Cochrane · systematic review · CD003756
Intermittent preventive treatment for malaria in children living in areas with seasonal transmission
Meremikwu, MM, Donegan, S, Sinclair, D, et al. · Cochrane Database of Systematic Reviews · 2012 · Cochrane Library
Infectious DiseasesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 4 · 66.7%High 2 · 33.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: Children aged less than 5 years
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical malaria | Rate Ratio 0.26 [0.17, 0.38] | 6 studies · 9321 participants | High |
Severe malaria | Rate Ratio 0.27 [0.1, 0.76] | 2 studies · 5964 participants | High |
Death from any cause | Risk Ratio 0.66 [0.31, 1.39] | 6 studies · 9533 participants | Moderate Downgraded: imprecision |
Moderately severe anaemia | Risk Ratio 0.71 [0.52, 0.98] | 5 studies · 8805 participants | Moderate Downgraded: risk of bias, inconsistency |
Serious drug related adverse events | no estimate extracted | 6 studies · 9533 participants | Moderate Downgraded: imprecision |
Non‐serious adverse events | no estimate extracted | 6 studies · 9533 participants | Moderate Downgraded: risk of bias |