What do systematic reviews say?

SMP vs information only

• Self‐management education programmes for osteoarthritis 2014 · Cochrane Headline outcomes only
  no estimate extracted
  648 participants
  Moderate

Bruxism vs No bruxism

Two studies found bruxers have poorer OHRQoL than non-bruxers; narrative, ungraded.

• Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and Meta-analysis. 2023 All outcomes

  India; community-based and institutional settings across multiple states
  Bruxism and QoL (continuous, OHIP-14): bruxers have poorer OHRQoL than non-bruxers (Thetakala 2018, Suguna 2020). Two studies, 284 individuals; not pooled.
  2 studies · 284 participants
  GRADE not reported

Balneotherapy vs no treatment

• Balneotherapy for chronic venous insufficiency 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 153 participants
  Very low

Mepolizumab intravenous (IV) vs placebo

• Anti‐IL‐5 therapies for asthma 2022 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 369 participants
  High

Mepolizumab subcutaneous (SC) vs placebo

• Anti‐IL‐5 therapies for asthma 2022 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 1231 participants
  High

Benralizumab subcutaneous (SC) vs placebo

• Anti‐IL‐5 therapies for asthma 2022 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 2791 participants
  High

Adaptive servo ventilation (ASV) plus best supportive care vs best supportive care alone or inactive control

• Non‐invasive positive pressure ventilation for central sleep apnoea in adults 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low

C1 esterase inhibitor vs placebo or active control

• Interventions for the long‐term prevention of hereditary angioedema attacks 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 36 participants
  Low

Nanofiltered C1 esterase inhibitor vs placebo or active control

• Interventions for the long‐term prevention of hereditary angioedema attacks 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 16 participants
  Very low

Colchicine plus standard care vs placebo or usual care

The review found no eligible studies for this question.

• Colchicine for the treatment of COVID‐19 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Wax (fluid wax), two stage-two step selective pressure final impression vs Polysulfide rubber (elastomer)

The review found no eligible studies for this question.

• Final‐impression techniques and materials for making complete and removable partial dentures 2018 · Cochrane All outcomes
  Not measured
  0 studies
  No studies found

Biofunctional Prosthetic System (BPS): closed-mouth two stage-two step final impression with addition silicone elastomer vs Conventional complete denture technique (CCD): open-mouth two stage-two step conventional technique using elastomer

• Final‐impression techniques and materials for making complete and removable partial dentures 2018 · Cochrane All outcomes

  3 months
  OHIP-EDENT median scores: BPS 34.5; CCD 35.8. No clear difference between groups
  1 study · 10 participants
  Very low

Single-stage alginate impression (simplified method) vs Two stage-two step zinc-oxide eugenol (ZoE) traditional method

It is very uncertain whether single-stage alginate impression (simplified method) changes participant-reported oral health-related quality of life (OHIP-EDENT) compared with two stage-two step zinc-oxide eugenol (ZoE) traditional method (very low certainty).

• Final‐impression techniques and materials for making complete and removable partial dentures 2018 · Cochrane All outcomes

  6 months
  MD 0.5 [-2.67, 3.67]
  1 study · 39 participants
  Very low

Single-stage alginate impression (simplified method) vs Two stage-two step elastomer (silicone, polysulfide, or polyether) conventional method

It is very uncertain whether single-stage alginate impression (simplified method) changes participant-reported oral health-related quality of life (OHIP-EDENT) compared with two stage-two step elastomer (silicone, polysulfide, or polyether)… (very low certainty).

• Final‐impression techniques and materials for making complete and removable partial dentures 2018 · Cochrane All outcomes

  1 month
  MD 0.05 [-2.37, 2.47]
  2 studies · 98 participants
  Very low

Atopiclair vs vehicle

The review found no eligible studies for this question.

• Emollients and moisturisers for eczema 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Urea‐containing moisturisers vs vehicle, placebo or no moisturiser

The review found no eligible studies for this question.

• Emollients and moisturisers for eczema 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Glycerin/glycerol‐containing moisturisers vs vehicle or placebo

The review found no eligible studies for this question.

• Emollients and moisturisers for eczema 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

It is very uncertain whether the intervention changes health‐related quality of life (Change in CRQ Emotional Function) CRQ (very low certainty).

• Exercise training to improve exercise capacity and quality of life in people with non‐malignant dust‐related… 2015 · Cochrane Headline outcomes only
  MD 2.61 [0.74, 4.49]
  2 studies · 39 participants
  Very low

Anti‐IL13 or anti‐IL4 agents vs placebo

• Anti‐interleukin‐13 and anti‐interleukin‐4 agents versus placebo, anti‐interleukin‐5 or anti‐immunoglobulin‐E agents,… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 4960 participants
  High

Intervention vs usual care

• Tailored or adapted interventions for adults with chronic obstructive pulmonary disease and at least one other… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 77 participants
  Low