedilol vs traditional, non‐selective beta‐blockers | no estimate extracted | 6 studies · 368 participants | Low Downgraded: indirectness |
Reduction in hepatic venous pressure gradient (%) Carvedilol vs traditional, non‐selective beta‐blockers | no estimate extracted | 6 studies · 368 participants | Low Downgraded: indirectness |
Haemodynamic treatment failure Carvedilol vs traditional, non‐selective beta‐blockers | RR 0.76 [0.57, 1.02] | 6 studies · 368 participants | Very low Downgraded: inconsistency |