What do systematic reviews say?

ICD plus optimal medical therapy vs optimal medical therapy alone

• Implantable cardiac defibrillators for people with non‐ischaemic cardiomyopathy 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 561 participants
  Moderate

Erythrocytapheresis vs phlebotomy

The review found no eligible studies for this question.

• Interventions for hereditary haemochromatosis 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Diet, physical activity, and behavioural interventions for the treatment of overweight or obesity in preschool… 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Enhanced recovery protocol vs usual care

• Enhanced recovery protocols for major upper gastrointestinal, liver and pancreatic surgery 2016 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 373 participants
  Very low

Summary of findings table ‐ Systemic therapy vs control

• Systemic therapies for preventing or treating aromatase inhibitor‐induced musculoskeletal symptoms in early breast… 2022 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 208 participants
  Very low

Complex information, support and training interventions vs inactive control (usual care care, attention control, waitlist)

• Remotely delivered information, training and support for informal caregivers of people with dementia 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 311 participants
  Moderate

Complex information, support and training interventions vs information only

• Remotely delivered information, training and support for informal caregivers of people with dementia 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 257 participants
  Low

Anti‐IgE mAb (omalizumab) vs placebo (on top of topical steroids)

• Biologics for chronic rhinosinusitis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 38 participants
  Very low

Exercise vs usual care

• Exercise therapies for preventing or treating aromatase inhibitor‐induced musculoskeletal symptoms in early breast… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 123 participants
  Very low

Intervention not reported

The intervention showed no clear difference in health‐related quality of life: up to 3 months ( (low certainty).

• Glucocorticosteroids for people with alcoholic hepatitis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 377 participants
  Low

Sorafenib vs pazopanib (targeted agent versus targeted agent)

• Targeted therapy for metastatic renal cell carcinoma 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 267 participants
  Low

Cephalomedullary nails vs extramedullary implants

The review found no eligible studies for this question.

• Cephalomedullary nails versus extramedullary implants for extracapsular hip fractures in older adults 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

NSAIDs vs glucocorticoids

The review found no eligible studies for this question.

• Non‐steroidal anti‐inflammatory drugs for acute gout 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

CBT vs other experimental control

• Cognitive behavioural therapy for tinnitus 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 95 participants
  Very low

Pazopanib vs sunitinib (targeted agent versus targeted agent)

• Targeted therapy for metastatic renal cell carcinoma 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 467 participants
  Low

Intervention not reported

It is very uncertain whether the intervention changes general health‐related quality of life [GHQ‐28, IES, (very low certainty).

• Specialist breast care nurses for support of women with breast cancer 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 351 participants
  Very low

Saline irrigation plus pharmacological treatment vs pharmacological treatment alone

• Saline irrigation for allergic rhinitis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Summary of findings table ‐ Metformin + megestrol vs megestrol

The review found no eligible studies for this question.

• Metformin for endometrial hyperplasia 2024 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Metformin vs megestrol

The review found no eligible studies for this question.

• Metformin for endometrial hyperplasia 2024 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Psychological interventions vs usual care

• Psychological interventions for diabetes‐related distress in adults with type 2 diabetes mellitus 2017 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 1932 participants
  Low