Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

17 questions · 17 findings · 8 reviews · Schizophrenia

No studies found 2 · 11.8%GRADE not reported 7 · 41.2%Very low 3 · 17.6%Low 5 · 29.4%Moderate 0 · 0%High 0 · 0%

SWITCHING ‐ NEW ANTIPSYCHOTIC REGIMEN vs CONTINUATION ON PREVIOUS REGIMEN: 1a. DIFFERENT DEPOT from DEPOT‐medium term (3‐12 months)

Adverse effects: serious · patients with people with schizophrenia who have neuroleptic‐induced weight or metabolic problems
1 finding from 1 review

ASENAPINE vs placebo

Adverse effects: Incidence of serious adverse effects · adults with schizophrenia

It is very uncertain whether ASENAPINE changes adverse effects: Incidence of serious adverse effects compared with PLACEBO (very low certainty).

1 finding from 1 review

HALOPERIDOL vs ARIPIPRAZOLE

Adverse effects: any serious, specific ‐ dystonia during 24 hours · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: any serious, specific ‐ dystonia during 24 hours compared with OTHER ANTIPSYCHOTIC: a. ARIPIPRAZOLE (very low certainty).

1 finding from 1 review

Adjunctive antioxidants for schizophrenia vs placebo

Adverse effects: 1. Serious (any time point) ‐ any serious adverse effect Various methods · patients with schizophrenia

Adjunctive antioxidants for schizophrenia showed no clear difference in adverse effects: 1. Serious (any time point) ‐ any serious adverse… compared with placebo (low certainty).

1 finding from 1 review

CHLORPROMAZINE vs Clotiapine

Adverse effects: incidence of serious adverse effects. Movement disorders ‐ dyskinesia ‐short‐term · patients with schizophrenia

It is very uncertain whether chlorpromazine changes adverse effects: incidence of serious adverse effects. Movement… compared with clotiapine (very low certainty).

1 finding from 1 review

HALOPERIDOL + PROMETHAZINE vs OLANZAPINE

Adverse effects: Specific and serious adverse effect ‐ by 24 hours Central nervous system ‐ excessive sedation · people with psychosis‐induced aggression

HALOPERIDOL + PROMETHAZINE showed no clear difference in adverse effects: Specific and serious adverse effects by 24 hours… compared with ANTIPSYCHOTIC ‐ OLANZAPINE (low certainty).

1 finding from 1 review

HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM

Adverse effects: Specific and serious adverse effect ‐ by 24 hours Central nervous system ‐ excessive sedation · people with psychosis‐induced aggression

HALOPERIDOL + PROMETHAZINE may leads to lower adverse effects: Specific and serious adverse effect ‐ by 24 hours… compared with ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM (low certainty).

1 finding from 1 review

HALOPERIDOL + PROMETHAZINE vs haloperidol

Adverse effects: Specific and serious adverse effects by 24 hours (not death) Central nervous system ‐ seizure · people with psychosis‐induced aggression

HALOPERIDOL + PROMETHAZINE showed no clear difference in adverse effects: Specific and serious adverse effects by 24 hours… compared with ANTIPSYCHOTIC ‐ HALOPERIDOL (low certainty).

1 finding from 1 review

HALOPERIDOL + PROMETHAZINE vs ZIPRASIDONE

Adverse effects: Specific and serious adverse effect ‐ by 24 hours Central nervous system ‐ excessive sedation · people with psychosis‐induced aggression

HALOPERIDOL + PROMETHAZINE showed no clear difference in adverse effects: Specific and serious adverse effect ‐ by 24 hours… compared with ANTIPSYCHOTIC ‐ ZIPRASIDONE (low certainty).

1 finding from 1 review