Cochrane · systematic review · CD005146
Haloperidol plus promethazine for psychosis‐induced aggression
Huf, G, Alexander, J, Gandhi, P, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
SchizophreniaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
41
current version
GRADE rated
22
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 19 · 46.3%Very low 0 · 0%Low 10 · 24.4%Moderate 4 · 9.8%High 8 · 19.5%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
HALOPERIDOL + PROMETHAZINE compared to ANTIPSYCHOTIC ‐ HALOPERIDOL for psychosis‐induced aggression
Population: people with psychosis‐induced aggression
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Tranquil or asleep: Not tranquil or asleep ‐ by 30 minutes HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC ‐ HALOPERIDOL | RR 0.65 [0.49, 0.87] | 1 study · 316 participants | High |
Global state: Needing restraints or seclusion by 12 hours HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC ‐ HALOPERIDOL | RR 0.83 [0.28, 2.44] | 1 study · 60 participants | Low Downgraded: imprecision, indirectness |
Adverse effects: Specific and serious adverse effects by 24 hours (not death) Central nervous system ‐ seizure HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC ‐ HALOPERIDOL | RR 0.95 [0.06, 15.01] | 1 study · 298 participants | Low Downgraded: imprecision, indirectness |
Adverse effect: Specific and serious ‐ Death HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC ‐ HALOPERIDOL | no estimate extracted | 0 studies · 0 participants | Ungraded |
Service outcomes: Not discharged ‐ by 2 weeks HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC ‐ HALOPERIDOL | RR 0.83 [0.64, 1.07] | 1 study · 310 participants | High |
Specific behaviours: Average aggression score ‐ by 12 hours Overt Aggression Scale HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC ‐ HALOPERIDOL | no estimate extracted | 1 study · 60 participants | Low Downgraded: imprecision, indirectness |
Economics: Costs of care HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC ‐ HALOPERIDOL | no estimate extracted | 0 studies · 0 participants | Ungraded |
HALOPERIDOL + PROMETHAZINE compared to ANTIPSYCHOTIC ‐ OLANZAPINE for psychosis‐induced aggression
Population: people with psychosis‐induced aggression
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Tranquil or asleep: Not tranquil or asleep ‐ by 30 mins HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC ‐ OLANZAPINE | RR 0.6 [0.22, 1.61] | 1 study · 300 participants | High |
Global state: Needing restraints or seclusion by 12 hours HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC ‐ OLANZAPINE | RR 5 [0.62, 40.28] | 1 study · 60 participants | Low Downgraded: imprecision, indirectness |
Adverse effects: Specific and serious adverse effects by 24 hours Central nervous system ‐ excessive sedation. HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC ‐ OLANZAPINE | RR 0.67 [0.12, 3.84] | 2 studies · 116 participants | Low Downgraded: imprecision, indirectness |
Adverse effect: Specific ‐ Death HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC ‐ OLANZAPINE | no estimate extracted | 0 studies · 0 participants | Ungraded |
Service outcomes: Not discharged ‐ by 4 hours HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC ‐ OLANZAPINE | RR 0.94 [0.77, 1.16] | 1 study · 300 participants | High |
Specific behaviours: Average aggression score ‐ by 12 hours Overt Aggression Scale HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC ‐ OLANZAPINE | no estimate extracted | 1 study · 60 participants | Low Downgraded: imprecision, indirectness |
Economics: Costs of care7 HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC ‐ OLANZAPINE | no estimate extracted | 0 studies · 0 participants | Ungraded |
HALOPERIDOL + PROMETHAZINE compared to ANTIPSYCHOTIC ‐ ZIPRASIDONE for psychosis‐induced aggression
Population: people with psychosis‐induced aggression
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Tranquil or asleep: Average sedation score ‐ by 30 minutes Ramsay Sedation Scale HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC ‐ ZIPRASIDONE | no estimate extracted | 1 study · 60 participants | Low Downgraded: imprecision, indirectness |
Global state: Needing restraints or seclusion ‐ by 12 hours HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC ‐ ZIPRASIDONE | RR 0.5 [0.19, 1.29] | 1 study · 60 participants | Moderate Downgraded: indirectness |
Adverse effects: Specific and serious adverse effect ‐ by 24 hours Central nervous system ‐ excessive sedation. HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC ‐ ZIPRASIDONE | RR 0.3 [0.06, 1.43] | 2 studies · 111 participants | Low Downgraded: imprecision, indirectness |
Adverse effect: Specific ‐ Death HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC ‐ ZIPRASIDONE | no estimate extracted | 0 studies · 0 participants | Ungraded |
Service outcomes: Not discharged ‐ by 2 weeks HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC ‐ ZIPRASIDONE | no estimate extracted | 0 studies · 0 participants | Ungraded |
Specific behaviours: Average aggression score ‐ by 12 hours Overt Aggression Scale HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC ‐ ZIPRASIDONE | no estimate extracted | 1 study · 60 participants | Moderate Downgraded: imprecision, indirectness |
Economics: Costs of care HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC ‐ ZIPRASIDONE | no estimate extracted | 0 studies · 0 participants | Ungraded |
HALOPERIDOL + PROMETHAZINE compared to ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM for psychosis‐induced aggression
Population: people with psychosis‐induced aggression
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Tranquil or asleep: Average sedation score ‐ by 1 hour Ramsay Sedation Scale HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM | no estimate extracted | 1 study · 60 participants | Low Downgraded: indirectness |
Global state: Needing restraints or seclusion ‐ by 12 hours HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM | RR 0.24 [0.1, 0.55] | 1 study · 60 participants | Ungraded |
Adverse effects: Specific and serious adverse effect ‐ by 24 hours Central nervous system ‐ excessive sedation HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM | RR 0.12 [0.03, 0.49] | 2 studies · 117 participants | Low Downgraded: imprecision, indirectness |
Adverse effect: Specific ‐ Death HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM | no estimate extracted | 0 studies · 0 participants | Ungraded |
Service outcomes: Not discharged ‐ by 2 weeks HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM | no estimate extracted | 0 studies · 0 participants | Ungraded |
Specific behaviours: Average aggression score ‐ by 12 hours Overt Aggression Scale HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM | no estimate extracted | 1 study · 60 participants | Ungraded |
Economics: Costs of care HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM | no estimate extracted | 0 studies · 0 participants | Ungraded |
HALOPERIDOL + PROMETHAZINE compared to BENZODIAZEPINES ‐ LORAZEPAM for psychosis‐induced aggression
Population: people with psychosis‐induced aggression
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Tranquil or asleep: Not tranquil or asleep ‐ by 30 mins HALOPERIDOL + PROMETHAZINE vs BENZODIAZEPINES ‐ LORAZEPAM | RR 0.26 [0.1, 0.68] | 1 study · 200 participants | High |
Global state: Needing restraints or seclusion ‐ by 12 hours HALOPERIDOL + PROMETHAZINE vs BENZODIAZEPINES ‐ LORAZEPAM | RR 0.82 [0.35, 1.89] | 1 study · 200 participants | Moderate Downgraded: indirectness |
Adverse effects: Specific and serious adverse effect ‐ by 24 hours Central nervous system ‐ excessive sedation HALOPERIDOL + PROMETHAZINE vs BENZODIAZEPINES ‐ LORAZEPAM | no estimate extracted | 0 studies · 0 participants | Ungraded |
Adverse effect: Specific ‐ Death HALOPERIDOL + PROMETHAZINE vs BENZODIAZEPINES ‐ LORAZEPAM | no estimate extracted | 0 studies · 0 participants | Ungraded |
Service outcomes: Not discharged ‐ by 4 hours HALOPERIDOL + PROMETHAZINE vs BENZODIAZEPINES ‐ LORAZEPAM | RR 1.13 [0.85, 1.5] | 1 study · 200 participants | High |
Specific behaviours: Average aggression score HALOPERIDOL + PROMETHAZINE vs BENZODIAZEPINES ‐ LORAZEPAM | no estimate extracted | 0 studies · 0 participants | Ungraded |
Economics: Costs of care HALOPERIDOL + PROMETHAZINE vs BENZODIAZEPINES ‐ LORAZEPAM | no estimate extracted | 0 studies · 0 participants | Ungraded |
HALOPERIDOL + PROMETHAZINE compared to BENZODIAZEPINES ‐ MIDAZOLAM for psychosis‐induced aggression
Population: people with psychosis‐induced aggression
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Tranquil or asleep: Not tranquil or asleep HALOPERIDOL + PROMETHAZINE vs BENZODIAZEPINES ‐ MIDAZOLAM | RR 2.9 [1.75, 4.8] | 1 study · 301 participants | High |
Global state: Needing restraints or seclusion‐ by 2 hours HALOPERIDOL + PROMETHAZINE vs BENZODIAZEPINES ‐ MIDAZOLAM | RR 1.22 [0.82, 1.82] | 1 study · 301 participants | Moderate Downgraded: indirectness |
Adverse effect: Specific ‐ Death HALOPERIDOL + PROMETHAZINE vs BENZODIAZEPINES ‐ MIDAZOLAM | no estimate extracted | 0 studies · 0 participants | Ungraded |
Service outcomes: Not discharged ‐ HALOPERIDOL + PROMETHAZINE vs BENZODIAZEPINES ‐ MIDAZOLAM | RR 1.05 [0.84, 1.29] | 1 study · 301 participants | High |
Specific behavioursAggression HALOPERIDOL + PROMETHAZINE vs BENZODIAZEPINES ‐ MIDAZOLAM | no estimate extracted | 4 participants | Ungraded |
Economics: Costs of care HALOPERIDOL + PROMETHAZINE vs BENZODIAZEPINES ‐ MIDAZOLAM | no estimate extracted | 0 studies · 0 participants | Ungraded |