Cochrane · systematic review · CD000551
Ursodeoxycholic acid for primary biliary cirrhosis
Rudic, JS, Poropat, G, Krstic, MN, et al. · Cochrane Database of Systematic Reviews · 2012 · Cochrane Library
Hepato-BiliaryAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 5 · 71.4%Low 2 · 28.6%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Ursodeoxycholic acid compared with placebo or no intervention for primary biliary cirrhosis
Population: patients with primary biliary cirrhosis.
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality Ursodeoxycholic acid vs placebo or no intervention | RR 0.97 [0.67, 1.42] | 14 studies · 1391 participants | Very low |
All‐cause mortality or liver transplantation Ursodeoxycholic acid vs placebo or no intervention | RR 0.96 [0.74, 1.25] | 15 studies · 1419 participants | Very low Downgraded: imprecision |
Serious adverse events Ursodeoxycholic acid vs placebo or no intervention | RR 0.87 [0.68, 1.12] | 14 studies · 1382 participants | Very low Downgraded: imprecision |
Non‐serious adverse events Ursodeoxycholic acid vs placebo or no intervention | RR 1.46 [0.83, 2.56] | 12 studies · 1277 participants | Very low Downgraded: imprecision |
Pruritus Ursodeoxycholic acid vs placebo or no intervention | RR 0.96 [0.84, 1.09] | 6 studies · 630 participants | Low Downgraded: imprecision |
Serum bilirubin (µmol/l) Ursodeoxycholic acid vs placebo or no intervention | no estimate extracted | 9 studies · 881 participants | Low Downgraded: imprecision, indirectness |
Liver biopsy findings (worsening of histological stage) Ursodeoxycholic acid vs placebo or no intervention | RR 0.62 [0.44, 0.88] | 7 studies · 551 participants | Very low Downgraded: imprecision, inconsistency |