What do systematic reviews say?

Hydroxyurea vs placebo

• Hydroxyurea (hydroxycarbamide) for sickle cell disease 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 277 participants
  Low

Non‐pharmaceutical interventions vs non‐pharmacological intervention

• Pharmacological and non‐pharmacological strategies for obese women with subfertility 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 11 participants
  Very low

Intervention not reported

The review found no eligible studies for this question.

• Gamma‐aminobutyric acid agonists for antipsychotic‐induced tardive dyskinesia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Noradrenaline reuptake inhibitors vs placebo

• Selective noradrenaline reuptake inhibitors for schizophrenia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 114 participants
  Very low

Shengmai plus usual treatment vs usual treatment alone

• Shengmai (a traditional Chinese herbal medicine) for heart failure 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 60 participants
  Low

Dental caries vs Caries-free controls

In children aged 3-5 years, early childhood caries was significantly associated with poorer OHRQoL (narrative; 3 studies); ungraded.

• Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and Meta-analysis. 2023 All outcomes

  India; community-based and institutional settings across multiple states · Children 3-5 years (ECOHIS/Michigan, continuous)
  Subgroup children 3-5 years (continuous, ECOHIS/Michigan): early childhood caries significantly associated with poorer OHRQoL (Singh N 2020, Ghanghas 2019, Jaggi 2019); not pooled.
  3 studies
  GRADE not reported

Trifocal intraocular lenses vs bifocal intraocular lenses after cataract extraction among participants with presbyopia

The review found no eligible studies for this question.

• Trifocal intraocular lenses versus bifocal intraocular lenses after cataract extraction among participants with… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Physical exercise training vs no exercise

• Exercise training for advanced lung cancer 2019 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 73 participants
  Low

Macrolide+tetracycline vs macrolides

• Head‐to‐head oral prophylactic antibiotic therapy for chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 187 participants
  Very low

tDCS vs sham

• Non‐invasive brain stimulation techniques for chronic pain 2018 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 82 participants
  Low

CHLORPROMAZINE vs OLANZAPINE

• Chlorpromazine versus atypical antipsychotic drugs for schizophrenia 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 61 participants
  Very low

Disability (developmental, intellectual, or sensory) vs Persons without disabilities

Persons with disabilities in Saudi Arabia report poorer overall oral health-related quality of life and greater oral-health impact than those without disabilities, synthesized narratively without a pooled estimate (ungraded).

• Disabilities and Disparities in Oral Health-Related Quality of Life: A Systematic Review and Meta-Analysis in Saudi… 2024 All outcomes

  Cross-sectional · Autism centres, dental hospital, disability centres, hospital, and public schools across Saudi Arabia (Riyadh, Jeddah, Qassim, Abha)
  Narrative synthesis (no pooled estimate). PWDs reported reduced functional, emotional, and social well-being and greater oral-health impact on quality of life. AlJameel 2021 (Down syndrome): 34.9% of children and 46%…
  Studies not reported
  GRADE not reported

CBT vs control

• Psychological interventions for women with non‐metastatic breast cancer 2023 · Cochrane Headline outcomes only
  no estimate extracted
  20 studies · 1747 participants
  Low

Topical vitamin D derivative vs placebo

The review found no eligible studies for this question.

• Interventions for chronic palmoplantar pustulosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Puvatherapy vs placebo or no treatment

The review found no eligible studies for this question.

• Interventions for chronic palmoplantar pustulosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

UVA1 vs narrowband UVB

The review found no eligible studies for this question.

• Interventions for chronic palmoplantar pustulosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Triamcinolone acetonide 0.1% cream with occlusive dressing vs clobetasol cream 0.05% cream

The review found no eligible studies for this question.

• Interventions for chronic palmoplantar pustulosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Etretinate vs placebo or no treatment

The review found no eligible studies for this question.

• Interventions for chronic palmoplantar pustulosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Etretinate with PUVA therapy as co‐intervention vs placebo with PUVA therapy

The review found no eligible studies for this question.

• Interventions for chronic palmoplantar pustulosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Etretinate vs PUVA

The review found no eligible studies for this question.

• Interventions for chronic palmoplantar pustulosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found