Cochrane · systematic review · CD009830
Haloperidol for long‐term aggression in psychosis
Khushu, A, Powney, MJ · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
SchizophreniaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
4
No studies
3
Included studies
NR
No studies 3 · 42.9%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 14.3%Moderate 0 · 0%High 3 · 42.9%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
HALOPERIDOL versus OTHER ANTIPSYCHOTICS for long‐term aggression in psychosis
Population: people with long‐term aggression in psychosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Specific behaviour: aggression ‐ important decrease in aggression HALOPERIDOL vs OTHER ANTIPSYCHOTICS | no estimate extracted | 83 participants | High |
Specific behaviour: repeated need for tranquillisation HALOPERIDOL vs OTHER ANTIPSYCHOTICS | no estimate extracted | NR | No studies |
Specific behaviours ‐ threat or injury to others/self HALOPERIDOL vs OTHER ANTIPSYCHOTICS | no estimate extracted | 83 participants | High |
Adverse effects ‐ any serious, specific adverse effects HALOPERIDOL vs OTHER ANTIPSYCHOTICS | no estimate extracted | NR | No studies |
Global outcomes ‐ overall improvement HALOPERIDOL vs OTHER ANTIPSYCHOTICS | no estimate extracted | 83 participants | High |
Leaving the study early HALOPERIDOL vs OTHER ANTIPSYCHOTICS | RR 1.37 [0.84, 2.24] | 1 study · 110 participants | Low Downgraded: risk of bias, imprecision, publication bias |
Economic outcomes HALOPERIDOL vs OTHER ANTIPSYCHOTICS | no estimate extracted | NR | No studies |